ATM and TOPBP1

Number of citations: 73 (PubMedID 11756551)
Data Source: BioGRID (enzymatic study, affinity chromatography technology), HPRD (in vitro, in vivo)

		ATM	TOPBP1
Name		ATM serine/threonine kinase	DNA topoisomerase II binding protein 1
Structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Peroxisome Peroxisomal Matrix Centrosome Spindle Cytosol Cytoskeleton Cytoplasmic Vesicle Site Of Double-strand Break Extrinsic Component Of Synaptic Vesicle Membrane DNA Repair Complex	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Site Of Double-strand Break BRCA1-B Complex Site Of DNA Damage
	Molecular Function	Nucleotide Binding DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity Histone H2AXS139 Kinase Activity Identical Protein Binding Protein-containing Complex Binding Protein Serine Kinase Activity	DNA Binding Protein Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Phosphorylation-dependent Protein Binding Chromatin-protein Adaptor Activity
	Biological Process	Autophagosome Assembly DNA Damage Checkpoint Signaling Pexophagy Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Ovarian Follicle Development Somitogenesis Pre-B Cell Allelic Exclusion Immune System Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Remodeling Protein Phosphorylation Protein Monoubiquitination DNA Damage Response Response To Oxidative Stress Mitotic Spindle Assembly Checkpoint Signaling Mitotic G2 DNA Damage Checkpoint Signaling Meiosis I Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiotic Nuclear Division Signal Transduction Female Gamete Generation Brain Development Heart Development Determination Of Adult Lifespan Female Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Post-embryonic Development Response To Ionizing Radiation Regulation Of Gene Expression Regulation Of Autophagy Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase V(D)J Recombination Cellular Response To Stress Cellular Response To Reactive Oxygen Species Multicellular Organism Growth Phosphatidylinositol-3-phosphate Biosynthetic Process Peptidyl-serine Autophosphorylation Lipoprotein Catabolic Process Response To Starvation Signal Transduction In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neuron Apoptotic Process Meiotic Telomere Clustering Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Thymus Development Oocyte Development Protein Stabilization Neuron Apoptotic Process Regulation Of Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Protein K63-linked Ubiquitination Histone MRNA Catabolic Process Cellular Response To Retinoic Acid Cellular Response To Gamma Radiation Cellular Response To X-ray Cellular Response To Nitrosative Stress Regulation Of Cellular Response To Stress Cellular Senescence Replicative Senescence Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA Strand Resection Involved In Replication Fork Processing Regulation Of Cellular Response To Heat Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling Negative Regulation Of Telomere Capping Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomerase Catalytic Core Complex Assembly Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Regulation Of Autophagosome Assembly Positive Regulation Of Autophagosome Assembly	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication Initiation DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Signaling Homologous Recombination Chromosome Organization Double-strand Break Repair Via Classical Nonhomologous End Joining Double-strand Break Repair Via Alternative Nonhomologous End Joining Broken Chromosome Clustering Protein Localization To Site Of Double-strand Break
Pathways		DNA Damage/Telomere Stress Induced Senescence Regulation of HSF1-mediated heat shock response Autodegradation of the E3 ubiquitin ligase COP1 HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Caspase Activators and Caspases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Meiotic recombination Pexophagy Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs		Caffeine	None
Diseases		Ataxia telangiectasia (AT); Louis-Bar syndrome; Boder-Sedgwick syndrome Chronic lymphocytic leukemia (CLL) Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome	None
GWAS		Alzheimer's disease (late onset) ( 28714976 ) Cutaneous malignant melanoma ( 32341527 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Gastric adenocarcinoma (histologically verified) ( 26098866 ) Gastric cancer ( 26098866 ) Leukocyte telomere length ( 32109421 31171785 ) Lymphocyte count ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Melanoma ( 21983787 28212542 ) Myeloproliferative neoplasms ( 33057200 ) Nevus count or cutaneous melanoma ( 30429480 32341527 ) Nonunion in individuals with fractures ( 30680360 ) Prostate cancer ( 29892016 ) Red blood cell count ( 29403010 ) Refractive error ( 32231278 ) Renal cell carcinoma ( 28598434 ) Response to metformin in type 2 diabetes (glycemic) ( 21186350 ) Rheumatoid arthritis ( 30423114 24390342 ) Sum eosinophil basophil counts ( 27863252 ) Uterine fibroids ( 30194396 )	Iron status biomarkers ( 19084217 )
Novel Interactors		9 novel interactors: ARHGAP20 BCO2 CD9 CRYAB HINT1 HSPB2 PGR POLR2F PTS	1 novel interactors: NPHP3
Interacting Genes		135 interacting genes: AATF ABL1 ACTL6B AP1B1 AP2B1 AP3B1 AP3B2 APBB1 ATR BCAS3 BCL10 BRCA1 CDC6 CDKN2C CDX2 CHD4 CHEK1 CHEK2 CHUK COPS5 CREB1 CRX CSNK1A1 CSNK1D CTTN CXXC5 CYREN DAXX DCAF1 DCK DCLRE1C DDX1 DYRK2 E2F1 E4F1 EEF1E1 EIF3E EIF4EBP1 EP400 EPHA5 ERRFI1 ESRRG EXO1 FANCD2 FECH FUS H1-2 H2AX HIF1A HMGA1 HSPA8 IL24 KAT5 KAT8 KPNA1 KPNA3 KPNA5 LCOR LIG4 MAP1S MAPK1 MAPK14 MAPK8 MCM2 MCPH1 MDC1 MDM2 MDM4 MRE11 MT-ND4 MTA3 MUC1 NBN NFE2L2 NHEJ1 NPM1 NR4A1 NREP NSD3 OSGIN1 PAN2 PARP1 PCNA PEX5 PIDD1 POLL POLR2A PPP2R1A PPP2R5C PRKAA1 PRKDC PTCH1 PTEN RAD17 RAD50 RAD51 RAD9A RANBP9 RASSF1 RBBP8 RHEB RNF20 RNF40 RPA1 RPA2 RPS6KA1 RPS6KA3 SIN3A SMARCA4 SMC1A SPOP SPSB1 STK11 TCL1A TERF1 TERF2 TFF1 TIPARP TOP1 TOP2A TOPBP1 TP53 TP53BP1 TRAF6 TREX1 TRIM29 TTI1 UCHL3 USP37 VAC14 WRN XPA XRCC5 ZEB1 ZNF821	30 interacting genes: ABL1 AKT1 ATM BMPR2 BRIP1 CDC45 CHEK1 CIP2A CLSTN1 E2F1 ESR1 GINS1 HUS1 NFYA PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 SMARCAD1 TBC1D4 TCFL5 TEX11 TOP2B UBR5 USP13 ZBTB17
Entrez ID		472	11073
HPRD ID		06347	09678
Ensembl ID		ENSG00000149311	ENSG00000163781
Uniprot IDs		A0AAQ5BH18 Q13315 Q6P7P1	A0A2R8YD63 A0AV47 A7E2X7 Q05BV8 Q92547
PDB IDs		5NP0 5NP1 6HKA 6K9K 6K9L 7NI4 7NI5 7NI6 7SIC 7SID 8OXM 8OXO 8OXP 8OXQ	1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM 7CMZ 8OK2
GO Terms Enriched among Interactors		DNA Damage Response Nucleoplasm DNA Metabolic Process Cellular Response To Stress Nucleus DNA Repair Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of Primary Metabolic Process Double-strand Break Repair Response To Ionizing Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process DNA Damage Checkpoint Signaling Response To Radiation Response To Stress Negative Regulation Of Cell Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Nucleic Acid Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process DNA Recombination Chromosome Organization Chromosome, Telomeric Region Regulation Of Cellular Response To Stress Response To Gamma Radiation Site Of Double-strand Break Chromosome Nucleobase-containing Compound Metabolic Process Protein Localization To Site Of Double-strand Break Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Metabolic Process Protein Localization To Organelle Enzyme Binding Macromolecule Metabolic Process Mitotic DNA Damage Checkpoint Signaling Regulation Of Double-strand Break Repair Chromatin Organization Regulation Of DNA Repair DNA Binding Negative Regulation Of Mitotic Cell Cycle Recombinational Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process	DNA Metabolic Process Negative Regulation Of Cell Cycle DNA Damage Response Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Cellular Response To Stress Nucleoplasm DNA Repair Negative Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Chromosome Macromolecule Metabolic Process Checkpoint Clamp Complex Negative Regulation Of Mitotic Cell Cycle DNA Double-strand Break Processing Intracellular Signal Transduction Nucleus Chromosome Organization Regulation Of Mitotic Cell Cycle Reproductive Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cell Cycle Process Homologous Recombination Response To Stress Mitotic G2/M Transition Checkpoint Positive Regulation Of Fibroblast Proliferation Regulation Of Cellular Response To Stress DNA Recombination Cellular Senescence DNA Replication Checkpoint Signaling Regulation Of RNA Biosynthetic Process Response To Ionizing Radiation Regulation Of Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Cellular Response To Ionizing Radiation Response To Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Developmental Process Involved In Reproduction Regulation Of RNA Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of DNA Metabolic Process