SHC1 and INPP5D

  • Number of citations of the paper that reports this interaction (PMID 8643691)
  • 89
  • Data Source:
  • BioGRID (affinity chromatography technology)
  • HPRD (in vivo, in vitro)

SHC1

INPP5D

Gene Name SHC (Src homology 2 domain containing) transforming protein 1 inositol polyphosphate-5-phosphatase, 145kDa
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 134 interactors: ALK AP2A1 AP2A2 APP AXL BCL3 BCR C11orf58 CALCOCO2 CALD1 CBL CBLB CBLC CD22 CD247 CD3E CD81 CDH5 CEACAM1 CRK CRKL CSF1R CSF2RB CSF3R CSK DAG1 DDR1 DDR2 DOK1 DUSP23 EGFR EPHA2 EPOR EPS8 ERBB2 ERBB3 ERBB4 ESR1 FAM118B FCGR2A FCGR3A FGFR1 FLT1 FLT4 FYN GAB1 GAB2 GEMIN7 GH1 GHR GRAP GRAP2 GRB2 GRB7 HMOX2 IGF1R IL2 IL2RB IL2RG IL4R IL6ST ILK INPP5D INPPL1 INSR IRS1 IRS2 ITGB3 ITGB4 JAK2 KDR KRT18 LCK LCP2 LRP1 LTK LYN MAP4K1 MAPK1 MAPK14 MAPK6 MAPK8 MAPKAPK2 MET MME MPL MRPL44 MST1R NGFR NPM1 NTRK1 NTRK2 NTRK3 NUDT21 OSGEP PAG1 PAK1 PDGFRB PIK3C2B PIK3R1 PIK3R2 PLCG1 PLCG2 PLSCR1 PPAP2B PPP2R5A PRKCA PRKCD PRKRA PTK2 PTK2B PTPN11 PTPN12 PTPN2 PTPN6 RAPGEF1 RASA1 RET SH2B2 SHCBP1 SOS1 SOS2 SP1 SRC STAT5A STAT5B SUV39H2 SYK TEC TEK TPR VAV1 VAV3 ZAP70 40 interactors: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NL PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 XIAP ZDHHC17
Entrez ID 6464 3635
HPRD ID 02780 09033
Ensembl ID ENSG00000160691 ENSG00000168918
Uniprot IDs P29353 Q92835
PDB IDs 1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 1WCP 2L1C 2YSX
Enriched GO Terms of Interacting Partners?
Tagcloud ?
adaptors  assumptions  combinatorial  complexity  cooperativity  dealt  demodification  descriptions  disallow  hinders  hoc  lumped  modelling  obstacle  ode  odes  ordinary  pharmacology  phosphatases  plcgamma1  rasa1  reasonably  relaxed  retaining  shp2  simulate  subdomains  tyrosines  unphosphorylated 
cytoskeleton  dataset  deposited  dysregulation  exerts  expand  heterodimeric  http  identifier  inositol  mapkapk2  nad  nadk  nonreceptor  org  pertaining  phosphatases  phosphoproteome  phosphoproteomic  polyphosphate  proteomecentral  proteomexchange  ptpn12  pxd000984  reorganization  ripk1  silac  threonine  tnfrsf 
Tagcloud (Difference) ?
adaptors  assumptions  combinatorial  complexity  cooperativity  dealt  demodification  descriptions  disallow  hinders  hoc  lumped  modelling  obstacle  ode  odes  ordinary  pharmacology  plcgamma1  rasa1  reasonably  relaxed  retaining  shp2  simulate  subdomains  tyrosines  unphosphorylated 
cytoskeleton  dataset  deposited  dysregulation  exerts  expand  heterodimeric  http  identifier  inositol  mapkapk2  nad  nadk  nonreceptor  org  pertaining  phosphoproteome  phosphoproteomic  polyphosphate  proteomecentral  proteomexchange  ptpn12  pxd000984  reorganization  ripk1  silac  threonine  tnfrsf 
Tagcloud (Intersection) ?
phosphatases