SHC1 and RAPGEF1

Number of citations: 0 (PubMedID 9344843)
Data Source: HPRD (in vivo)

		SHC1	RAPGEF1
Name		SHC adaptor protein 1	Rap guanine nucleotide exchange factor 1
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Focal Adhesion Anchoring Junction Shc-EGFR Complex	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane
	Molecular Function	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phospholipid Binding Receptor Tyrosine Kinase Binding Ephrin Receptor Binding Epidermal Growth Factor Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Heart Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Cell Population Proliferation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Proliferation In Bone Marrow Regulation Of Superoxide Metabolic Process Cell-cell Adhesion	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development Positive Regulation Of Neuron Projection Development Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Establishment Of Endothelial Barrier Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus
Pathways		Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signalling to RAS Signalling to RAS SHC1 events in EGFR signaling Tie2 Signaling Integrin signaling XBP1(S) activates chaperone genes Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade Insulin receptor signalling cascade RET signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Erythropoietin activates RAS Erythropoietin activates RAS Interleukin receptor SHC signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells	Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 RAC3 GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
GWAS		Bipolar disorder ( 31043756 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Eosinophil count ( 29403010 ) Hemoglobin levels ( 32327693 ) Inflammatory bowel disease ( 27569725 ) Prostate cancer ( 23535732 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Cerebrospinal fluid α-synuclein levels ( 29959729 ) Cutaneous malignant melanoma ( 32341527 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Kidney volume ( 34128465 ) Nevus count or cutaneous melanoma ( 32341527 ) Optic disc size ( 31809533 )
Interacting Genes		144 interacting genes: ALK AP2A1 AP2A2 APP AR AXL BCL3 BCR BUB1 C11orf58 CALCOCO2 CALD1 CBL CBLB CBLC CD22 CD247 CD3E CD81 CDH5 CEACAM1 CFTR CRK CRKL CSF1R CSF2RB CSF3R CSK DAG1 DDR1 DDR2 DOK1 DUSP23 EGFR EPHA2 EPOR EPS8 ERBB2 ERBB3 ERBB4 ESR1 FAM118B FBXW7 FCGR2A FCGR3A FGFR1 FGFR2 FLT1 FLT4 FYN GAB1 GAB2 GEMIN7 GH1 GHR GRAP GRAP2 GRB2 GRB7 HMOX2 IGF1R IL2 IL2RB IL2RG IL4R IL6ST ILK INPP5D INPPL1 INSR IRS1 IRS2 ITGB3 ITGB4 JAK2 KDR KIT KRT18 LCK LCP2 LRP1 LTK LYN MAP4K1 MAPK1 MAPK14 MAPK6 MAPK8 MAPKAPK2 MET MME MPL MRPL44 MST1R NGFR NPM1 NTRK1 NTRK2 NTRK3 NUDT21 OSGEP PAG1 PAK1 PDGFRB PIK3C2B PIK3R1 PIK3R2 PLCG1 PLCG2 PLPP3 PLSCR1 PPP2R5A PRKCA PRKCD PRKRA PTK2 PTK2B PTPN11 PTPN12 PTPN2 PTPN6 RAPGEF1 RASA1 RB1 RET SH2B2 SHCBP1 SMAD4 SOS1 SOS2 SP1 SRC STAT5A STAT5B SUV39H2 SYK TEC TEK TPR TRIM15 UBASH3B VAV1 VAV3 ZAP70	19 interacting genes: ABL1 ATXN1 BCAR1 CRK CRKL EGFR GRB2 HCK HRAS MBIP NEDD9 RAP1A RAP1B RAP2B RHOQ RPS15 RRAS2 SHC1 SLC20A1
Entrez ID		6464	2889
HPRD ID		02780	02627
Ensembl ID		ENSG00000160691	ENSG00000107263
Uniprot IDs		P29353	A0A1S5UYZ7 A0A804HL87 Q13905
PDB IDs		1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 2L1C 4JMH 4XWX 5CZI 6DM4	5L23
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Receptor Complex Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Plasma Membrane Positive Regulation Of MAPK Cascade Protein Phosphorylation Positive Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Phosphorylation Phosphotyrosine Residue Binding Intracellular Signal Transduction Regulation Of Developmental Process Protein Autophosphorylation Immune System Process Regulation Of Immune Response Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Intracellular Signaling Cassette Response To Growth Factor Cell Activation Cytokine-mediated Signaling Pathway Positive Regulation Of Immune System Process Cell Migration Regulation Of Apoptotic Process Positive Regulation Of Cell Migration Regulation Of Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Cell Motility	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Phosphotyrosine Residue Binding Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Small GTPase-mediated Signal Transduction Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Regulation Of Actin Filament-based Process Positive Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Locomotion Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus ERBB Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Signaling Pathway GDP Binding Regulation Of Protein Localization To Membrane Regulation Of Cell Migration Response To Growth Factor Regulation Of Cell Motility Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Locomotion Positive Regulation Of Signaling Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Rap Protein Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Migration Focal Adhesion Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading Antigen Receptor-mediated Signaling Pathway Plasma Membrane Regulation Of Lymphocyte Migration Cytosol Cell Motility GTPase Activity