MBD4 and FAS

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MBD4	FAS
Description		methyl-CpG binding domain 4, DNA glycosylase	Fas cell surface death receptor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Extracellular Region Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Extracellular Exosome
	Molecular Function	DNA Binding Satellite DNA Binding Catalytic Activity DNA Endonuclease Activity Protein Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity Hydrolase Activity DNA N-glycosylase Activity	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Calmodulin Binding Kinase Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	DNA Repair DNA Damage Response Response To Estradiol Depyrimidination	Apoptotic Process Activation-induced Cell Death Of T Cells Immune Response Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Stress-activated MAPK Cascade Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amino Acid Starvation Fas Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein-containing Complex Assembly Cellular Response To Mechanical Stimulus Cellular Response To Hyperoxia Motor Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 FasL/ CD95L signaling
Drugs
Diseases			Esophageal cancer Chronic lymphocytic leukemia (CLL) Hodgkin lymphoma Adult T-cell leukemia
GWAS		Diisocyanate-induced asthma ( 25918132) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Ankylosing spondylitis ( 30946743) Atrioventricular conduction ( 21041692) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Chronic lymphocytic leukemia ( 23770605 24292274 26956414 28165464) Immunoglobulin A ( 20694011) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758)
Interacting Genes		18 interacting genes: APP CDCA2 CSNK2B DNMT3B FADD FAS HDAC1 KDM1A MLH1 NAT2 RSPH1 SIN3A SUV39H1 TRIM27 TRIM55 TRIM63 UBE2I UHRF1	50 interacting genes: ANK3 APAF1 APOA5 ATP6V0B BAG6 BTK CALM1 CASP8 CASP8AP2 CCND3 CD47 CRMP1 DAXX DNAJC5 EEF1A1 EGFR ERG28 EZR FADD FAF1 FAF2 FAIM2 FASLG FBF1 FEM1B FYN GADD45A HIPK3 HNRNPC LCK LRIF1 MBD4 MET PDCD6 PRKCA PTPN13 PTPN6 RAP1A RIPK1 SUMO1 TCAP TMX1 TNFSF13 TRADD TRAF3 TRIP6 UBA7 UBAC1 UBE2I UBQLN1
Entrez ID		8930	355
HPRD ID		04654	00609
Ensembl ID		ENSG00000129071	ENSG00000026103
Uniprot IDs		O95243	A0A8Q3SIR6 K9J972 P25445 Q59FU8
PDB IDs		2MOE 3IHO 4DK9 4E9E 4E9F 4E9G 4E9H 4EA4 4EA5 4LG7 4OFA 4OFE 4OFH 5CHZ 6VJW 7KZ0 7KZ1 7KZG	1DDF 2NA7 3EWT 3EZQ 3THM 3TJE
Enriched GO Terms of Interacting Partners?		Epigenetic Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process CD95 Death-inducing Signaling Complex Heterochromatin Formation Death-inducing Signaling Complex Protein Modification Process Heterochromatin Condensed Nuclear Chromosome Transferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Necroptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme Binding Chromosome Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Motor Neuron Apoptotic Process Negative Regulation Of Gene Expression Cellular Response To Catecholamine Stimulus Response To Catecholamine SUMO Transferase Activity Positive Regulation Of Multicellular Organismal Process PML Body Nucleus Sin3-type Complex Macromolecule Metabolic Process Synaptonemal Complex Identical Protein Binding Negative Regulation Of Stem Cell Population Maintenance Regulation Of Primary Metabolic Process Positive Regulation Of Developmental Process Protein Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Neuron Maturation Immune System Process	Cell Death Regulation Of Programmed Cell Death Apoptotic Process Programmed Cell Death Regulation Of Apoptotic Process Apoptotic Signaling Pathway Death Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Death-inducing Signaling Complex Regulation Of Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cytosol Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Tumor Necrosis Factor Receptor Binding Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Macrophage Differentiation Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Ripoptosome CD95 Death-inducing Signaling Complex Positive Regulation Of Intracellular Signal Transduction Kinase Binding Regulation Of Macrophage Differentiation Regulation Of Primary Metabolic Process Negative Regulation Of Transporter Activity Identical Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of Signaling Response To Mechanical Stimulus Necroptotic Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Protein-macromolecule Adaptor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Phospholipase Activator Activity
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