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ATM and DDX1
Number of citations of the paper that reports this interaction (PubMedID
18710941
)
63
Data Source:
BioGRID
(affinity chromatography technology, pull down)
ATM
DDX1
Description
ATM serine/threonine kinase
DEAD-box helicase 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Peroxisome
Peroxisomal Matrix
Centrosome
Spindle
Cytosol
Cytoskeleton
Cytoplasmic Vesicle
Site Of Double-strand Break
Extrinsic Component Of Synaptic Vesicle Membrane
DNA Repair Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Cytoplasmic Stress Granule
Membrane
Cleavage Body
TRNA-splicing Ligase Complex
Ribonucleoprotein Complex
Molecular Function
Nucleotide Binding
DNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
1-phosphatidylinositol-3-kinase Activity
Transferase Activity
Histone H2AXS139 Kinase Activity
Identical Protein Binding
Protein-containing Complex Binding
Protein Serine Kinase Activity
Nucleotide Binding
Nucleic Acid Binding
DNA Binding
Chromatin Binding
Transcription Coregulator Activity
RNA Binding
RNA Helicase Activity
Double-stranded RNA Binding
Helicase Activity
Nuclease Activity
Exonuclease Activity
Protein Binding
ATP Binding
Poly(A) Binding
Hydrolase Activity
ATP Hydrolysis Activity
DNA/RNA Helicase Activity
Biological Process
Autophagosome Assembly
DNA Damage Checkpoint Signaling
Pexophagy
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
Ovarian Follicle Development
Somitogenesis
Pre-B Cell Allelic Exclusion
Immune System Process
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Chromatin Remodeling
Protein Phosphorylation
Protein Monoubiquitination
DNA Damage Response
Response To Oxidative Stress
Mitotic Spindle Assembly Checkpoint Signaling
Mitotic G2 DNA Damage Checkpoint Signaling
Meiosis I
Reciprocal Meiotic Recombination
Male Meiotic Nuclear Division
Female Meiotic Nuclear Division
Signal Transduction
Female Gamete Generation
Brain Development
Heart Development
Determination Of Adult Lifespan
Female Gonad Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Post-embryonic Development
Response To Ionizing Radiation
Regulation Of Gene Expression
Regulation Of Autophagy
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
V(D)J Recombination
Cellular Response To Stress
Cellular Response To Reactive Oxygen Species
Multicellular Organism Growth
Phosphatidylinositol-3-phosphate Biosynthetic Process
Peptidyl-serine Autophosphorylation
Lipoprotein Catabolic Process
Response To Starvation
Signal Transduction In Response To DNA Damage
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Neuron Apoptotic Process
Meiotic Telomere Clustering
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
Thymus Development
Oocyte Development
Protein Stabilization
Neuron Apoptotic Process
Regulation Of Cell Cycle
Chromosome Organization Involved In Meiotic Cell Cycle
Protein K63-linked Ubiquitination
Histone MRNA Catabolic Process
Cellular Response To Retinoic Acid
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Cellular Response To Nitrosative Stress
Regulation Of Cellular Response To Stress
Cellular Senescence
Replicative Senescence
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of Cellular Response To Heat
Cellular Response To Oxygen-containing Compound
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of TORC1 Signaling
Negative Regulation Of Telomere Capping
Positive Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Protein Localization To Site Of Double-strand Break
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Double-strand Break Repair
Regulation Of Autophagosome Assembly
Positive Regulation Of Autophagosome Assembly
Spliceosomal Complex Assembly
Immune System Process
Positive Regulation Of Myeloid Dendritic Cell Cytokine Production
Double-strand Break Repair
TRNA Splicing, Via Endonucleolytic Cleavage And Ligation
MRNA Processing
Regulation Of Translational Initiation
TRNA Processing
Response To Virus
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Exogenous DsRNA
Innate Immune Response
Defense Response To Virus
Protein Localization To Cytoplasmic Stress Granule
Pathways
DNA Damage/Telomere Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
Autodegradation of the E3 ubiquitin ligase COP1
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 Regulates Transcription of Caspase Activators and Caspases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
G2/M DNA damage checkpoint
Stabilization of p53
Meiotic recombination
Pexophagy
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
tRNA processing in the nucleus
Drugs
Caffeine
Diseases
Ataxia telangiectasia (AT); Louis-Bar syndrome; Boder-Sedgwick syndrome
Chronic lymphocytic leukemia (CLL)
Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Alzheimer's disease (late onset) (
28714976
)
Cutaneous malignant melanoma (
32341527
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of white cells (
27863252
32888494
)
Gastric adenocarcinoma (histologically verified) (
26098866
)
Gastric cancer (
26098866
)
Leukocyte telomere length (
32109421
31171785
)
Lymphocyte count (
32888494
)
Mean reticulocyte volume (
32888494
)
Melanoma (
21983787
28212542
)
Myeloproliferative neoplasms (
33057200
)
Nevus count or cutaneous melanoma (
30429480
32341527
)
Nonunion in individuals with fractures (
30680360
)
Prostate cancer (
29892016
)
Red blood cell count (
29403010
)
Refractive error (
32231278
)
Renal cell carcinoma (
28598434
)
Response to metformin in type 2 diabetes (glycemic) (
21186350
)
Rheumatoid arthritis (
30423114
24390342
)
Sum eosinophil basophil counts (
27863252
)
Uterine fibroids (
30194396
)
Asthma or chronic obstructive pulmonary disease (
24993907
)
Blood urea nitrogen levels (
31152163
)
Chronic kidney disease (
22479191
)
Chronic obstructive pulmonary disease (
30804561
)
Estimated glomerular filtration rate (
30604766
31451708
31152163
31015462
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Kidney volume (
34128465
)
Metabolite levels (
23823483
)
Pulmonary function (
21946350
)
Pulmonary function (smoking interaction) (
23284291
)
Severe COVID-19 infection with respiratory failure (analysis I) (
32558485
)
Urate levels (
31578528
)
Wilms tumor (
22544364
)
Interacting Genes
135 interacting genes:
AATF
ABL1
ACTL6B
AP1B1
AP2B1
AP3B1
AP3B2
APBB1
ATR
BCAS3
BCL10
BRCA1
CDC6
CDKN2C
CDX2
CHD4
CHEK1
CHEK2
CHUK
COPS5
CREB1
CRX
CSNK1A1
CSNK1D
CTTN
CXXC5
CYREN
DAXX
DCAF1
DCK
DCLRE1C
DDX1
DYRK2
E2F1
E4F1
EEF1E1
EIF3E
EIF4EBP1
EP400
EPHA5
ERRFI1
ESRRG
EXO1
FANCD2
FECH
FUS
H1-2
H2AX
HIF1A
HMGA1
HSPA8
IL24
KAT5
KAT8
KPNA1
KPNA3
KPNA5
LCOR
LIG4
MAP1S
MAPK1
MAPK14
MAPK8
MCM2
MCPH1
MDC1
MDM2
MDM4
MRE11
MT-ND4
MTA3
MUC1
NBN
NFE2L2
NHEJ1
NPM1
NR4A1
NREP
NSD3
OSGIN1
PAN2
PARP1
PCNA
PEX5
PIDD1
POLL
POLR2A
PPP2R1A
PPP2R5C
PRKAA1
PRKDC
PTCH1
PTEN
RAD17
RAD50
RAD51
RAD9A
RANBP9
RASSF1
RBBP8
RHEB
RNF20
RNF40
RPA1
RPA2
RPS6KA1
RPS6KA3
SIN3A
SMARCA4
SMC1A
SPOP
SPSB1
STK11
TCL1A
TERF1
TERF2
TFF1
TIPARP
TOP1
TOP2A
TOPBP1
TP53
TP53BP1
TRAF6
TREX1
TRIM29
TTI1
UCHL3
USP37
VAC14
WRN
XPA
XRCC5
ZEB1
ZNF821
88 interacting genes:
APP
ATM
CEBPA
CSTF2
EIF4ENIF1
ESR1
HNRNPK
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NDRG1
NME7
PTEN
RELA
RNF10
SNCA
SUMO2
WEE2-AS1
YWHAQ
Entrez ID
472
1653
HPRD ID
06347
03158
Ensembl ID
ENSG00000149311
ENSG00000079785
Uniprot IDs
A0AAQ5BH18
Q13315
Q6P7P1
A3RJH1
Q92499
PDB IDs
5NP0
5NP1
6HKA
6K9K
6K9L
7NI4
7NI5
7NI6
7SIC
7SID
8OXM
8OXO
8OXP
8OXQ
4XW3
8TBX
Enriched GO Terms of Interacting Partners
?
DNA Damage Response
Nucleoplasm
DNA Metabolic Process
Cellular Response To Stress
Nucleus
DNA Repair
Regulation Of Cell Cycle
Signal Transduction In Response To DNA Damage
Regulation Of Primary Metabolic Process
Double-strand Break Repair
Response To Ionizing Radiation
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle Process
DNA Damage Checkpoint Signaling
Response To Radiation
Response To Stress
Negative Regulation Of Cell Cycle
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Nucleic Acid Metabolic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle Phase Transition
Intracellular Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA Metabolic Process
DNA Recombination
Chromosome Organization
Chromosome, Telomeric Region
Regulation Of Cellular Response To Stress
Response To Gamma Radiation
Site Of Double-strand Break
Chromosome
Nucleobase-containing Compound Metabolic Process
Protein Localization To Site Of Double-strand Break
Mitotic DNA Integrity Checkpoint Signaling
Positive Regulation Of Metabolic Process
Protein Localization To Organelle
Enzyme Binding
Macromolecule Metabolic Process
Mitotic DNA Damage Checkpoint Signaling
Regulation Of Double-strand Break Repair
Chromatin Organization
Regulation Of DNA Repair
DNA Binding
Negative Regulation Of Mitotic Cell Cycle
Recombinational Repair
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
MiRNA-mediated Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
RISC Complex
Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
MRNA 3'-UTR Binding
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Extracellular Vesicle
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Translation
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of MRNA Catabolic Process
MRNA Destabilization
RNA Destabilization
Negative Regulation Of Cell Migration
Negative Regulation Of Angiogenesis
Negative Regulation Of Vasculature Development
Negative Regulation Of Cytokine Production
Regulation Of Metabolic Process
Negative Regulation Of Cell Motility
Positive Regulation Of MRNA Metabolic Process
Negative Regulation Of Multicellular Organismal Process
Regulation Of Angiogenesis
Negative Regulation Of Locomotion
Regulation Of Vasculature Development
Negative Regulation Of Vascular Endothelial Growth Factor Production
Negative Regulation Of Developmental Process
Regulation Of Translation
Regulation Of MRNA Stability
Negative Regulation Of Protein Metabolic Process
Regulation Of RNA Stability
Negative Regulation Of Signal Transduction
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Cell Migration
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Locomotion
Extracellular Space
Regulation Of Cell Motility
Positive Regulation Of Catabolic Process
Regulation Of MRNA Metabolic Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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