ATM and TRAF6

Number of citations of the paper that reports this interaction (PubMedID 20932475)
0

Data Source:
BioGRID (pull down)

		ATM	TRAF6
Description		ATM serine/threonine kinase	TNF receptor associated factor 6
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Peroxisome Peroxisomal Matrix Centrosome Spindle Cytosol Cytoskeleton Cytoplasmic Vesicle Site Of Double-strand Break Extrinsic Component Of Synaptic Vesicle Membrane DNA Repair Complex	Nucleus Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Cortex Cytoplasmic Side Of Plasma Membrane Endosome Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex CD40 Receptor Complex Perinuclear Region Of Cytoplasm Glutamatergic Synapse
	Molecular Function	Nucleotide Binding DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity Histone H2AXS139 Kinase Activity Identical Protein Binding Protein-containing Complex Binding Protein Serine Kinase Activity	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein-macromolecule Adaptor Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin-ubiquitin Ligase Activity Signaling Adaptor Activity Identical Protein Binding Histone Deacetylase Binding Protein Kinase B Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Autophagosome Assembly DNA Damage Checkpoint Signaling Pexophagy Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Ovarian Follicle Development Somitogenesis Pre-B Cell Allelic Exclusion Immune System Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Remodeling Protein Phosphorylation Protein Monoubiquitination DNA Damage Response Response To Oxidative Stress Mitotic Spindle Assembly Checkpoint Signaling Mitotic G2 DNA Damage Checkpoint Signaling Meiosis I Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiotic Nuclear Division Signal Transduction Female Gamete Generation Brain Development Heart Development Determination Of Adult Lifespan Female Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Post-embryonic Development Response To Ionizing Radiation Regulation Of Gene Expression Regulation Of Autophagy Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase V(D)J Recombination Cellular Response To Stress Cellular Response To Reactive Oxygen Species Multicellular Organism Growth Phosphatidylinositol-3-phosphate Biosynthetic Process Peptidyl-serine Autophosphorylation Lipoprotein Catabolic Process Response To Starvation Signal Transduction In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neuron Apoptotic Process Meiotic Telomere Clustering Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Thymus Development Oocyte Development Protein Stabilization Neuron Apoptotic Process Regulation Of Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Protein K63-linked Ubiquitination Histone MRNA Catabolic Process Cellular Response To Retinoic Acid Cellular Response To Gamma Radiation Cellular Response To X-ray Cellular Response To Nitrosative Stress Regulation Of Cellular Response To Stress Cellular Senescence Replicative Senescence Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA Strand Resection Involved In Replication Fork Processing Regulation Of Cellular Response To Heat Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling Negative Regulation Of Telomere Capping Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomerase Catalytic Core Complex Assembly Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Regulation Of Autophagosome Assembly Positive Regulation Of Autophagosome Assembly	Autophagosome Assembly Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ossification In Utero Embryonic Development Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Immune System Process Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response DNA Damage Response Signal Transduction Canonical NF-kappaB Signal Transduction MRNA Transcription Animal Organ Morphogenesis Protein Ubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II CD40 Signaling Pathway Osteoclast Differentiation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Fc-epsilon Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Interleukin-17A-mediated Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Defense Response To Bacterium Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Bone Resorption Positive Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Bone Remodeling Cell Development T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Response To Interleukin-1 Protein K48-linked Ubiquitination Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Interleukin-17-mediated Signaling Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Antiviral Innate Immune Response Intracellular Signaling Cassette Protein Branched Polyubiquitination Cellular Response To Oxygen-containing Compound Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		DNA Damage/Telomere Stress Induced Senescence Regulation of HSF1-mediated heat shock response Autodegradation of the E3 ubiquitin ligase COP1 HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Caspase Activators and Caspases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Meiotic recombination Pexophagy Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Regulated proteolysis of p75NTR Downstream TCR signaling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Ub-specific processing proteases Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling MyD88 cascade initiated on plasma membrane
Drugs		Caffeine
Diseases		Ataxia telangiectasia (AT); Louis-Bar syndrome; Boder-Sedgwick syndrome Chronic lymphocytic leukemia (CLL) Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Alzheimer's disease (late onset) ( 28714976) Cutaneous malignant melanoma ( 32341527) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) Gastric adenocarcinoma (histologically verified) ( 26098866) Gastric cancer ( 26098866) Leukocyte telomere length ( 32109421 31171785) Lymphocyte count ( 32888494) Mean reticulocyte volume ( 32888494) Melanoma ( 21983787 28212542) Myeloproliferative neoplasms ( 33057200) Nevus count or cutaneous melanoma ( 30429480 32341527) Nonunion in individuals with fractures ( 30680360) Prostate cancer ( 29892016) Red blood cell count ( 29403010) Refractive error ( 32231278) Renal cell carcinoma ( 28598434) Response to metformin in type 2 diabetes (glycemic) ( 21186350) Rheumatoid arthritis ( 30423114 24390342) Sum eosinophil basophil counts ( 27863252) Uterine fibroids ( 30194396)	Idiopathic inflammatory myopathy ( 26362759) Metabolite levels ( 23823483) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		135 interacting genes: AATF ABL1 ACTL6B AP1B1 AP2B1 AP3B1 AP3B2 APBB1 ATR BCAS3 BCL10 BRCA1 CDC6 CDKN2C CDX2 CHD4 CHEK1 CHEK2 CHUK COPS5 CREB1 CRX CSNK1A1 CSNK1D CTTN CXXC5 CYREN DAXX DCAF1 DCK DCLRE1C DDX1 DYRK2 E2F1 E4F1 EEF1E1 EIF3E EIF4EBP1 EP400 EPHA5 ERRFI1 ESRRG EXO1 FANCD2 FECH FUS H1-2 H2AX HIF1A HMGA1 HSPA8 IL24 KAT5 KAT8 KPNA1 KPNA3 KPNA5 LCOR LIG4 MAP1S MAPK1 MAPK14 MAPK8 MCM2 MCPH1 MDC1 MDM2 MDM4 MRE11 MT-ND4 MTA3 MUC1 NBN NFE2L2 NHEJ1 NPM1 NR4A1 NREP NSD3 OSGIN1 PAN2 PARP1 PCNA PEX5 PIDD1 POLL POLR2A PPP2R1A PPP2R5C PRKAA1 PRKDC PTCH1 PTEN RAD17 RAD50 RAD51 RAD9A RANBP9 RASSF1 RBBP8 RHEB RNF20 RNF40 RPA1 RPA2 RPS6KA1 RPS6KA3 SIN3A SMARCA4 SMC1A SPOP SPSB1 STK11 TCL1A TERF1 TERF2 TFF1 TIPARP TOP1 TOP2A TOPBP1 TP53 TP53BP1 TRAF6 TREX1 TRIM29 TTI1 UCHL3 USP37 VAC14 WRN XPA XRCC5 ZEB1 ZNF821	184 interacting genes: ABL1 AKT1 APP ATM ATP6V1E1 ATXN3 BANK1 BCL3 BEX3 BMPR1B BRSK2 CAV1 CBL CD40 CUL5 CYLD DLG4 DNA2 ECSIT EDA2R EDARADD FADD FAM177A1 FHL2 FYN GART GTF2I H2AX H2BC21 HNRNPA1 HSD17B10 HSPA4 IL17RB IPMK IQUB IRAK1 IRAK2 IRAK3 IRAK4 IRF5 IRF7 IRF8 JAK2 KCNQ1 LIMD1 LNX1 MALT1 MAP2K1 MAP2K6 MAP2K7 MAP3K11 MAP3K14 MAP3K3 MAP3K5 MAP3K7 MAP3K8 MAPK14 MAPK8 MAPT MAST2 MATR3 MAVS MBP MCL1 MEOX2 MTOR MTURN NEAT1 NGFR NOL3 NTRK1 NTRK2 NUMBL OTUB1 OTUB2 OTUD7B PEDS1-UBE2V1 PELI3 PFN1 PHLDA1 PINK1 PLEKHF2 PLEKHO1 POLI PPP4C PRKCZ PSMB5 PSMC1 PSMC2 PSMC3 PSMD1 PSMD12 PSMD13 PSMD6 PSMD7 PTPN6 RAD23A RIPK1 RIPK2 RIPK3 RNF114 RNF152 RNF31 RPL3 RPS2 RPS20 RPS27A RSAD2 SIGIRR SPHK1 SPOP SQSTM1 SRC STAMBP STK17A STK26 STRADB STUB1 SUFU SYK TAB1 TAB2 TAB3 TANK TAX1BP1 TDP2 TGFBR1 TICAM1 TICAM2 TIFA TIRAP TLR3 TNFAIP3 TNFRSF11A TNFRSF13B TNFRSF19 TNFSF11 TRAF1 TRAF2 TRAF3IP1 TRAF3IP2 TRAF4 TRAF5 TRAF7 TRAFD1 TRAM1 TRIM17 TRIM25 TRIM37 TTC3 TXNIP UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L3 UBE2N UBE2V1 UBOX5 UBTD1 UBXN7 UEVLD USP1 USP15 USP2 USP21 USP39 USP7 VPS52 XIAP YBX1 YES1 YOD1 YWHAQ ZBTB25 ZDHHC11 ZFAND5 ZMYND11 ZNF675 ZRANB1
Entrez ID		472	7189
HPRD ID		06347	03833
Ensembl ID		ENSG00000149311	ENSG00000175104
Uniprot IDs		A0AAQ5BH18 Q13315 Q6P7P1	Q9Y4K3
PDB IDs		5NP0 5NP1 6HKA 6K9K 6K9L 7NI4 7NI5 7NI6 7SIC 7SID 8OXM 8OXO 8OXP 8OXQ	1LB4 1LB5 1LB6 2ECI 2JMD 3HCS 3HCT 3HCU 4Z8M 5ZUJ 6A33 7L3L 8HZ2
Enriched GO Terms of Interacting Partners?		DNA Damage Response Nucleoplasm DNA Metabolic Process Cellular Response To Stress Nucleus DNA Repair Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of Primary Metabolic Process Double-strand Break Repair Response To Ionizing Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process DNA Damage Checkpoint Signaling Response To Radiation Response To Stress Negative Regulation Of Cell Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Nucleic Acid Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process DNA Recombination Chromosome Organization Chromosome, Telomeric Region Regulation Of Cellular Response To Stress Response To Gamma Radiation Site Of Double-strand Break Chromosome Nucleobase-containing Compound Metabolic Process Protein Localization To Site Of Double-strand Break Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Metabolic Process Protein Localization To Organelle Enzyme Binding Macromolecule Metabolic Process Mitotic DNA Damage Checkpoint Signaling Regulation Of Double-strand Break Repair Chromatin Organization Regulation Of DNA Repair DNA Binding Negative Regulation Of Mitotic Cell Cycle Recombinational Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process	Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Protein Modification Process Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Post-translational Protein Modification Regulation Of Signaling Regulation Of Cell Communication Innate Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Response To Stress Immune Response-regulating Signaling Pathway Regulation Of Defense Response Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Innate Immune Response Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Proteolysis Cytosol Activation Of Immune Response Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Polyubiquitination Positive Regulation Of Immune Response Regulation Of Innate Immune Response Macromolecule Metabolic Process Regulation Of Immune Response Defense Response Protein Kinase Activity MAPK Cascade Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Transferase Activity Negative Regulation Of Signal Transduction Regulation Of Cytokine-mediated Signaling Pathway Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Signaling
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?