MBD4 and CDCA2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MBD4	CDCA2
Gene Name		methyl-CpG binding domain protein 4	cell division cycle associated 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Nucleoplasm Chromosome Cytoplasm
	Molecular Function	Satellite DNA Binding Endodeoxyribonuclease Activity Protein Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity
	Biological Process	DNA Catabolic Process, Endonucleolytic DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Mitotic G2 DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Radiation Depyrimidination	Chromosome Segregation Mitotic Nuclear Division Positive Regulation Of Protein Dephosphorylation Cell Division
Pathways		Base Excision Repair Depyrimidination Resolution of AP sites via the multiple-nucleotide patch replacement pathway Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected pyrimidine Removal of DNA patch containing abasic residue Base-Excision Repair, AP Site Formation Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Displacement of DNA glycosylase by APE1 Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CDCA2 CSNK2B DNMT3B FADD FAS HDAC1 KDM1A MLH1 SIN3A SUV39H1 TRIM27 UHRF1	2 interactors: CDK1 MBD4
Entrez ID		8930	157313
HPRD ID		04654	13014
Ensembl ID		ENSG00000129071	ENSG00000184661
Uniprot IDs		E9PEE4 O95243	Q69YH5
PDB IDs		3IHO 4DK9 4E9E 4E9F 4E9G 4E9H 4EA4 4EA5 4LG7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Chromosome Organization Chromatin Modification Motor Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Histone Modification Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Organelle Organization Necroptotic Signaling Pathway Cell Differentiation Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Regulation Of DNA Binding Negative Regulation Of Chromosome Organization Rhythmic Process Positive Regulation Of Protein Metabolic Process Immune System Development DNA Methylation On Cytosine Negative Regulation Of Histone H3-K9 Methylation Cell Cycle Negative Regulation Of Circadian Rhythm Regulation Of Histone Modification Negative Regulation Of Histone Methylation Positive Regulation Of Gene Expression Negative Regulation Of Apoptotic Process Negative Regulation Of Viral Transcription Negative Regulation Of Programmed Cell Death Gene Expression Regulation Of Histone H3-K4 Methylation Response To Stimulus Negative Regulation Of Cell Death Regulation Of Myeloid Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cellular Nitrogen Compound Metabolic Process Cellular Response To Stimulus	Mitotic G2 DNA Damage Checkpoint G2 DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Pronuclear Fusion Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Depyrimidination Regulation Of Schwann Cell Differentiation Base-excision Repair, AP Site Formation Pyrimidine Deoxyribonucleotide Catabolic Process DNA Repair Protein Localization To Kinetochore Mitotic Cell Cycle Process Protein Localization To Chromosome, Centromeric Region Positive Regulation Of Protein Import Into Nucleus, Translocation Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Regulation Of Protein Import Into Nucleus, Translocation Deoxyribose Phosphate Catabolic Process Regulation Of Cell Cycle Ventricular Cardiac Muscle Cell Development Apoptotic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Copper Ion Programmed Cell Death Cell Cycle Process Cell Death Death DNA Metabolic Process Deoxyribonucleotide Catabolic Process Ventricular Cardiac Muscle Cell Differentiation Protein Localization To Chromosome Positive Regulation Of Cardiac Muscle Cell Proliferation Mitotic Nuclear Envelope Disassembly Positive Regulation Of Heart Growth Cell Cycle Histone Phosphorylation Nuclear Envelope Disassembly Regulation Of Cardiac Muscle Cell Proliferation Peptidyl-threonine Phosphorylation Chromosome Condensation Positive Regulation Of Organ Growth Response To Amine Cellular Response To Stress
Tagcloud ?		aa aetiology alopecia anagen areata ccl5 dnmt1 ehmt2 ep300 g9a hair hdac2 hdac7 jarid1a jmjd2a jmjd2b jmjd2c kdm1a kdm4a kdm4b kdm4c kdm5a lsd1 mbd1 methylcytosine pbmcs rantes set7 setd7	4c 4cs attenuation bl6j c57 ccnd2 cdc5 crebbp dapk3 demethylase e15 forebrains il6ralpha ipa jmjd2a jmjd2b kd modifier ne neuroectodermal nscs pft pifithrin signatures tfpi timp2 trimethyl tumourigenic warrants
Tagcloud (Difference) ?		aa aetiology alopecia anagen areata ccl5 dnmt1 ehmt2 ep300 g9a hair hdac2 hdac7 jarid1a jmjd2c kdm1a kdm4a kdm4b kdm4c kdm5a lsd1 mbd1 methylcytosine pbmcs rantes set7 setd7	4c 4cs attenuation bl6j c57 ccnd2 cdc5 crebbp dapk3 demethylase e15 forebrains il6ralpha ipa kd modifier ne neuroectodermal nscs pft pifithrin signatures tfpi timp2 trimethyl tumourigenic warrants
Tagcloud (Intersection) ?		jmjd2a jmjd2b