RAD23B and USP25

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RAD23B	USP25
Description		RAD23 nucleotide excision repair protein B	ubiquitin specific peptidase 25
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol XPC Complex	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Proteasome Binding DNA Damage Sensor Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin-like Protein Peptidase Activity Ubiquitin Protein Ligase Binding SUMO Binding Ubiquitin Binding ATPase Binding Deubiquitinase Activity
	Biological Process	DNA Repair Nucleotide-excision Repair DNA Damage Response Spermatogenesis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Embryonic Organ Development Cellular Response To Interleukin-7	Proteolysis Protein Deubiquitination Regulation Of Protein Stability Cellular Response To Oxidative Stress Protein Modification Process Interleukin-17A-mediated Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Response To Oxidative Stress Negative Regulation Of Interleukin-17-mediated Signaling Pathway Negative Regulation Of ERAD Pathway
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle Josephin domain DUBs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER	Ub-specific processing proteases
Drugs
Diseases
GWAS		Body mass index ( 20966902) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 21263130) Chronotype ( 30696823) Cutaneous malignant melanoma ( 26237428) Melanoma ( 28212542) Prostate cancer ( 23023329)	Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Severe autoimmune type 2 diabetes ( 34737425) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		31 interacting genes: ADRM1 ATXN3 CALM1 CEBPA DBI DEAF1 HIP1 HMGB1 MKRN1 MLH1 MPG NGLY1 OGT PAQR3 PAX3 PNMA5 POU6F2 PSMD4 PUF60 RPA1 RSC1A1 TAX1BP1 TDG UBA2 UBB UBC UBE3A USP25 WWP2 XPC ZFAND5	37 interacting genes: ACTA1 ARMC8 CDC73 CNTN1 EIF4A3 FBXL17 FLNC GAPDH GDI1 MAGEB4 MAVS MID2 MT2A NAP1L3 PAX6 PUS10 RAD23A RAD23B RPS10-NUDT3 RSL1D1 SENP1 SKIL SNRNP70 SUMO1 SUMO2 SUMO3 SYK TMEM43 TNKS TNKS2 TUBB UBC UBE2I VPS45 YARS1 ZNF426 ZNF841
Entrez ID		5887	29761
HPRD ID		06772	05296
Ensembl ID		ENSG00000119318	ENSG00000155313
Uniprot IDs		B7Z4W4 P54727	Q9UHP3
PDB IDs		1P1A 1PVE 1UEL 8EBS 8EBV 8EBW	2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM
Enriched GO Terms of Interacting Partners?		Nucleus Macromolecule Metabolic Process Damaged DNA Binding Base-excision Repair SUMO Binding Macromolecule Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Regulation Of Proteolysis Nucleoplasm Modification-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Ubiquitin-dependent Protein Catabolic Process Mismatch Repair Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis DNA Repair Condensed Chromosome Single-stranded DNA Binding Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Bubble DNA Binding Protein Ubiquitination Protein Catabolic Process Nucleic Acid Metabolic Process Nucleotide-excision Repair DNA N-glycosylase Activity Protein Polyubiquitination Mismatched DNA Binding Proteasomal Protein Catabolic Process Proteasome Complex Positive Regulation Of TORC1 Signaling Protein Metabolic Process DNA Metabolic Process Protein Tag Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Base-excision Repair, AP Site Formation Protein Modification Process DNA Damage Response Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of TOR Signaling Protein Binding Regulation Of Primary Metabolic Process DNA Binding Regulation Of TORC1 Signaling Cell Development	Presynaptic Cytosol Protein Tag Activity Protein Sumoylation Postsynaptic Cytosol Nucleus Post-translational Protein Modification Protein Modification By Small Protein Conjugation PML Body Protein Poly-ADP-ribosylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Ubiquitin-like Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Small Protein Activating Enzyme Binding Positive Regulation Of Telomere Capping Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Glutamatergic Synapse Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity Regulation Of Telomere Capping Protein Localization To Organelle Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Cytosol Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Proteasome Binding Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-specific Protease Binding Cellular Response To Cadmium Ion SUMO Transferase Activity Transcription Factor Binding Nuclear Pore NAD+-protein Mono-ADP-ribosyltransferase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Response To Cytokine
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