MBD4 and SUV39H1

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		MBD4	SUV39H1
Description		methyl-CpG binding domain 4, DNA glycosylase	SUV39H1 histone lysine methyltransferase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Chromosome, Centromeric Region Heterochromatin Condensed Nuclear Chromosome Nucleus Nuclear Lamina Nucleoplasm Chromatin Silencing Complex Chromosome Nucleolus Plasma Membrane Membrane Cytoplasmic Vesicle RDNA Heterochromatin ENoSc Complex
	Molecular Function	DNA Binding Satellite DNA Binding Catalytic Activity DNA Endonuclease Activity Protein Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity Hydrolase Activity DNA N-glycosylase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Trimethyltransferase Activity
	Biological Process	DNA Repair DNA Damage Response Response To Estradiol Depyrimidination	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Formation Blastocyst Hatching Regulation Of DNA Repair Chromatin Organization RRNA Processing DNA Damage Response Circadian Rhythm Determination Of Adult Lifespan Cell Differentiation Regulation Of Bone Mineralization Heterochromatin Formation Methylation Regulation Of Multicellular Organism Growth Cellular Response To Glucose Starvation Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Cell Cycle Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By Glucose Rhythmic Process Cellular Response To Hypoxia Energy Homeostasis Regulation Of Cellular Senescence
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1	PKMTs methylate histone lysines SIRT1 negatively regulates rRNA expression
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: APP CDCA2 CSNK2B DNMT3B FADD FAS HDAC1 KDM1A MLH1 NAT2 RSPH1 SIN3A SUV39H1 TRIM27 TRIM55 TRIM63 UBE2I UHRF1	137 interacting genes: ATE1 ATF3 ATP6V1B1 BAHD1 BCL11B C4orf17 C8orf74 CBX1 CBX4 CBX5 CDC23 CDCA4 CDCA7L CEP70 CFAP100 CLK3 CRBN CREBBP CRELD2 DBF4B DCAF8 DNMT1 DNMT3A DNMT3B DVL3 ELOF1 EP300 ESR1 EZH2 FGD5 FOXR2 FRMD6 FUS FYN GOLGA6L9 GPATCH2L GTF2H2C_2 GTPBP2 H3-3A H3-4 H3-5 H3C1 H3C15 HDAC1 HDAC2 HDAC3 HDAC5 HOOK2 HOXA1 HOXC4 ID1 ID2 IGFBP4 IL16 ING4 INTS2 KDM1A KLF15 KLHDC4 KLHL20 KRT31 KRTAP10-7 KRTAP10-8 LDHAL6B LENG8 LHX8 LINC02875 LNX1 LOXL4 LZTS2 MALT1 MBD1 MBD4 MCRS1 MSANTD3 MTF2 MTO1 MYOD1 NR1H2 NR1H3 ODAD3 OPA3 PADI6 PHF19 PML PNKP PPP1R16A PRIM2 PRMT6 PSMC1 RASSF1 RASSF2 RB1 RBBP4 RBBP7 RBL1 RBL2 RIN3 RRP8 RSPO2 RUNX1 SBF1 SLFN12 SMAD1 SMAD5 SPATA24 SPRED1 SPSB1 SRGAP3 STX11 STX19 TEKT4 TEX35 THRA TMEM11 TNFAIP1 TNS2 TRIM41 U2AF1 WDFY3 WIZ ZBTB2 ZBTB24 ZCCHC17 ZKSCAN5 ZNF165 ZNF417 ZNF436 ZNF438 ZNF451 ZNF557 ZNF581 ZNF649 ZNF670 ZNF829 ZRANB1 ZSCAN9
Entrez ID		8930	6839
HPRD ID		04654	02221
Ensembl ID		ENSG00000129071	ENSG00000101945
Uniprot IDs		O95243	O43463
PDB IDs		2MOE 3IHO 4DK9 4E9E 4E9F 4E9G 4E9H 4EA4 4EA5 4LG7 4OFA 4OFE 4OFH 5CHZ 6VJW 7KZ0 7KZ1 7KZG	3MTS
Enriched GO Terms of Interacting Partners?		Epigenetic Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process CD95 Death-inducing Signaling Complex Heterochromatin Formation Death-inducing Signaling Complex Protein Modification Process Heterochromatin Condensed Nuclear Chromosome Transferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Necroptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme Binding Chromosome Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Motor Neuron Apoptotic Process Negative Regulation Of Gene Expression Cellular Response To Catecholamine Stimulus Response To Catecholamine SUMO Transferase Activity Positive Regulation Of Multicellular Organismal Process PML Body Nucleus Sin3-type Complex Macromolecule Metabolic Process Synaptonemal Complex Identical Protein Binding Negative Regulation Of Stem Cell Population Maintenance Regulation Of Primary Metabolic Process Positive Regulation Of Developmental Process Protein Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Neuron Maturation Immune System Process	Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Chromatin Organization Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleoplasm Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Primary Metabolic Process DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Binding Regulation Of Metabolic Process Heterochromatin Formation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Zinc Ion Binding Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process ESC/E(Z) Complex Chromatin Transcription Corepressor Binding Negative Regulation Of Metabolic Process Histone Deacetylase Complex Transcription Corepressor Activity Promoter-specific Chromatin Binding Negative Regulation Of Gene Expression DNA (cytosine-5-)-methyltransferase Activity Protein Lysine Delactylase Activity Chromatin DNA Binding Histone Deacetylase Activity, Hydrolytic Mechanism DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Chromosome, Telomeric Region Negative Regulation Of Muscle Cell Differentiation DNA-binding Transcription Factor Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Lipid Kinase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?