MBD4 and CDCA2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MBD4	CDCA2
Description		methyl-CpG binding domain 4, DNA glycosylase	cell division cycle associated 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	DNA Binding Satellite DNA Binding Catalytic Activity DNA Endonuclease Activity Protein Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity Hydrolase Activity DNA N-glycosylase Activity	Protein Phosphatase Regulator Activity
	Biological Process	DNA Repair DNA Damage Response Response To Estradiol Depyrimidination	Chromosome Segregation Regulation Of Mitotic Nuclear Division Cell Division
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Appendicular lean mass ( 33097823) HDL cholesterol levels ( 32203549) Hip index ( 34021172) Major depressive disorder ( 27479909) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Systolic blood pressure x quantitative lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373) Triglyceride levels ( 32203549) Visceral adipose tissue volume ( 34128465)
Interacting Genes		18 interacting genes: APP CDCA2 CSNK2B DNMT3B FADD FAS HDAC1 KDM1A MLH1 NAT2 RSPH1 SIN3A SUV39H1 TRIM27 TRIM55 TRIM63 UBE2I UHRF1	4 interacting genes: CDK1 MBD4 PPP1CA PPP2R5A
Entrez ID		8930	157313
HPRD ID		04654	13014
Ensembl ID		ENSG00000129071	ENSG00000184661
Uniprot IDs		O95243	A8K8Z0 B7Z5Q5 E9PEI0 Q69YH5
PDB IDs		2MOE 3IHO 4DK9 4E9E 4E9F 4E9G 4E9H 4EA4 4EA5 4LG7 4OFA 4OFE 4OFH 5CHZ 6VJW 7KZ0 7KZ1 7KZG	5INB 5IOH 5SW9
Enriched GO Terms of Interacting Partners?		Epigenetic Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process CD95 Death-inducing Signaling Complex Heterochromatin Formation Death-inducing Signaling Complex Protein Modification Process Heterochromatin Condensed Nuclear Chromosome Transferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Necroptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme Binding Chromosome Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Motor Neuron Apoptotic Process Negative Regulation Of Gene Expression Cellular Response To Catecholamine Stimulus Response To Catecholamine SUMO Transferase Activity Positive Regulation Of Multicellular Organismal Process PML Body Nucleus Sin3-type Complex Macromolecule Metabolic Process Synaptonemal Complex Identical Protein Binding Negative Regulation Of Stem Cell Population Maintenance Regulation Of Primary Metabolic Process Positive Regulation Of Developmental Process Protein Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Neuron Maturation Immune System Process	DNA Metabolic Process Pronuclear Fusion Regulation Of Circadian Rhythm Mitotic DNA-templated DNA Replication DNA Damage Response DNA Repair Cyclin B1-CDK1 Complex Pyrimidine-containing Compound Metabolic Process Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Regulation Of Generation Of Precursor Metabolites And Energy RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Chromosome, Telomeric Region Cyclin-dependent Protein Kinase Activity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Satellite DNA Binding Thymidine Metabolic Process Golgi Disassembly Nuclear DNA Replication Rhythmic Process Thymidine Biosynthetic Process Histone Kinase Activity Glycogen Granule PTW/PP1 Phosphatase Complex Kinase Inhibitor Activity Phosphate-containing Compound Metabolic Process RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Depyrimidination Response To Metal Ion Positive Regulation Of Mitotic Sister Chromatid Segregation RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromosome Organization Ventricular Cardiac Muscle Cell Development Regulation Of Translational Initiation In Response To Stress Double-strand Break Repair Via Alternative Nonhomologous End Joining Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand DNA N-glycosylase Activity Mitotic Nuclear Membrane Disassembly Cilium Disassembly Cellular Response To Stress Pyrimidine Nucleoside Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?