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SHC1 and KRT18
Number of citations of the paper that reports this interaction (PubMedID
12577067
)
0
Data Source:
HPRD
(in vitro)
SHC1
KRT18
Description
SHC adaptor protein 1
keratin 18
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Cytosol
Plasma Membrane
Focal Adhesion
Anchoring Junction
Shc-EGFR Complex
Nucleus
Nucleolus
Cytoplasm
Microtubule Organizing Center
Cytosol
Cytoskeleton
Intermediate Filament
Adherens Junction
Nuclear Matrix
Centriolar Satellite
Keratin Filament
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Cell Periphery
Molecular Function
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Epidermal Growth Factor Receptor Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Phospholipid Binding
Receptor Tyrosine Kinase Binding
Ephrin Receptor Binding
Epidermal Growth Factor Binding
RNA Binding
Structural Molecule Activity
Protein Binding
Scaffold Protein Binding
Cadherin Binding Involved In Cell-cell Adhesion
Biological Process
Angiogenesis
Epidermal Growth Factor Receptor Signaling Pathway
Heart Development
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Negative Regulation Of Angiogenesis
Actin Cytoskeleton Organization
Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Defense Response To Bacterium
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Proliferation In Bone Marrow
Regulation Of Superoxide Metabolic Process
Cell-cell Adhesion
Anatomical Structure Morphogenesis
Tumor Necrosis Factor-mediated Signaling Pathway
Golgi To Plasma Membrane Protein Transport
Negative Regulation Of Apoptotic Process
Intermediate Filament Cytoskeleton Organization
Extrinsic Apoptotic Signaling Pathway
Hepatocyte Apoptotic Process
Cell-cell Adhesion
Pathways
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signalling to RAS
Signalling to RAS
SHC1 events in EGFR signaling
Tie2 Signaling
Integrin signaling
XBP1(S) activates chaperone genes
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor signalling cascade
RET signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-2 signaling
Erythropoietin activates RAS
Erythropoietin activates RAS
Interleukin receptor SHC signaling
Constitutive Signaling by Overexpressed ERBB2
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Signaling by CSF1 (M-CSF) in myeloid cells
Keratinization
Formation of the cornified envelope
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
Diseases
GWAS
Bipolar disorder (
31043756
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Eosinophil count (
29403010
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
27569725
)
Prostate cancer (
23535732
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Diffusing capacity of carbon monoxide (
30694715
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Interacting Genes
144 interacting genes:
ALK
AP2A1
AP2A2
APP
AR
AXL
BCL3
BCR
BUB1
C11orf58
CALCOCO2
CALD1
CBL
CBLB
CBLC
CD22
CD247
CD3E
CD81
CDH5
CEACAM1
CFTR
CRK
CRKL
CSF1R
CSF2RB
CSF3R
CSK
DAG1
DDR1
DDR2
DOK1
DUSP23
EGFR
EPHA2
EPOR
EPS8
ERBB2
ERBB3
ERBB4
ESR1
FAM118B
FBXW7
FCGR2A
FCGR3A
FGFR1
FGFR2
FLT1
FLT4
FYN
GAB1
GAB2
GEMIN7
GH1
GHR
GRAP
GRAP2
GRB2
GRB7
HMOX2
IGF1R
IL2
IL2RB
IL2RG
IL4R
IL6ST
ILK
INPP5D
INPPL1
INSR
IRS1
IRS2
ITGB3
ITGB4
JAK2
KDR
KIT
KRT18
LCK
LCP2
LRP1
LTK
LYN
MAP4K1
MAPK1
MAPK14
MAPK6
MAPK8
MAPKAPK2
MET
MME
MPL
MRPL44
MST1R
NGFR
NPM1
NTRK1
NTRK2
NTRK3
NUDT21
OSGEP
PAG1
PAK1
PDGFRB
PIK3C2B
PIK3R1
PIK3R2
PLCG1
PLCG2
PLPP3
PLSCR1
PPP2R5A
PRKCA
PRKCD
PRKRA
PTK2
PTK2B
PTPN11
PTPN12
PTPN2
PTPN6
RAPGEF1
RASA1
RB1
RET
SH2B2
SHCBP1
SMAD4
SOS1
SOS2
SP1
SRC
STAT5A
STAT5B
SUV39H2
SYK
TEC
TEK
TPR
TRIM15
UBASH3B
VAV1
VAV3
ZAP70
94 interacting genes:
AIRIM
BBS1
BBS2
BBS4
BBS7
CAMK2A
CASP3
CASP6
CASP7
CASP8
CBL
CCDC146
CCDC85B
CCHCR1
CCNI
CDC5L
CDK1
COL17A1
DEDD
DNAJB6
EFHC1
EGFR
EP300
ESR1
EXOC8
FRAT1
FXR1
FXR2
GIT2
GOLGA2
GRN
HAUS1
HGS
HRAS
HSPA1A
HSPA4
HSPA5
HSPB1
IKBKG
KIFC3
KPNA2
KRT15
KRT4
KRT5
KRT6A
KRT6C
KRT71
KRT72
KRT8
KRT81
LDOC1
LINC01554
MAPK14
NEFL
NME7
ORC5
PDE4B
PDE4DIP
PIAS4
PKD1
PKP2
PKP3
PNN
POT1
PRKCA
PRKCE
PSTPIP2
RAF1
RCOR3
RHPN2
RPS6KA3
SERPINE1
SHC1
SMARCD1
SVIL
SYCE1
TCHP
TEKT4
TNFRSF1B
TRADD
TSG101
TUBG1
TUBGCP4
TXN2
TXNDC11
UPF2
USH2A
WBP2
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAZ
Entrez ID
6464
3875
HPRD ID
02780
01020
Ensembl ID
ENSG00000160691
ENSG00000111057
Uniprot IDs
P29353
P05783
PDB IDs
1MIL
1N3H
1OY2
1QG1
1SHC
1TCE
2L1C
4JMH
4XWX
5CZI
6DM4
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Transmembrane Receptor Protein Tyrosine Kinase Activity
Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Kinase Activity
Receptor Complex
Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Kinase Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Plasma Membrane
Positive Regulation Of MAPK Cascade
Protein Phosphorylation
Positive Regulation Of Multicellular Organismal Process
Regulation Of Immune System Process
Phosphorylation
Phosphotyrosine Residue Binding
Intracellular Signal Transduction
Regulation Of Developmental Process
Protein Autophosphorylation
Immune System Process
Regulation Of Immune Response
Regulation Of Programmed Cell Death
Regulation Of Cell Adhesion
Intracellular Signaling Cassette
Response To Growth Factor
Cell Activation
Cytokine-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Cell Migration
Regulation Of Apoptotic Process
Positive Regulation Of Cell Migration
Regulation Of Cell Activation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Developmental Process
Positive Regulation Of Cell Motility
Cytosol
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Intermediate Filament Organization
Cytoplasm
Organelle Organization
Cytoskeleton Organization
Intermediate Filament
Keratin Filament
Structural Constituent Of Skin Epidermis
Cytoskeleton
Establishment Of Protein Localization
Nucleus
Developmental Process
Supramolecular Fiber Organization
BBSome
Regulation Of Apoptotic Process
Intracellular Protein Localization
Protein Domain Specific Binding
Regulation Of Programmed Cell Death
Cellular Component Assembly
Centrosome
Regulation Of Protein Metabolic Process
Keratinization
Establishment Of Localization In Cell
Reproductive Process
Response To Lipid
Enzyme Binding
Apoptotic Process
Protein Binding
Regulation Of Cellular Component Organization
Programmed Cell Death
Cell Death
Cellular Response To Staurosporine
Ciliary Basal Body
Cellular Localization
Negative Regulation Of Programmed Cell Death
Apoptotic Signaling Pathway
Regulation Of Protein Localization
Intracellular Signal Transduction
Hippocampus Development
Regulation Of Microtubule Nucleation
Phosphoserine Residue Binding
Focal Adhesion
Pyroptotic Inflammatory Response
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Apoptotic Process
Regulation Of Macromolecule Biosynthetic Process
Death-inducing Signaling Complex
Desmosome Assembly
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Tagcloud (Difference)
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Tagcloud (Intersection)
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