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NFKB1 and TAB2
Number of citations of the paper that reports this interaction (PubMedID
12150997
)
0
Data Source:
BioGRID
(pull down, affinity chromatography technology)
NFKB1
TAB2
Description
nuclear factor kappa B subunit 1
TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Image
GO Annotations
Cellular Component
Chromatin
Extracellular Region
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
I-kappaB/NF-kappaB Complex
Secretory Granule Lumen
NF-kappaB P50/p65 Complex
Specific Granule Lumen
Nucleoplasm
Cytoplasm
Lysosome
Lysosomal Membrane
Endosome
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Transcription Coregulator Activity
Protein Binding
Identical Protein Binding
Actinin Binding
Sequence-specific DNA Binding
Protein Sequestering Activity
Protein Binding
Zinc Ion Binding
Ubiquitin Binding
Metal Ion Binding
Molecular Adaptor Activity
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Negative Regulation Of Cytokine Production
Immune System Process
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Apoptotic Process
Inflammatory Response
Signal Transduction
Canonical NF-kappaB Signal Transduction
JNK Cascade
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Efflux
Positive Regulation Of Lipid Storage
Negative Regulation Of Vitamin D Biosynthetic Process
Signal Transduction Involved In Regulation Of Gene Expression
Negative Regulation Of Interleukin-12 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Muscle Stretch
Non-canonical NF-kappaB Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
B Cell Receptor Signaling Pathway
Mammary Gland Involution
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Nicotine
Cellular Response To Cytokine Stimulus
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Cellular Response To DsRNA
Positive Regulation Of Canonical Wnt Signaling Pathway
Cellular Response To Interleukin-17
Cellular Response To Virus
Antibacterial Innate Immune Response
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Hyaluronan Biosynthetic Process
Cellular Response To Angiotensin
Positive Regulation Of MiRNA Metabolic Process
Inflammatory Response
Canonical NF-kappaB Signal Transduction
Heart Development
Response To Bacterium
Negative Regulation Of Autophagy
Response To Lipopolysaccharide
Non-canonical NF-kappaB Signal Transduction
P38MAPK Cascade
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Protein Kinase Activity
Protein K63-linked Ubiquitination
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
Transcriptional regulation of white adipocyte differentiation
TAK1-dependent IKK and NF-kappa-B activation
Interleukin-1 processing
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
CLEC7A/inflammasome pathway
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neutrophil degranulation
The NLRP3 inflammasome
Transcriptional Regulation by VENTX
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
HCMV Early Events
Purinergic signaling in leishmaniasis infection
SARS-CoV-1 activates/modulates innate immune responses
Regulation of NFE2L2 gene expression
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Regulation of PD-L1(CD274) transcription
Nuclear signaling by ERBB4
Nuclear signaling by ERBB4
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NF-kappa-B signaling pathway
CLEC7A (Dectin-1) signaling
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Sulfasalazine
Donepezil
Pseudoephedrine
Pranlukast
Pranlukast
HE3286
P54
NOX-700
SGN-30
Custirsen
NF-kappaB Decoy
Andrographolide
Triflusal
Terpinen-4-ol
Glycyrrhizic acid
Fish oil
SC-236
Diseases
GWAS
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic rhinitis (
30013184
)
Allergic sensitization (
30013184
)
Basophil percentage of white cells (
32888494
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Copper levels (
26025379
)
Creatinine levels (
29124443
)
Crohn's disease (
28067908
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Estimated glomerular filtration rate (
29124443
30604766
)
Glomerular filtration rate (creatinine) (
26831199
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Homeostasis model assessment of beta-cell function (dietary factor interaction) (
24204828
)
Immature fraction of reticulocytes (
32888494
)
Inflammatory bowel disease (
28067908
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (thyroid preparations) (
31015401
)
Membranous nephropathy (
32231244
)
Monocyte percentage of white cells (
27863252
)
Multiple sclerosis (
21833088
)
Neutrophil percentage of granulocytes (
27863252
)
Neutrophil percentage of white cells (
32888494
27863252
)
Non-albumin protein levels (
29403010
)
Primary biliary cholangitis (
28425483
23000144
26394269
28062665
21399635
30643196
)
Primary biliary cirrhosis (
22961000
)
Primary sclerosing cholangitis (
27992413
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Schizophrenia (treatment resistant) (
22479419
)
Serum total protein levels (
29403010
)
Serum uric acid levels (
29124443
)
Sum eosinophil basophil counts (
27863252
)
Systemic sclerosis (
31672989
30247649
)
Tonsillectomy (
27182965
28928442
)
Ulcerative colitis (
23128233
)
White blood cell count (
32888494
)
Breast cancer (
22383897
29059683
)
Coronary artery disease (
33020668
)
Diverticulitis (
28585551
)
Dupuytren's disease (
21732829
28886342
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Interacting Genes
106 interacting genes:
ABCC2
APBB2
AR
ATF3
BARD1
BCL3
BRCA1
BTRC
CDK9
CEBPB
CFLAR
CHUK
COPB2
COPS5
CTNNB1
DNMT3L
E2F1
ECSIT
ELF1
ELF3
ESR1
ETS1
FBXO7
FBXW11
FOS
G3BP2
GLUL
GSK3B
HDAC1
HMGA1
HMGA2
HMGB1
HSPA4
IKBKB
IKBKG
IL2RA
IRF1
IRF2
IRF8
IRF9
ITGB3BP
KAT5
KLF5
KPNA3
LYL1
MAP3K8
MEN1
MTPN
NCOA1
NCOA6
NCOR2
NFKB2
NFKBIA
NFKBIB
NFKBIE
NFKBIZ
NFRKB
NKRF
NOTCH1
NR3C1
NR4A1
PALS2
PARP1
PCBD1
PDCD11
PELP1
PLD3
PML
PPARG
PPP4C
PRKACA
PSMD10
REL
RELA
RELB
RGS14
RIPK1
RPS3
RSF1
RXRA
SERPINA3
SF1
SIN3A
SP1
SPAG9
SPI1
SPPL2A
SRF
STAT3
STAT6
TAB2
TFAP2A
TNFSF11
TNIP2
TP53BP1
TP53BP2
TRIP4
TSC22D3
TXN
UBE2D2
UBE2D3
UBE2K
UNC5CL
YWHAQ
YY1
ZBTB9
44 interacting genes:
APP
CAMK2A
CST9L
EIF2AK2
EMILIN1
ERBB4
FN1
FOSL1
GTF2I
HDAC1
HDAC3
HDAC5
HSF2BP
IKBKB
IKBKG
IRAK1
KRT85
MAP3K7
NCOR1
NFKB1
NR2C2
NUMBL
PPIL3
PPP2CB
SLC19A3
TAB1
TBL1X
TGM2
TNFRSF11A
TPM3
TRAF2
TRAF3IP1
TRAF6
TRIM45
TTN
UBC
UBE2I
VIM
VPS52
XIAP
YWHAZ
ZBTB16
ZFP64
ZNF143
Entrez ID
4790
23118
HPRD ID
01238
05483
Ensembl ID
ENSG00000109320
ENSG00000055208
Uniprot IDs
P19838
B4DIR9
Q9NYJ8
PDB IDs
1MDI
1MDJ
1MDK
1NFI
1SVC
2DBF
2O61
3GUT
7LEQ
7LET
7LF4
7LFC
7RG4
7RG5
8TQD
2DAE
2WWZ
2WX0
2WX1
9AVT
9AVW
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Gene Expression
Nucleoplasm
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Nucleus
Chromatin
Transcription Cis-regulatory Region Binding
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Response To Stress
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
Regulation Of Apoptotic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Regulation Of Programmed Cell Death
Negative Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Factor Activity
Intracellular Signal Transduction
Response To Cytokine
Response To Peptide
Sequence-specific DNA Binding
Regulation Of Intracellular Signal Transduction
Canonical NF-kappaB Signal Transduction
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Non-canonical NF-kappaB Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Developmental Process
Transcription Regulator Complex
Canonical NF-kappaB Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signaling
Regulation Of Gene Expression
Regulation Of Signal Transduction
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of JNK Cascade
Response To External Biotic Stimulus
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Defense Response
Positive Regulation Of Metabolic Process
Defense Response
Regulation Of Signaling
Positive Regulation Of Defense Response
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cell Communication
Identical Protein Binding
Regulation Of Macromolecule Metabolic Process
Protein Modification Process
Positive Regulation Of Multicellular Organismal Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Histone Deacetylase Complex
Cytokine-mediated Signaling Pathway
Regulation Of Cytokine Production
Negative Regulation Of Macromolecule Biosynthetic Process
Cytosol
Toll-like Receptor Signaling Pathway
Positive Regulation Of MAPK Cascade
Negative Regulation Of Biosynthetic Process
Pattern Recognition Receptor Signaling Pathway
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Immune Response-activating Signaling Pathway
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Regulation Of DNA-templated Transcription
Innate Immune Response-activating Signaling Pathway
Response To Other Organism
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Tagcloud (Intersection)
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