SHC1 and LTK

Number of citations: 0 (PubMedID 9223670)
Data Source: HPRD (in vitro)

		SHC1	LTK
Name		SHC adaptor protein 1	leukocyte receptor tyrosine kinase
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Focal Adhesion Anchoring Junction Shc-EGFR Complex	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phospholipid Binding Receptor Tyrosine Kinase Binding Ephrin Receptor Binding Epidermal Growth Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity
	Biological Process	Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Heart Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Cell Population Proliferation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Proliferation In Bone Marrow Regulation Of Superoxide Metabolic Process Cell-cell Adhesion	Protein Phosphorylation Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Population Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Retinoic Acid
Pathways		Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signalling to RAS Signalling to RAS SHC1 events in EGFR signaling Tie2 Signaling Integrin signaling XBP1(S) activates chaperone genes Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade Insulin receptor signalling cascade RET signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Erythropoietin activates RAS Erythropoietin activates RAS Interleukin receptor SHC signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells	Signaling by LTK
Drugs		None	Fostamatinib
GWAS		Bipolar disorder ( 31043756 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Eosinophil count ( 29403010 ) Hemoglobin levels ( 32327693 ) Inflammatory bowel disease ( 27569725 ) Prostate cancer ( 23535732 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	High density lipoprotein cholesterol levels ( 31928498 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Lymphocyte percentage of white cells ( 32888494 ) Type 2 diabetes ( 30297969 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 )
Interacting Genes		144 interacting genes: ALK AP2A1 AP2A2 APP AR AXL BCL3 BCR BUB1 C11orf58 CALCOCO2 CALD1 CBL CBLB CBLC CD22 CD247 CD3E CD81 CDH5 CEACAM1 CFTR CRK CRKL CSF1R CSF2RB CSF3R CSK DAG1 DDR1 DDR2 DOK1 DUSP23 EGFR EPHA2 EPOR EPS8 ERBB2 ERBB3 ERBB4 ESR1 FAM118B FBXW7 FCGR2A FCGR3A FGFR1 FGFR2 FLT1 FLT4 FYN GAB1 GAB2 GEMIN7 GH1 GHR GRAP GRAP2 GRB2 GRB7 HMOX2 IGF1R IL2 IL2RB IL2RG IL4R IL6ST ILK INPP5D INPPL1 INSR IRS1 IRS2 ITGB3 ITGB4 JAK2 KDR KIT KRT18 LCK LCP2 LRP1 LTK LYN MAP4K1 MAPK1 MAPK14 MAPK6 MAPK8 MAPKAPK2 MET MME MPL MRPL44 MST1R NGFR NPM1 NTRK1 NTRK2 NTRK3 NUDT21 OSGEP PAG1 PAK1 PDGFRB PIK3C2B PIK3R1 PIK3R2 PLCG1 PLCG2 PLPP3 PLSCR1 PPP2R5A PRKCA PRKCD PRKRA PTK2 PTK2B PTPN11 PTPN12 PTPN2 PTPN6 RAPGEF1 RASA1 RB1 RET SH2B2 SHCBP1 SMAD4 SOS1 SOS2 SP1 SRC STAT5A STAT5B SUV39H2 SYK TEC TEK TPR TRIM15 UBASH3B VAV1 VAV3 ZAP70	6 interacting genes: CBL DUSP6 MTMR14 PIK3C2B PTPN1 SHC1
Entrez ID		6464	4058
HPRD ID		02780	01052
Ensembl ID		ENSG00000160691	ENSG00000062524
Uniprot IDs		P29353	P29376
PDB IDs		1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 2L1C 4JMH 4XWX 5CZI 6DM4	7NX0 7NX1
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Receptor Complex Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Plasma Membrane Positive Regulation Of MAPK Cascade Protein Phosphorylation Positive Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Phosphorylation Phosphotyrosine Residue Binding Intracellular Signal Transduction Regulation Of Developmental Process Protein Autophosphorylation Immune System Process Regulation Of Immune Response Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Intracellular Signaling Cassette Response To Growth Factor Cell Activation Cytokine-mediated Signaling Pathway Positive Regulation Of Immune System Process Cell Migration Regulation Of Apoptotic Process Positive Regulation Of Cell Migration Regulation Of Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Cell Motility	Ephrin Receptor Binding Receptor Tyrosine Kinase Binding Response To Growth Factor Response To Platelet-derived Growth Factor Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Dephosphorylation Insulin Receptor Binding Cellular Response To Growth Factor Stimulus Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Phosphotyrosine Residue Binding Negative Regulation Of ERK1 And ERK2 Cascade Insulin Receptor Signaling Pathway Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Response To Nutrient Levels Protein Tyrosine Phosphatase Activity Phosphate-containing Compound Metabolic Process Phosphatidylinositol Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Shc-EGFR Complex Cellular Response To Hypoxia Cytosol Phosphoprotein Phosphatase Activity Dephosphorylation Phosphatidylinositol Metabolic Process Cellular Response To Decreased Oxygen Levels Response To Stress Regulation Of MAPK Cascade Cellular Response To Oxygen Levels Regulation Of Rap Protein Signal Transduction Negative Regulation Of MAPK Cascade Macroautophagy Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Insulin Receptor Recycling Positive Regulation Of Cell Proliferation In Bone Marrow Epidermal Growth Factor Binding Intracellular Signal Transduction Glycerophospholipid Biosynthetic Process Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Regulation Of Cell Proliferation In Bone Marrow Ubiquitin-dependent Endocytosis MAP Kinase Tyrosine Phosphatase Activity Lipid Kinase Activity Sorting Endosome Neurotrophin TRKA Receptor Binding Regulation Of Intracellular Signal Transduction