SHC1 and GH1

Number of citations of the paper that reports this interaction (PubMedID 7535773)
0

Data Source:
BioGRID (enzymatic study)

		SHC1	GH1
Description		SHC adaptor protein 1	growth hormone 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Focal Adhesion Anchoring Junction Shc-EGFR Complex	Extracellular Region Extracellular Space Cytoplasm Endomembrane System Extracellular Matrix Endosome Lumen Vesicle Growth Hormone Receptor Complex
	Molecular Function	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phospholipid Binding Receptor Tyrosine Kinase Binding Ephrin Receptor Binding Epidermal Growth Factor Binding	Cytokine Activity Growth Hormone Receptor Binding Prolactin Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Metal Ion Binding Growth Hormone Activity
	Biological Process	Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Heart Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Cell Population Proliferation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Proliferation In Bone Marrow Regulation Of Superoxide Metabolic Process Cell-cell Adhesion	Positive Regulation Of Receptor Internalization Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of D-glucose Transmembrane Transport Cytokine-mediated Signaling Pathway Response To Nutrient Levels Response To Estradiol Positive Regulation Of Multicellular Organism Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Animal Organ Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Bone Maturation Cell Surface Receptor Signaling Pathway Via STAT
Pathways		Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signalling to RAS Signalling to RAS SHC1 events in EGFR signaling Tie2 Signaling Integrin signaling XBP1(S) activates chaperone genes Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade Insulin receptor signalling cascade RET signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Erythropoietin activates RAS Erythropoietin activates RAS Interleukin receptor SHC signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells	Prolactin receptor signaling Prolactin receptor signaling Synthesis, secretion, and deacylation of Ghrelin Growth hormone receptor signaling Growth hormone receptor signaling
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Eosinophil count ( 29403010) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Appendicular lean mass ( 33097823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		144 interacting genes: ALK AP2A1 AP2A2 APP AR AXL BCL3 BCR BUB1 C11orf58 CALCOCO2 CALD1 CBL CBLB CBLC CD22 CD247 CD3E CD81 CDH5 CEACAM1 CFTR CRK CRKL CSF1R CSF2RB CSF3R CSK DAG1 DDR1 DDR2 DOK1 DUSP23 EGFR EPHA2 EPOR EPS8 ERBB2 ERBB3 ERBB4 ESR1 FAM118B FBXW7 FCGR2A FCGR3A FGFR1 FGFR2 FLT1 FLT4 FYN GAB1 GAB2 GEMIN7 GH1 GHR GRAP GRAP2 GRB2 GRB7 HMOX2 IGF1R IL2 IL2RB IL2RG IL4R IL6ST ILK INPP5D INPPL1 INSR IRS1 IRS2 ITGB3 ITGB4 JAK2 KDR KIT KRT18 LCK LCP2 LRP1 LTK LYN MAP4K1 MAPK1 MAPK14 MAPK6 MAPK8 MAPKAPK2 MET MME MPL MRPL44 MST1R NGFR NPM1 NTRK1 NTRK2 NTRK3 NUDT21 OSGEP PAG1 PAK1 PDGFRB PIK3C2B PIK3R1 PIK3R2 PLCG1 PLCG2 PLPP3 PLSCR1 PPP2R5A PRKCA PRKCD PRKRA PTK2 PTK2B PTPN11 PTPN12 PTPN2 PTPN6 RAPGEF1 RASA1 RB1 RET SH2B2 SHCBP1 SMAD4 SOS1 SOS2 SP1 SRC STAT5A STAT5B SUV39H2 SYK TEC TEK TPR TRIM15 UBASH3B VAV1 VAV3 ZAP70	7 interacting genes: GHR PRLR PSMD9 S100A6 S100P SHC1 TREM2
Entrez ID		6464	2688
HPRD ID		02780	00751
Ensembl ID		ENSG00000160691	ENSG00000259384
Uniprot IDs		P29353	B1A4G6 B1A4G7 P01241
PDB IDs		1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 2L1C 4JMH 4XWX 5CZI 6DM4	1A22 1AXI 1BP3 1HGU 1HUW 1HWG 1HWH 1KF9 3HHR 6QIO
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Receptor Complex Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Plasma Membrane Positive Regulation Of MAPK Cascade Protein Phosphorylation Positive Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Phosphorylation Phosphotyrosine Residue Binding Intracellular Signal Transduction Regulation Of Developmental Process Protein Autophosphorylation Immune System Process Regulation Of Immune Response Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Intracellular Signaling Cassette Response To Growth Factor Cell Activation Cytokine-mediated Signaling Pathway Positive Regulation Of Immune System Process Cell Migration Regulation Of Apoptotic Process Positive Regulation Of Cell Migration Regulation Of Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Cell Motility	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Lipid Binding Peptide Hormone Binding Extracellular Region Regulation Of Cell Population Proliferation Protein Tyrosine Kinase Binding Insulin-like Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cytokine Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine Receptor Activity Response To Bacterium Calcium-dependent Protein Binding Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Positive Regulation Of Complement Activation, Classical Pathway Detection Of Lipoteichoic Acid Excitatory Synapse Pruning Positive Regulation Of Synapse Pruning Regulation Of Toll-like Receptor 6 Signaling Pathway Growth Hormone Receptor Activity Positive Regulation Of MAPK Cascade Prolactin Receptor Activity Shc-EGFR Complex Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Detection Of Peptidoglycan Regulation Of Engulfment Of Apoptotic Cell Growth Hormone Receptor Complex Response To Cycloheximide Regulation Of MAPK Cascade Protein Homodimerization Activity Plasma Membrane Hormone-mediated Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Prolactin Signaling Pathway Activation Of Janus Kinase Activity Proteasome Regulatory Particle Assembly Positive Regulation Of Protein Secretion Positive Regulation Of Cell Proliferation In Bone Marrow Phospholipid Binding Epidermal Growth Factor Binding Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of ERK1 And ERK2 Cascade Neurotrophin TRKA Receptor Binding Positive Regulation Of Macrophage Fusion Sulfatide Binding Negative Regulation Of Astrocyte Activation CXCL12-activated CXCR4 Signaling Pathway
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