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ATM and DCLRE1C
Number of citations of the paper that reports this interaction (PubMedID
15456891
)
65
Data Source:
HPRD
(in vitro, in vivo)
ATM
DCLRE1C
Description
ATM serine/threonine kinase
DNA cross-link repair 1C
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Peroxisome
Peroxisomal Matrix
Centrosome
Spindle
Cytosol
Cytoskeleton
Cytoplasmic Vesicle
Site Of Double-strand Break
Extrinsic Component Of Synaptic Vesicle Membrane
DNA Repair Complex
Nucleus
Nucleoplasm
Golgi Apparatus
Nonhomologous End Joining Complex
Molecular Function
Nucleotide Binding
DNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
1-phosphatidylinositol-3-kinase Activity
Transferase Activity
Histone H2AXS139 Kinase Activity
Identical Protein Binding
Protein-containing Complex Binding
Protein Serine Kinase Activity
Single-stranded DNA Endodeoxyribonuclease Activity
Damaged DNA Binding
Nuclease Activity
Endonuclease Activity
Exonuclease Activity
Protein Binding
5'-3' Exonuclease Activity
Hydrolase Activity
5'-3' DNA Exonuclease Activity
Biological Process
Autophagosome Assembly
DNA Damage Checkpoint Signaling
Pexophagy
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
Ovarian Follicle Development
Somitogenesis
Pre-B Cell Allelic Exclusion
Immune System Process
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Chromatin Remodeling
Protein Phosphorylation
Protein Monoubiquitination
DNA Damage Response
Response To Oxidative Stress
Mitotic Spindle Assembly Checkpoint Signaling
Mitotic G2 DNA Damage Checkpoint Signaling
Meiosis I
Reciprocal Meiotic Recombination
Male Meiotic Nuclear Division
Female Meiotic Nuclear Division
Signal Transduction
Female Gamete Generation
Brain Development
Heart Development
Determination Of Adult Lifespan
Female Gonad Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Post-embryonic Development
Response To Ionizing Radiation
Regulation Of Gene Expression
Regulation Of Autophagy
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
V(D)J Recombination
Cellular Response To Stress
Cellular Response To Reactive Oxygen Species
Multicellular Organism Growth
Phosphatidylinositol-3-phosphate Biosynthetic Process
Peptidyl-serine Autophosphorylation
Lipoprotein Catabolic Process
Response To Starvation
Signal Transduction In Response To DNA Damage
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Neuron Apoptotic Process
Meiotic Telomere Clustering
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
Thymus Development
Oocyte Development
Protein Stabilization
Neuron Apoptotic Process
Regulation Of Cell Cycle
Chromosome Organization Involved In Meiotic Cell Cycle
Protein K63-linked Ubiquitination
Histone MRNA Catabolic Process
Cellular Response To Retinoic Acid
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Cellular Response To Nitrosative Stress
Regulation Of Cellular Response To Stress
Cellular Senescence
Replicative Senescence
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of Cellular Response To Heat
Cellular Response To Oxygen-containing Compound
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of TORC1 Signaling
Negative Regulation Of Telomere Capping
Positive Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Protein Localization To Site Of Double-strand Break
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Double-strand Break Repair
Regulation Of Autophagosome Assembly
Positive Regulation Of Autophagosome Assembly
Telomere Maintenance
Adaptive Immune Response
Immune System Process
DNA Metabolic Process
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
DNA Damage Response
Response To Ionizing Radiation
B Cell Differentiation
V(D)J Recombination
Interstrand Cross-link Repair
Chromosome Organization
Pathways
DNA Damage/Telomere Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
Autodegradation of the E3 ubiquitin ligase COP1
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 Regulates Transcription of Caspase Activators and Caspases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
G2/M DNA damage checkpoint
Stabilization of p53
Meiotic recombination
Pexophagy
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Nonhomologous End-Joining (NHEJ)
Drugs
Caffeine
Diseases
Ataxia telangiectasia (AT); Louis-Bar syndrome; Boder-Sedgwick syndrome
Chronic lymphocytic leukemia (CLL)
Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS
Alzheimer's disease (late onset) (
28714976
)
Cutaneous malignant melanoma (
32341527
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of white cells (
27863252
32888494
)
Gastric adenocarcinoma (histologically verified) (
26098866
)
Gastric cancer (
26098866
)
Leukocyte telomere length (
32109421
31171785
)
Lymphocyte count (
32888494
)
Mean reticulocyte volume (
32888494
)
Melanoma (
21983787
28212542
)
Myeloproliferative neoplasms (
33057200
)
Nevus count or cutaneous melanoma (
30429480
32341527
)
Nonunion in individuals with fractures (
30680360
)
Prostate cancer (
29892016
)
Red blood cell count (
29403010
)
Refractive error (
32231278
)
Renal cell carcinoma (
28598434
)
Response to metformin in type 2 diabetes (glycemic) (
21186350
)
Rheumatoid arthritis (
30423114
24390342
)
Sum eosinophil basophil counts (
27863252
)
Uterine fibroids (
30194396
)
Lymphocyte count (
32888494
)
Response to cognitive-behavioural therapy in anxiety disorder (
31123309
)
Interacting Genes
135 interacting genes:
AATF
ABL1
ACTL6B
AP1B1
AP2B1
AP3B1
AP3B2
APBB1
ATR
BCAS3
BCL10
BRCA1
CDC6
CDKN2C
CDX2
CHD4
CHEK1
CHEK2
CHUK
COPS5
CREB1
CRX
CSNK1A1
CSNK1D
CTTN
CXXC5
CYREN
DAXX
DCAF1
DCK
DCLRE1C
DDX1
DYRK2
E2F1
E4F1
EEF1E1
EIF3E
EIF4EBP1
EP400
EPHA5
ERRFI1
ESRRG
EXO1
FANCD2
FECH
FUS
H1-2
H2AX
HIF1A
HMGA1
HSPA8
IL24
KAT5
KAT8
KPNA1
KPNA3
KPNA5
LCOR
LIG4
MAP1S
MAPK1
MAPK14
MAPK8
MCM2
MCPH1
MDC1
MDM2
MDM4
MRE11
MT-ND4
MTA3
MUC1
NBN
NFE2L2
NHEJ1
NPM1
NR4A1
NREP
NSD3
OSGIN1
PAN2
PARP1
PCNA
PEX5
PIDD1
POLL
POLR2A
PPP2R1A
PPP2R5C
PRKAA1
PRKDC
PTCH1
PTEN
RAD17
RAD50
RAD51
RAD9A
RANBP9
RASSF1
RBBP8
RHEB
RNF20
RNF40
RPA1
RPA2
RPS6KA1
RPS6KA3
SIN3A
SMARCA4
SMC1A
SPOP
SPSB1
STK11
TCL1A
TERF1
TERF2
TFF1
TIPARP
TOP1
TOP2A
TOPBP1
TP53
TP53BP1
TRAF6
TREX1
TRIM29
TTI1
UCHL3
USP37
VAC14
WRN
XPA
XRCC5
ZEB1
ZNF821
10 interacting genes:
ATM
ATR
BRCA1
CDKN1B
DDB2
MRE11
NBN
PRKDC
RAD50
TP53BP1
Entrez ID
472
64421
HPRD ID
06347
05817
Ensembl ID
ENSG00000149311
ENSG00000152457
Uniprot IDs
A0AAQ5BH18
Q13315
Q6P7P1
A0A8V8TKN9
A0A8V8TLX1
B3KMX5
Q96SD1
PDB IDs
5NP0
5NP1
6HKA
6K9K
6K9L
7NI4
7NI5
7NI6
7SIC
7SID
8OXM
8OXO
8OXP
8OXQ
3W1B
3W1G
4HTP
6TT5
6WNL
6WO0
7ABS
7AF1
7AFS
7AFU
7AGI
7APV
7SGL
7TYR
Enriched GO Terms of Interacting Partners
?
DNA Damage Response
Nucleoplasm
DNA Metabolic Process
Cellular Response To Stress
Nucleus
DNA Repair
Regulation Of Cell Cycle
Signal Transduction In Response To DNA Damage
Regulation Of Primary Metabolic Process
Double-strand Break Repair
Response To Ionizing Radiation
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle Process
DNA Damage Checkpoint Signaling
Response To Radiation
Response To Stress
Negative Regulation Of Cell Cycle
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Nucleic Acid Metabolic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle Phase Transition
Intracellular Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA Metabolic Process
DNA Recombination
Chromosome Organization
Chromosome, Telomeric Region
Regulation Of Cellular Response To Stress
Response To Gamma Radiation
Site Of Double-strand Break
Chromosome
Nucleobase-containing Compound Metabolic Process
Protein Localization To Site Of Double-strand Break
Mitotic DNA Integrity Checkpoint Signaling
Positive Regulation Of Metabolic Process
Protein Localization To Organelle
Enzyme Binding
Macromolecule Metabolic Process
Mitotic DNA Damage Checkpoint Signaling
Regulation Of Double-strand Break Repair
Chromatin Organization
Regulation Of DNA Repair
DNA Binding
Negative Regulation Of Mitotic Cell Cycle
Recombinational Repair
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Strand Resection Involved In Replication Fork Processing
Positive Regulation Of DNA Metabolic Process
Signal Transduction In Response To DNA Damage
Negative Regulation Of Cell Cycle
Negative Regulation Of Mitotic Cell Cycle
DNA Damage Checkpoint Signaling
Double-strand Break Repair
DNA Damage Response
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of DNA Repair
Regulation Of DNA Metabolic Process
Mitotic G2/M Transition Checkpoint
Negative Regulation Of Cell Cycle Process
DNA Repair
Regulation Of Double-strand Break Repair
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
BRCA1-C Complex
Negative Regulation Of Cell Cycle G2/M Phase Transition
Chromosome, Telomeric Region
DNA Metabolic Process
Regulation Of Cell Cycle Process
Telomere Maintenance
Homologous Recombination
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Regulation Of Mitotic Cell Cycle
Telomere Organization
Regulation Of Cellular Response To Stress
Cellular Response To Stress
Negative Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of DNA Repair
Recombinational Repair
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of Cell Cycle
Histone H2AXS139 Kinase Activity
Chromatin Remodeling
Mitotic DNA Damage Checkpoint Signaling
Chromosome
Mitotic DNA Integrity Checkpoint Signaling
Positive Regulation Of Telomere Maintenance
Chromosomal Region
Telomeric 3' Overhang Formation
DNA Double-strand Break Processing
Protein Localization To Site Of Double-strand Break
Chromatin Organization
Positive Regulation Of Double-strand Break Repair
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Tagcloud (Intersection)
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