MBD4 and NAT2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MBD4	NAT2
Name		methyl-CpG binding domain 4, DNA glycosylase	N-acetyltransferase 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Cytoplasm Cytosol
	Molecular Function	DNA Binding Satellite DNA Binding Catalytic Activity DNA Endonuclease Activity Protein Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity Hydrolase Activity DNA N-glycosylase Activity	Arylamine N-acetyltransferase Activity Protein Binding Acetyltransferase Activity Transferase Activity Acyltransferase Activity N-hydroxyarylamine O-acetyltransferase Activity
	Biological Process	DNA Repair DNA Damage Response Response To Estradiol Depyrimidination	Xenobiotic Metabolic Process
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1	Acetylation Paracetamol ADME
GWAS		Diisocyanate-induced asthma ( 25918132 ) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Bladder cancer ( 20972438 24163127 ) Cholesterol, total ( 20686565 24097068 ) Coronary artery disease ( 29212778 33020668 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Insulin resistance/response ( 25798622 ) Iron status biomarkers (total iron binding capacity) ( 33536631 ) Iron status biomarkers (transferrin levels) ( 25352340 ) LDL cholesterol levels ( 32203549 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Liver injury in anti-tuberculosis drug treatment ( 31109976 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolic syndrome ( 31589552 ) Metabolic traits ( 21886157 ) Metabolite levels ( 23823483 ) Myocardial infarction ( 33532862 ) Night sleep phenotypes ( 27126917 ) Paclitaxel-induced neuropathy ( 23776197 ) Serum metabolite levels ( 33031748 ) Total cholesterol levels ( 28334899 33339817 ) Triglyceride levels ( 29403010 32203549 33339817 30698716 28334899 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 24097068 20686565 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 ) Urinary metabolites ( 26352407 21572414 ) Urinary metabolites (H-NMR features) ( 24586186 ) Youthful appearance (self-reported) ( 32339537 )
Novel Interactors		1 novel interactors: EPHB1	1 novel interactors: CLU
Interacting Genes		18 interacting genes: APP CDCA2 CSNK2B DNMT3B FADD FAS HDAC1 KDM1A MLH1 NAT2 RSPH1 SIN3A SUV39H1 TRIM27 TRIM55 TRIM63 UBE2I UHRF1	17 interacting genes: APC APP AURKA BAG4 CDKN2A CDKN2C ERBB2 FZR1 HMMR IGF1R MBD4 NAA10 NBN PALB2 PPM1D STK11 WT1
Entrez ID		8930	10
HPRD ID		04654	02000
Ensembl ID		ENSG00000129071	ENSG00000156006
Uniprot IDs		O95243	A4Z6T7 A9X7Q9 P11245
PDB IDs		2MOE 3IHO 4DK9 4E9E 4E9F 4E9G 4E9H 4EA4 4EA5 4LG7 4OFA 4OFE 4OFH 5CHZ 6VJW 7KZ0 7KZ1 7KZG	2PFR
GO Terms Enriched among Interactors		Epigenetic Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process CD95 Death-inducing Signaling Complex Heterochromatin Formation Death-inducing Signaling Complex Protein Modification Process Heterochromatin Condensed Nuclear Chromosome Transferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Necroptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme Binding Chromosome Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Motor Neuron Apoptotic Process Negative Regulation Of Gene Expression Cellular Response To Catecholamine Stimulus Response To Catecholamine SUMO Transferase Activity Positive Regulation Of Multicellular Organismal Process PML Body Nucleus Sin3-type Complex Macromolecule Metabolic Process Synaptonemal Complex Identical Protein Binding Negative Regulation Of Stem Cell Population Maintenance Regulation Of Primary Metabolic Process Positive Regulation Of Developmental Process Protein Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Neuron Maturation Immune System Process	Regulation Of Cellular Component Organization Negative Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Catabolic Process Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition Cell Population Proliferation Regulation Of Cell Cycle Process Positive Regulation Of Cellular Component Organization DNA Damage Response Response To Stress Nucleus Regulation Of Protein Metabolic Process Cytosol Positive Regulation Of Amyloid Fibril Formation Negative Regulation Of Immature T Cell Proliferation In Thymus Protein Modification Process Positive Regulation Of Catabolic Process Negative Regulation Of Immature T Cell Proliferation Negative Regulation Of Apoptotic Process Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Growth Negative Regulation Of Cell Cycle Negative Regulation Of Cell Growth Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Metabolic Process Developmental Growth Regulation Of Proteolysis Protein Localization To Organelle Regulation Of Reproductive Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of T Cell Differentiation In Thymus Regulation Of Cell Growth Positive Regulation Of Proteolysis Negative Regulation Of Cyclin-dependent Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Growth Negative Regulation Of Chromosome Organization Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity