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NFKB1 and YWHAQ
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
NFKB1
YWHAQ
Description
nuclear factor kappa B subunit 1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Image
GO Annotations
Cellular Component
Chromatin
Extracellular Region
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
I-kappaB/NF-kappaB Complex
Secretory Granule Lumen
NF-kappaB P50/p65 Complex
Specific Granule Lumen
Nucleus
Cytoplasm
Cytosol
Focal Adhesion
Membrane
Protein-containing Complex
Synapse
Extracellular Exosome
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Transcription Coregulator Activity
Protein Binding
Identical Protein Binding
Actinin Binding
Sequence-specific DNA Binding
Protein Sequestering Activity
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Transmembrane Transporter Binding
14-3-3 Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Negative Regulation Of Cytokine Production
Immune System Process
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Apoptotic Process
Inflammatory Response
Signal Transduction
Canonical NF-kappaB Signal Transduction
JNK Cascade
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Efflux
Positive Regulation Of Lipid Storage
Negative Regulation Of Vitamin D Biosynthetic Process
Signal Transduction Involved In Regulation Of Gene Expression
Negative Regulation Of Interleukin-12 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Muscle Stretch
Non-canonical NF-kappaB Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
B Cell Receptor Signaling Pathway
Mammary Gland Involution
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Nicotine
Cellular Response To Cytokine Stimulus
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Cellular Response To DsRNA
Positive Regulation Of Canonical Wnt Signaling Pathway
Cellular Response To Interleukin-17
Cellular Response To Virus
Antibacterial Innate Immune Response
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Hyaluronan Biosynthetic Process
Cellular Response To Angiotensin
Positive Regulation Of MiRNA Metabolic Process
Protein Targeting
Signal Transduction
Small GTPase-mediated Signal Transduction
Intracellular Protein Localization
Substantia Nigra Development
Negative Regulation Of Monoatomic Ion Transmembrane Transport
Negative Regulation Of DNA-templated Transcription
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
Transcriptional regulation of white adipocyte differentiation
TAK1-dependent IKK and NF-kappa-B activation
Interleukin-1 processing
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
CLEC7A/inflammasome pathway
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neutrophil degranulation
The NLRP3 inflammasome
Transcriptional Regulation by VENTX
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
HCMV Early Events
Purinergic signaling in leishmaniasis infection
SARS-CoV-1 activates/modulates innate immune responses
Regulation of NFE2L2 gene expression
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Regulation of PD-L1(CD274) transcription
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Drugs
Sulfasalazine
Donepezil
Pseudoephedrine
Pranlukast
Pranlukast
HE3286
P54
NOX-700
SGN-30
Custirsen
NF-kappaB Decoy
Andrographolide
Triflusal
Terpinen-4-ol
Glycyrrhizic acid
Fish oil
SC-236
Phenethyl Isothiocyanate
Diseases
GWAS
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic rhinitis (
30013184
)
Allergic sensitization (
30013184
)
Basophil percentage of white cells (
32888494
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Copper levels (
26025379
)
Creatinine levels (
29124443
)
Crohn's disease (
28067908
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Estimated glomerular filtration rate (
29124443
30604766
)
Glomerular filtration rate (creatinine) (
26831199
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Homeostasis model assessment of beta-cell function (dietary factor interaction) (
24204828
)
Immature fraction of reticulocytes (
32888494
)
Inflammatory bowel disease (
28067908
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (thyroid preparations) (
31015401
)
Membranous nephropathy (
32231244
)
Monocyte percentage of white cells (
27863252
)
Multiple sclerosis (
21833088
)
Neutrophil percentage of granulocytes (
27863252
)
Neutrophil percentage of white cells (
32888494
27863252
)
Non-albumin protein levels (
29403010
)
Primary biliary cholangitis (
28425483
23000144
26394269
28062665
21399635
30643196
)
Primary biliary cirrhosis (
22961000
)
Primary sclerosing cholangitis (
27992413
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Schizophrenia (treatment resistant) (
22479419
)
Serum total protein levels (
29403010
)
Serum uric acid levels (
29124443
)
Sum eosinophil basophil counts (
27863252
)
Systemic sclerosis (
31672989
30247649
)
Tonsillectomy (
27182965
28928442
)
Ulcerative colitis (
23128233
)
White blood cell count (
32888494
)
Heart rate variability traits (
22174390
)
Non-response to selective serotonin reuptake inhibitors and depression (
27622933
)
Interacting Genes
106 interacting genes:
ABCC2
APBB2
AR
ATF3
BARD1
BCL3
BRCA1
BTRC
CDK9
CEBPB
CFLAR
CHUK
COPB2
COPS5
CTNNB1
DNMT3L
E2F1
ECSIT
ELF1
ELF3
ESR1
ETS1
FBXO7
FBXW11
FOS
G3BP2
GLUL
GSK3B
HDAC1
HMGA1
HMGA2
HMGB1
HSPA4
IKBKB
IKBKG
IL2RA
IRF1
IRF2
IRF8
IRF9
ITGB3BP
KAT5
KLF5
KPNA3
LYL1
MAP3K8
MEN1
MTPN
NCOA1
NCOA6
NCOR2
NFKB2
NFKBIA
NFKBIB
NFKBIE
NFKBIZ
NFRKB
NKRF
NOTCH1
NR3C1
NR4A1
PALS2
PARP1
PCBD1
PDCD11
PELP1
PLD3
PML
PPARG
PPP4C
PRKACA
PSMD10
REL
RELA
RELB
RGS14
RIPK1
RPS3
RSF1
RXRA
SERPINA3
SF1
SIN3A
SP1
SPAG9
SPI1
SPPL2A
SRF
STAT3
STAT6
TAB2
TFAP2A
TNFSF11
TNIP2
TP53BP1
TP53BP2
TRIP4
TSC22D3
TXN
UBE2D2
UBE2D3
UBE2K
UNC5CL
YWHAQ
YY1
ZBTB9
216 interacting genes:
AARS2
ABL1
ACSL4
ADRB2
AGTR1
AHCY
AKT1S1
ANXA1
ANXA2
AR
ARHGAP10
ARHGEF16
ATP5F1A
BAD
BAX
BCAP31
BCR
BRAF
CABIN1
CAPN3
CBL
CBLL1
CCDC125
CDC25A
CDC25B
CDC25C
CDC5L
CDK11B
CDK14
CDK16
CDKN1A
CDKN1B
CFL1
CHAF1A
CKM
CLTC
COPS4
CSE1L
CSNK1A1
CSNK2A1
CTPS1
DAB2IP
DCPS
DDX1
DDX3X
DHX9
DISC1
DNMT1
DYNC1H1
E2F1
EFNB1
EGFR
EIF4A3
ENO1
EPB41
EPB41L1
EPB41L3
ESR1
ESR2
FASN
FBLN1
FGR
FSCN1
FSHR
FXYD1
GAPDH
GCN1
H2BC8
H4C14
HADHA
HAT1
HAX1
HDAC7
HNRNPC
HNRNPH1
HSPA1A
HSPA8
HSPB1
HUS1
IARS2
ING1
ITCH
ITGB4
KANK1
KCNK15
KCNK3
KCNK9
KIF5B
KLC2
KLC3
KRT1
KRT9
LARP1
LARS2
LDHA
LIMA1
LMNA
LMNB1
LYST
MAGOH
MAP3K3
MAP3K5
MCM3
MDM4
MED1
MEF2D
MPL
MPRIP
MRPS27
MST1R
MTNR1B
MTOR
MYCBP2
NADK
NCL
NCOA1
NCOA3
NDE1
NEDD4L
NFATC1
NFATC2
NFATC4
NFKB1
NIF3L1
NME7
NOLC1
NUMA1
PABPN1
PANK1
PDCD6
PDE3A
PDE3B
PDE4B
PDK1
PDPK1
PDXK
PFKFB2
PFKL
PFN1
PGK1
PHLDB2
PI4KB
PIK3C3
PIK3CB
PKM
PRDX1
PRKCQ
PRKCZ
PRKD1
PRKDC
PRMT5
PSME3
RAI14
RCOR3
REM1
RFC1
RGS3
RGS7
RIPK2
RNASE2
RPL10A
RPL15
RPL19
RPL7
RPLP0
RPLP2
RPS3
RUVBL2
SAMSN1
SH3BP2
SKIC8
SLC27A2
SLC8A1
SLC8A2
SLC8A3
SMAD9
SNRPE
SOCS3
SPR
SPTA1
SPTB
SRSF3
SSBP1
SSX2IP
SUMO2
TCP1
TERT
THRA
TLN1
TNF
TNFAIP3
TPI1
TPR
TRAF6
TRIM25
TRIM28
TRIM42
TSC1
TSC2
TUBA1A
TUBA3C
TUBB
UBQLN4
UCP2
UCP3
ULK4
USP8
VARS1
WDR77
WTAP
WWC2
WWP1
YAP1
YWHAG
ZC3H13
ZHX2
Entrez ID
4790
10971
HPRD ID
01238
00886
Ensembl ID
ENSG00000109320
ENSG00000134308
Uniprot IDs
P19838
P27348
PDB IDs
1MDI
1MDJ
1MDK
1NFI
1SVC
2DBF
2O61
3GUT
7LEQ
7LET
7LF4
7LFC
7RG4
7RG5
8TQD
2BTP
5IQP
6BCR
6BD2
6BQT
6KZG
6KZH
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Gene Expression
Nucleoplasm
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Nucleus
Chromatin
Transcription Cis-regulatory Region Binding
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Response To Stress
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
Regulation Of Apoptotic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Regulation Of Programmed Cell Death
Negative Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Factor Activity
Intracellular Signal Transduction
Response To Cytokine
Response To Peptide
Sequence-specific DNA Binding
Regulation Of Intracellular Signal Transduction
Canonical NF-kappaB Signal Transduction
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Non-canonical NF-kappaB Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Developmental Process
Transcription Regulator Complex
Cytosol
Cytoplasm
Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Protein Metabolic Process
ATP Binding
Regulation Of Cellular Component Organization
Regulation Of Primary Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Positive Regulation Of Metabolic Process
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of Metabolic Process
Nucleus
Cadherin Binding
Kinase Activity
Negative Regulation Of Programmed Cell Death
Regulation Of Developmental Process
Nucleobase-containing Compound Metabolic Process
Cellular Response To Stress
Nucleotide Binding
Regulation Of Biological Quality
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Protein Metabolic Process
Cell Cortex
Cellular Response To Oxygen-containing Compound
Response To Stress
Protein-containing Complex
Glucose Catabolic Process
Organelle Organization
Positive Regulation Of Multicellular Organismal Process
Macromolecule Metabolic Process
ADP Metabolic Process
RNA Binding
Cellular Response To Lipid
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Extracellular Exosome
Regulation Of Organelle Organization
Positive Regulation Of Cell Population Proliferation
Glycolytic Process
Cellular Response To Hormone Stimulus
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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