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ATM and PARP1
Number of citations of the paper that reports this interaction (PubMedID
35575683
)
0
Data Source:
BioGRID
(cross-linking study, pull down)
ATM
PARP1
Description
ATM serine/threonine kinase
poly(ADP-ribose) polymerase 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Peroxisome
Peroxisomal Matrix
Centrosome
Spindle
Cytosol
Cytoskeleton
Cytoplasmic Vesicle
Site Of Double-strand Break
Extrinsic Component Of Synaptic Vesicle Membrane
DNA Repair Complex
Chromosome, Telomeric Region
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Transcription Regulator Complex
Chromosome
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Membrane
Nuclear Body
Protein-containing Complex
Protein-DNA Complex
Site Of Double-strand Break
Nuclear Replication Fork
Site Of DNA Damage
Molecular Function
Nucleotide Binding
DNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
1-phosphatidylinositol-3-kinase Activity
Transferase Activity
Histone H2AXS139 Kinase Activity
Identical Protein Binding
Protein-containing Complex Binding
Protein Serine Kinase Activity
DNA Binding
Chromatin Binding
Damaged DNA Binding
RNA Binding
Catalytic Activity
NAD+ Poly-ADP-ribosyltransferase Activity
Protein Binding
Enzyme Activator Activity
Zinc Ion Binding
Transferase Activity
Glycosyltransferase Activity
Nucleotidyltransferase Activity
Enzyme Binding
Protein Kinase Binding
Nuclear Estrogen Receptor Binding
Nucleosome Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
Metal Ion Binding
NAD Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
R-SMAD Binding
NAD DNA ADP-ribosyltransferase Activity
Transcription Regulator Activator Activity
NAD+-protein-serine ADP-ribosyltransferase Activity
NAD+-protein-aspartate ADP-ribosyltransferase Activity
NAD+-protein-glutamate ADP-ribosyltransferase Activity
NAD+-protein-tyrosine ADP-ribosyltransferase Activity
NAD+-protein-histidine ADP-ribosyltransferase Activity
NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity
NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity
NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity
NAD+-protein Mono-ADP-ribosyltransferase Activity
Biological Process
Autophagosome Assembly
DNA Damage Checkpoint Signaling
Pexophagy
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
Ovarian Follicle Development
Somitogenesis
Pre-B Cell Allelic Exclusion
Immune System Process
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Chromatin Remodeling
Protein Phosphorylation
Protein Monoubiquitination
DNA Damage Response
Response To Oxidative Stress
Mitotic Spindle Assembly Checkpoint Signaling
Mitotic G2 DNA Damage Checkpoint Signaling
Meiosis I
Reciprocal Meiotic Recombination
Male Meiotic Nuclear Division
Female Meiotic Nuclear Division
Signal Transduction
Female Gamete Generation
Brain Development
Heart Development
Determination Of Adult Lifespan
Female Gonad Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Post-embryonic Development
Response To Ionizing Radiation
Regulation Of Gene Expression
Regulation Of Autophagy
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
V(D)J Recombination
Cellular Response To Stress
Cellular Response To Reactive Oxygen Species
Multicellular Organism Growth
Phosphatidylinositol-3-phosphate Biosynthetic Process
Peptidyl-serine Autophosphorylation
Lipoprotein Catabolic Process
Response To Starvation
Signal Transduction In Response To DNA Damage
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Neuron Apoptotic Process
Meiotic Telomere Clustering
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
Thymus Development
Oocyte Development
Protein Stabilization
Neuron Apoptotic Process
Regulation Of Cell Cycle
Chromosome Organization Involved In Meiotic Cell Cycle
Protein K63-linked Ubiquitination
Histone MRNA Catabolic Process
Cellular Response To Retinoic Acid
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Cellular Response To Nitrosative Stress
Regulation Of Cellular Response To Stress
Cellular Senescence
Replicative Senescence
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of Cellular Response To Heat
Cellular Response To Oxygen-containing Compound
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of TORC1 Signaling
Negative Regulation Of Telomere Capping
Positive Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Protein Localization To Site Of Double-strand Break
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Double-strand Break Repair
Regulation Of Autophagosome Assembly
Positive Regulation Of Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Immune System Process
DNA Repair
Double-strand Break Repair
Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Mitochondrion Organization
Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Gamma Radiation
Positive Regulation Of Cardiac Muscle Hypertrophy
Carbohydrate Biosynthetic Process
Protein Autoprocessing
Signal Transduction Involved In Regulation Of Gene Expression
Macrophage Differentiation
DNA ADP-ribosylation
Mitochondrial DNA Metabolic Process
Positive Regulation Of DNA-templated Transcription, Elongation
Cellular Response To Insulin Stimulus
Regulation Of Protein Localization
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Cellular Response To Oxidative Stress
Cellular Response To UV
Protein Modification Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Mitochondrial DNA Repair
Innate Immune Response
Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep
Negative Regulation Of Innate Immune Response
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Decidualization
Positive Regulation Of Mitochondrial Depolarization
Positive Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Necroptotic Process
Protein Poly-ADP-ribosylation
Protein Auto-ADP-ribosylation
Protein Localization To Chromatin
Cellular Response To Zinc Ion
Cellular Response To Transforming Growth Factor Beta Stimulus
Replication Fork Reversal
DNA Repair-dependent Chromatin Remodeling
Negative Regulation Of CGAS/STING Signaling Pathway
Transcription Pausing By RNA Polymerase II
Positive Regulation Of Protein Localization To Nucleus
Cellular Response To Oxygen-containing Compound
Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Response To Aldosterone
Negative Regulation Of Adipose Tissue Development
Positive Regulation Of Adipose Tissue Development
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Cellular Response To Amyloid-beta
Positive Regulation Of Myofibroblast Differentiation
Regulation Of Base-excision Repair
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Cellular Response To Nerve Growth Factor Stimulus
Protein Localization To Site Of Double-strand Break
ATP Generation From Poly-ADP-D-ribose
Negative Regulation Of ATP Biosynthetic Process
Pathways
DNA Damage/Telomere Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
Autodegradation of the E3 ubiquitin ligase COP1
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 Regulates Transcription of Caspase Activators and Caspases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
G2/M DNA damage checkpoint
Stabilization of p53
Meiotic recombination
Pexophagy
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
POLB-Dependent Long Patch Base Excision Repair
vRNA Synthesis
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SUMOylation of DNA damage response and repair proteins
HDR through MMEJ (alt-NHEJ)
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Drugs
Caffeine
Theophylline
Zinc
Carba-nicotinamide-adenine-dinucleotide
NU1025
Nicotinamide
2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone
3-Methoxybenzamide
2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide
3,4-Dihydro-5-Methyl-Isoquinolinone
2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide
6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE
Veliparib
A-620223
5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
Olaparib
Talazoparib
Niraparib
Rucaparib
Iniparib
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Ataxia telangiectasia (AT); Louis-Bar syndrome; Boder-Sedgwick syndrome
Chronic lymphocytic leukemia (CLL)
Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Alzheimer's disease (late onset) (
28714976
)
Cutaneous malignant melanoma (
32341527
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of white cells (
27863252
32888494
)
Gastric adenocarcinoma (histologically verified) (
26098866
)
Gastric cancer (
26098866
)
Leukocyte telomere length (
32109421
31171785
)
Lymphocyte count (
32888494
)
Mean reticulocyte volume (
32888494
)
Melanoma (
21983787
28212542
)
Myeloproliferative neoplasms (
33057200
)
Nevus count or cutaneous melanoma (
30429480
32341527
)
Nonunion in individuals with fractures (
30680360
)
Prostate cancer (
29892016
)
Red blood cell count (
29403010
)
Refractive error (
32231278
)
Renal cell carcinoma (
28598434
)
Response to metformin in type 2 diabetes (glycemic) (
21186350
)
Rheumatoid arthritis (
30423114
24390342
)
Sum eosinophil basophil counts (
27863252
)
Uterine fibroids (
30194396
)
Coronary artery disease (
29212778
)
Leukocyte telomere length (
31171785
32109421
)
Melanoma (
21983785
)
Mild to moderate chronic kidney disease (
31178898
)
Nevus count or cutaneous melanoma (
30429480
32341527
)
Platelet count (
29403010
)
Telomere length (
29151059
)
Interacting Genes
135 interacting genes:
AATF
ABL1
ACTL6B
AP1B1
AP2B1
AP3B1
AP3B2
APBB1
ATR
BCAS3
BCL10
BRCA1
CDC6
CDKN2C
CDX2
CHD4
CHEK1
CHEK2
CHUK
COPS5
CREB1
CRX
CSNK1A1
CSNK1D
CTTN
CXXC5
CYREN
DAXX
DCAF1
DCK
DCLRE1C
DDX1
DYRK2
E2F1
E4F1
EEF1E1
EIF3E
EIF4EBP1
EP400
EPHA5
ERRFI1
ESRRG
EXO1
FANCD2
FECH
FUS
H1-2
H2AX
HIF1A
HMGA1
HSPA8
IL24
KAT5
KAT8
KPNA1
KPNA3
KPNA5
LCOR
LIG4
MAP1S
MAPK1
MAPK14
MAPK8
MCM2
MCPH1
MDC1
MDM2
MDM4
MRE11
MT-ND4
MTA3
MUC1
NBN
NFE2L2
NHEJ1
NPM1
NR4A1
NREP
NSD3
OSGIN1
PAN2
PARP1
PCNA
PEX5
PIDD1
POLL
POLR2A
PPP2R1A
PPP2R5C
PRKAA1
PRKDC
PTCH1
PTEN
RAD17
RAD50
RAD51
RAD9A
RANBP9
RASSF1
RBBP8
RHEB
RNF20
RNF40
RPA1
RPA2
RPS6KA1
RPS6KA3
SIN3A
SMARCA4
SMC1A
SPOP
SPSB1
STK11
TCL1A
TERF1
TERF2
TFF1
TIPARP
TOP1
TOP2A
TOPBP1
TP53
TP53BP1
TRAF6
TREX1
TRIM29
TTI1
UCHL3
USP37
VAC14
WRN
XPA
XRCC5
ZEB1
ZNF821
123 interacting genes:
AATF
ANXA1
APTX
ATM
ATR
BCL2
BGLT3
BLID
BRD7
BUB3
CASP1
CASP3
CASP7
CASP8
CD86
CDKN1A
CEBPA
CENPA
CENPB
CTCF
CTSB
CTSG
DTX2
DUX4
E2F1
E4F1
EPB41L2
ERBB2
ERCC6
ERG
ETS1
FNDC3B
FOXO1
GTF2F1
GZMB
GZMM
H1-1
H1-2
H1-5
H2AC18
H2BC4
H3-4
H4C3
HDAC1
HDAC3
HECTD3
HIPK2
HMGN1
HMGN2
HMGN4
HOXB7
HPF1
HSPA2
IKBKG
IL24
KAT2B
KLF5
LIG3
LINC00624
LZTR1
MACROH2A1
MALAT1
MED14
MED6
MORC2
MTA3
MYBL2
NAT10
NCL
NCOA6
NEDD8
NFATC1
NFKB1
NPM1
NRF1
NUDT16
OGT
OVOL2
PARP2
PARP3
PCNA
PIAS4
POLA1
POLA2
POU2F1
PRKDC
RARA
RASL10B
RBM14
RELA
RNF10
RNF144A
RNF168
RNF4
RPS3A
RSPH1
RXRA
SENP1
SENP3
SMURF2
SP1
SREK1
SUMO2
SUPT16H
SWAP70
TCF3
TCF4
THRSP
TP53
TP53BP1
TRIP12
UBE2I
USP1
USP15
USP7
WEE2-AS1
WRN
XRCC1
XRCC5
XRCC6
ZBTB16
ZBTB9
ZNF423
Entrez ID
472
142
HPRD ID
06347
01435
Ensembl ID
ENSG00000149311
ENSG00000143799
Uniprot IDs
A0AAQ5BH18
Q13315
Q6P7P1
P09874
PDB IDs
5NP0
5NP1
6HKA
6K9K
6K9L
7NI4
7NI5
7NI6
7SIC
7SID
8OXM
8OXO
8OXP
8OXQ
1UK0
1UK1
1WOK
2COK
2CR9
2CS2
2DMJ
2JVN
2L30
2L31
2N8A
2RCW
2RD6
2RIQ
3GJW
3GN7
3L3L
3L3M
3OD8
3ODA
3ODC
3ODE
4AV1
4DQY
4GV7
4HHY
4HHZ
4L6S
4OPX
4OQA
4OQB
4PJT
4R5W
4R6E
4RV6
4UND
4UXB
4XHU
4ZZZ
5A00
5DS3
5HA9
5KPN
5KPO
5KPP
5KPQ
5WRQ
5WRY
5WRZ
5WS0
5WS1
5WTC
5XSR
5XST
5XSU
6BHV
6GHK
6M3I
6NRF
6NRG
6NRH
6NRI
6NRJ
6NTU
6VKK
6VKO
6VKQ
6XVW
7AAA
7AAB
7AAC
7AAD
7CMW
7KK2
7KK3
7KK4
7KK5
7KK6
7ONR
7ONS
7ONT
7S68
7S6H
7S6M
7S81
7SCY
7SCZ
8FYY
8FYZ
8FZ1
8G0H
8HE7
8HLR
8JNZ
8U4W
9BPY
9CKC
9DMC
9ETQ
9ETR
Enriched GO Terms of Interacting Partners
?
DNA Damage Response
Nucleoplasm
DNA Metabolic Process
Cellular Response To Stress
Nucleus
DNA Repair
Regulation Of Cell Cycle
Signal Transduction In Response To DNA Damage
Regulation Of Primary Metabolic Process
Double-strand Break Repair
Response To Ionizing Radiation
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle Process
DNA Damage Checkpoint Signaling
Response To Radiation
Response To Stress
Negative Regulation Of Cell Cycle
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Nucleic Acid Metabolic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle Phase Transition
Intracellular Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA Metabolic Process
DNA Recombination
Chromosome Organization
Chromosome, Telomeric Region
Regulation Of Cellular Response To Stress
Response To Gamma Radiation
Site Of Double-strand Break
Chromosome
Nucleobase-containing Compound Metabolic Process
Protein Localization To Site Of Double-strand Break
Mitotic DNA Integrity Checkpoint Signaling
Positive Regulation Of Metabolic Process
Protein Localization To Organelle
Enzyme Binding
Macromolecule Metabolic Process
Mitotic DNA Damage Checkpoint Signaling
Regulation Of Double-strand Break Repair
Chromatin Organization
Regulation Of DNA Repair
DNA Binding
Negative Regulation Of Mitotic Cell Cycle
Recombinational Repair
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Nucleus
DNA Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Chromatin Organization
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA Damage Response
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Chromatin Binding
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Chromatin Remodeling
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Metabolic Process
Macromolecule Metabolic Process
Chromosome
Protein Modification Process
Negative Regulation Of DNA Metabolic Process
DNA Repair
DNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Cycle
Chromatin
Cellular Response To Stress
Post-translational Protein Modification
Negative Regulation Of Biosynthetic Process
Transcription Cis-regulatory Region Binding
Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Nonhomologous End Joining
Double-strand Break Repair
Negative Regulation Of Cell Cycle
Protein Localization To Chromosome
Negative Regulation Of RNA Metabolic Process
Regulation Of Cell Cycle Process
Transcription Regulator Complex
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Tagcloud (Intersection)
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