SHC1 and PIK3R1

Number of citations of the paper that reports this interaction (PMID 8662998)
25

Data Source:
HPRD (in vivo, in vitro)

		SHC1	PIK3R1
Gene Name		SHC (Src homology 2 domain containing) transforming protein 1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrial Matrix Cytosol Plasma Membrane Shc-EGFR Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phospholipid Binding Protein Kinase Binding Ephrin Receptor Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Transcription Factor Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulator Activity ErbB-3 Class Receptor Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Angiogenesis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Ras Protein Signal Transduction Heart Development Blood Coagulation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Single Organismal Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Platelet Activation Endoplasmic Reticulum Unfolded Protein Response Actin Cytoskeleton Reorganization Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of DNA Replication Neurotrophin TRK Receptor Signaling Pathway Leukocyte Migration	Cellular Glucose Homeostasis Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Phosphatidylinositol 3-kinase Signaling Viral Process Platelet Activation B Cell Differentiation Positive Regulation Of Cell Migration T Cell Costimulation Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Positive Regulation Of RNA Splicing Cellular Response To UV Response To Endoplasmic Reticulum Stress Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Small Molecule Metabolic Process Innate Immune Response Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glucose Import Phosphatidylinositol Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Protein Stabilization T Cell Receptor Signaling Pathway Leukocyte Migration NFAT Protein Import Into Nucleus Growth Hormone Receptor Signaling Pathway Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Pathways		Signaling by GPCR Signaling by EGFRvIII in Cancer Platelet Aggregation (Plug Formation) SHC1 events in ERBB2 signaling IRE1alpha activates chaperones Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling SHC-mediated signalling G-protein beta:gamma signalling SHC-related events triggered by IGF1R Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins GPCR downstream signaling SHC1 events in ERBB4 signaling Signalling to RAS Signaling by EGFR in Cancer Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Signalling to ERKs IGF1R signaling cascade XBP1(S) activates chaperone genes G beta:gamma signalling through PI3Kgamma Unfolded Protein Response (UPR) Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SHC-mediated signalling Integrin alphaIIb beta3 signaling Signaling by Ligand-Responsive EGFR Variants in Cancer Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane SHC-related events Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall SHC1 events in EGFR signaling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Interleukin receptor SHC signaling GPVI-mediated activation cascade Constitutive Signaling by EGFRvIII SHC activation	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Signaling by FGFR1 mutants Interleukin-7 signaling Role of phospholipids in phagocytosis Phospholipid metabolism Fcgamma receptor (FCGR) dependent phagocytosis PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling G alpha (q) signalling events Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Signaling by Interleukins TCR signaling Signaling by VEGF GP1b-IX-V activation signalling Downstream signal transduction Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Downstream TCR signaling Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway Synthesis of PIPs at the plasma membrane IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events Antigen activates B Cell Receptor (BCR) leading to generation of second messengers PI Metabolism Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Interleukin receptor SHC signaling Signaling by FGFR1 fusion mutants Constitutive Signaling by EGFRvIII PI3K Cascade
Drugs			Isoproterenol (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
Diseases
GWAS		Prostate cancer ( 23535732)	Alzheimer's disease biomarkers ( 23419831) Menarche (age at onset) ( 23599027)
Protein-Protein Interactions		134 interactors: ALK AP2A1 AP2A2 APP AXL BCL3 BCR C11orf58 CALCOCO2 CALD1 CBL CBLB CBLC CD22 CD247 CD3E CD81 CDH5 CEACAM1 CRK CRKL CSF1R CSF2RB CSF3R CSK DAG1 DDR1 DDR2 DOK1 DUSP23 EGFR EPHA2 EPOR EPS8 ERBB2 ERBB3 ERBB4 ESR1 FAM118B FCGR2A FCGR3A FGFR1 FLT1 FLT4 FYN GAB1 GAB2 GEMIN7 GH1 GHR GRAP GRAP2 GRB2 GRB7 HMOX2 IGF1R IL2 IL2RB IL2RG IL4R IL6ST ILK INPP5D INPPL1 INSR IRS1 IRS2 ITGB3 ITGB4 JAK2 KDR KRT18 LCK LCP2 LRP1 LTK LYN MAP4K1 MAPK1 MAPK14 MAPK6 MAPK8 MAPKAPK2 MET MME MPL MRPL44 MST1R NGFR NPM1 NTRK1 NTRK2 NTRK3 NUDT21 OSGEP PAG1 PAK1 PDGFRB PIK3C2B PIK3R1 PIK3R2 PLCG1 PLCG2 PLSCR1 PPAP2B PPP2R5A PRKCA PRKCD PRKRA PTK2 PTK2B PTPN11 PTPN12 PTPN2 PTPN6 RAPGEF1 RASA1 RET SH2B2 SHCBP1 SOS1 SOS2 SP1 SRC STAT5A STAT5B SUV39H2 SYK TEC TEK TPR VAV1 VAV3 ZAP70	149 interactors: ABL1 ADAM12 ADAMTS2 AGAP2 AKT1 ALK ANK3 ARAF ARHGAP1 ARHGAP17 ARHGAP32 AXL BCAR1 BRCA1 CBL CBLB CCL14 CD19 CD22 CD28 CD2AP CD3E CD4 CD40 CD5 CD7 CDC42 CDH2 CHRNA7 CRK CRKL CSF1R CSF2RA CTLA4 CTNNB1 CXCL2 CYP4A11 DLX2 DNM1 DOK1 EGFR EPHA2 EPOR ERAS ERBB2 ERBB3 ESR1 EZR FASLG FCGR2A FES FGFR1 FYN GAB1 GAB2 GAB3 GHR GRB2 GSK3B GSPT1 GTF2H1 HCK HCST HDAC1 HGS HOXA1 HRAS HTT IFNAR1 IGF1R IL13 IL1R1 IL1RAP IL2RB IL7R INPP4A INSR IRS1 IRS2 IRS4 ITSN1 JAK1 JAK2 JAK3 KHDRBS1 KIT LAT LCK LCP2 MAPK8 MET MME MST1R NFKBIA NTRK1 NTRK2 NUP85 PDGFRA PDGFRB PECAM1 PFN1 PIK3AP1 PIK3CA PIK3CB PIK3CD PPM1A PSEN1 PSMB5 PTK2 PTK2B PTPN11 PTPN6 RAC1 RASA1 RB1 RET RRAS2 SH3KBP1 SHB SHC1 SLC9A2 SOCS1 SOCS6 SOCS7 SRC SSTR2 SYK SYN1 TEC TEK TGFBR1 TGFBR2 TIE1 TLR2 TOM1L1 TRAT1 TSHR TTR TUB TUBA1B TUBG1 TYK2 TYRO3 VAV1 VAV3 WAS WASF3 WBP11 YWHAG
Entrez ID		6464	5295
HPRD ID		02780	01381
Ensembl ID		ENSG00000160691	ENSG00000145675
Uniprot IDs		P29353	P27986
PDB IDs		1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 1WCP 2L1C	1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI 2RD0 2V1Y 3HHM 3HIZ 3I5R 3I5S 4A55
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Positive Regulation Of Signal Transduction Response To Organic Substance Signaling Peptidyl-tyrosine Phosphorylation Cell Communication Cellular Response To Organic Substance Regulation Of Signal Transduction Cellular Response To Stimulus Immune System Process Regulation Of Signaling Intracellular Signal Transduction Response To Stimulus Regulation Of Phosphorylation Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Protein Autophosphorylation Neurotrophin Signaling Pathway Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Regulation Of MAPK Cascade Cellular Response To Growth Factor Stimulus Locomotion Fc Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Innate Immune Response Positive Regulation Of Protein Metabolic Process Immune Response Peptidyl-amino Acid Modification Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Movement Of Cell Or Subcellular Component Positive Regulation Of MAPK Cascade Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Cell Proliferation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Cellular Response To Stimulus Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Signal Transduction Response To Organic Substance Regulation Of Signal Transduction Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Signaling Intracellular Signal Transduction Response To Stimulus Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response Fc Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Regulation Of Kinase Activity Locomotion Defense Response Positive Regulation Of Phosphorylation Response To Growth Factor Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Cellular Response To Growth Factor Stimulus Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Cell Migration Positive Regulation Of Metabolic Process Cell Activation Phosphatidylinositol-mediated Signaling Positive Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Cell Proliferation Cell Motility
Tagcloud ?		adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 rasa1 reasonably relaxed retaining shp2 simulate subdomains tyrosines unphosphorylated	16q 1q affymetrix classic clustering clusters cytoskeleton distinguished epithelium fresh frozen golm1 gpr137b hierarchical ilc lcis lobular mastectomy microarrays microdissected obligate personalize precursor prophylactic supervised transcriptomic triplets u133a unsupervised
Tagcloud (Difference) ?		adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 rasa1 reasonably relaxed retaining shp2 simulate subdomains tyrosines unphosphorylated	16q 1q affymetrix classic clustering clusters cytoskeleton distinguished epithelium fresh frozen golm1 gpr137b hierarchical ilc lcis lobular mastectomy microarrays microdissected obligate personalize precursor prophylactic supervised transcriptomic triplets u133a unsupervised
Tagcloud (Intersection) ?