MBD4 and SIN3A

Number of citations of the paper that reports this interaction (PMID 15899845)
20

Data Source:
BioGRID (two hybrid)

		MBD4	SIN3A
Gene Name		methyl-CpG binding domain protein 4	SIN3 transcription regulator family member A
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Kinetochore Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Sin3 Complex Transcriptional Repressor Complex Intercellular Bridge
	Molecular Function	Satellite DNA Binding Endodeoxyribonuclease Activity Protein Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Histone Deacetylase Activity Protein Binding Protein Complex Binding Protein Deacetylase Activity
	Biological Process	DNA Catabolic Process, Endonucleolytic DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Mitotic G2 DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Radiation Depyrimidination	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Hematopoietic Progenitor Cell Differentiation DNA Replication Transcription, DNA-templated Protein Deacetylation Aging Blood Coagulation Response To Organonitrogen Compound Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Histone Deacetylation Positive Regulation Of Chromatin Silencing Cellular Protein Localization Regulation Of Gene Expression, Epigenetic Negative Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Lipid Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Response To Methylglyoxal Cellular Response To Glucose Stimulus Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Histone H3-K27 Acetylation Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Base Excision Repair Depyrimidination Resolution of AP sites via the multiple-nucleotide patch replacement pathway Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected pyrimidine Removal of DNA patch containing abasic residue Base-Excision Repair, AP Site Formation Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Displacement of DNA glycosylase by APE1 Resolution of Abasic Sites (AP sites)	NoRC negatively regulates rRNA expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Height ( 20189936) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		12 interactors: CDCA2 CSNK2B DNMT3B FADD FAS HDAC1 KDM1A MLH1 SIN3A SUV39H1 TRIM27 UHRF1	90 interactors: ARID4A ARID4B BCL6 BCL6B BHLHE40 BRMS1 BRMS1L CBFA2T2 COPS2 CTBP1 CTCF CUL4B DACH1 DDB1 DDX20 DHX30 ETV6 HBP1 HCFC1 HDAC1 HDAC2 HDAC7 HDAC9 HEY2 HIST3H3 HTT IKZF1 IKZF4 ING1 IRF5 KLF10 KLF11 KLF13 KLF16 KLF9 LINC00152 LRCH4 MAD1L1 MBD2 MBD4 MECP2 MEN1 MNT MORF4L2 MXD1 MXD3 MXD4 MXI1 MYB NCOR2 NFKB1 NFKB2 NR2E3 OGT PA2G4 PHB PHF12 PML PRMT5 PTMA RBBP4 RBBP7 RBP1 RBPJ REL RELA RELB RLIM RUNX1T1 SAP18 SAP30 SETDB1 SFPQ SKI SMAD3 SMARCA4 SMARCC1 SMARCE1 SNW1 SPI1 STAT3 SYT1 TAL1 TFCP2 TGIF1 THAP11 TOPORS TP53 TRIM28 ZBTB16
Entrez ID		8930	25942
HPRD ID		04654	09690
Ensembl ID		ENSG00000129071	ENSG00000169375
Uniprot IDs		E9PEE4 O95243	Q96ST3
PDB IDs		3IHO 4DK9 4E9E 4E9F 4E9G 4E9H 4EA4 4EA5 4LG7	1PO4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Chromosome Organization Chromatin Modification Motor Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Histone Modification Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Organelle Organization Necroptotic Signaling Pathway Cell Differentiation Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Regulation Of DNA Binding Negative Regulation Of Chromosome Organization Rhythmic Process Positive Regulation Of Protein Metabolic Process Immune System Development DNA Methylation On Cytosine Negative Regulation Of Histone H3-K9 Methylation Cell Cycle Negative Regulation Of Circadian Rhythm Regulation Of Histone Modification Negative Regulation Of Histone Methylation Positive Regulation Of Gene Expression Negative Regulation Of Apoptotic Process Negative Regulation Of Viral Transcription Negative Regulation Of Programmed Cell Death Gene Expression Regulation Of Histone H3-K4 Methylation Response To Stimulus Negative Regulation Of Cell Death Regulation Of Myeloid Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cellular Nitrogen Compound Metabolic Process Cellular Response To Stimulus	Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Modification Chromosome Organization Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Histone Modification Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Gene Expression, Epigenetic Positive Regulation Of Metabolic Process Regulation Of Cell Proliferation Negative Regulation Of Gene Expression, Epigenetic Organelle Organization Regulation Of Cell Differentiation Regulation Of Chromosome Organization Regulation Of Histone Modification Cell Differentiation
Tagcloud ?		aa aetiology alopecia anagen areata ccl5 dnmt1 ehmt2 ep300 g9a hair hdac2 hdac7 jarid1a jmjd2a jmjd2b jmjd2c kdm1a kdm4a kdm4b kdm4c kdm5a lsd1 mbd1 methylcytosine pbmcs rantes set7 setd7	ablated bcl6 conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Difference) ?		aa aetiology alopecia anagen areata ccl5 dnmt1 ehmt2 ep300 g9a hair hdac2 hdac7 jarid1a jmjd2a jmjd2b jmjd2c kdm1a kdm4a kdm4b kdm4c kdm5a lsd1 mbd1 methylcytosine pbmcs rantes set7 setd7	ablated bcl6 conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Intersection) ?