SHC1 and NTRK2

  • Number of citations of the paper that reports this interaction (PMID 10092678)
  • 41
  • Data Source:
  • BioGRID (pull down)
  • HPRD (in vitro, in vivo)

SHC1

NTRK2

Gene Name SHC (Src homology 2 domain containing) transforming protein 1 neurotrophic tyrosine kinase, receptor, type 2
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions 134 interactors: ALK AP2A1 AP2A2 APP AXL BCL3 BCR C11orf58 CALCOCO2 CALD1 CBL CBLB CBLC CD22 CD247 CD3E CD81 CDH5 CEACAM1 CRK CRKL CSF1R CSF2RB CSF3R CSK DAG1 DDR1 DDR2 DOK1 DUSP23 EGFR EPHA2 EPOR EPS8 ERBB2 ERBB3 ERBB4 ESR1 FAM118B FCGR2A FCGR3A FGFR1 FLT1 FLT4 FYN GAB1 GAB2 GEMIN7 GH1 GHR GRAP GRAP2 GRB2 GRB7 HMOX2 IGF1R IL2 IL2RB IL2RG IL4R IL6ST ILK INPP5D INPPL1 INSR IRS1 IRS2 ITGB3 ITGB4 JAK2 KDR KRT18 LCK LCP2 LRP1 LTK LYN MAP4K1 MAPK1 MAPK14 MAPK6 MAPK8 MAPKAPK2 MET MME MPL MRPL44 MST1R NGFR NPM1 NTRK1 NTRK2 NTRK3 NUDT21 OSGEP PAG1 PAK1 PDGFRB PIK3C2B PIK3R1 PIK3R2 PLCG1 PLCG2 PLSCR1 PPAP2B PPP2R5A PRKCA PRKCD PRKRA PTK2 PTK2B PTPN11 PTPN12 PTPN2 PTPN6 RAPGEF1 RASA1 RET SH2B2 SHCBP1 SOS1 SOS2 SP1 SRC STAT5A STAT5B SUV39H2 SYK TEC TEK TPR VAV1 VAV3 ZAP70 29 interactors: AP1B1 BDNF DOK5 DYNLL1 FRS2 FRS3 FYN GIPC1 KIDINS220 NCK1 NCK2 NGFR NMNAT1 NTF3 NTF4 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB
Entrez ID 6464 4915
HPRD ID 02780 02712
Ensembl ID ENSG00000160691 ENSG00000148053
Uniprot IDs P29353 Q16620 Q548C2 Q5VWE5
PDB IDs 1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 1WCP 2L1C 1HCF 1WWB 4ASZ 4AT3 4AT4 4AT5
Enriched GO Terms of Interacting Partners?
Tagcloud ?
adaptors  assumptions  combinatorial  complexity  cooperativity  dealt  demodification  descriptions  disallow  hinders  hoc  lumped  modelling  obstacle  ode  odes  ordinary  pharmacology  phosphatases  plcgamma1  rasa1  reasonably  relaxed  retaining  shp2  simulate  subdomains  tyrosines  unphosphorylated 
a432t  a452v  ankk1  arrb2  cdh13  chrna2  chrna9  dbh  dnm1  drd2  eas  fagerstrom  gabbr2  grin3a  mstcc  n549s  nrxn1  nrxn2  nrxn3  r480h  rs139982841  rs142807401  rs34755188  rs75981117  skat  tas2r38  v132l  v389l  wss 
Tagcloud (Difference) ?
adaptors  assumptions  combinatorial  complexity  cooperativity  dealt  demodification  descriptions  disallow  hinders  hoc  lumped  modelling  obstacle  ode  odes  ordinary  pharmacology  phosphatases  plcgamma1  rasa1  reasonably  relaxed  retaining  shp2  simulate  subdomains  tyrosines  unphosphorylated 
a432t  a452v  ankk1  arrb2  cdh13  chrna2  chrna9  dbh  dnm1  drd2  eas  fagerstrom  gabbr2  grin3a  mstcc  n549s  nrxn1  nrxn2  nrxn3  r480h  rs139982841  rs142807401  rs34755188  rs75981117  skat  tas2r38  v132l  v389l  wss 
Tagcloud (Intersection) ?