GSTP1 and FHL5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GSTP1	FHL5
Description		glutathione S-transferase pi 1	four and a half LIM domains 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Cytosol Vesicle Secretory Granule Lumen Extracellular Exosome TRAF2-GSTP1 Complex Ficolin-1-rich Granule Lumen	Nucleus Z Disc
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Fatty Acid Binding Protein Binding JUN Kinase Binding Toxic Substance Binding Transferase Activity Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity S-nitrosoglutathione Binding Dinitrosyl-iron Complex Binding Nitric Oxide Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Reactive Oxygen Species Negative Regulation Of Acute Inflammatory Response Lipid Metabolic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Central Nervous System Development Response To Toxic Substance Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Oligodendrocyte Development Animal Organ Regeneration Response To Nutrient Levels Response To Estradiol Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Superoxide Anion Generation Response To L-ascorbic Acid Common Myeloid Progenitor Cell Proliferation Nitric Oxide Storage Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Amino Acid Negative Regulation Of MAPK Cascade Linoleic Acid Metabolic Process Response To Ethanol Negative Regulation Of JNK Cascade Negative Regulation Of Fibroblast Proliferation Hepoxilin Biosynthetic Process Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Cell-matrix Adhesion Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Smooth Muscle Cell Chemotaxis Cellular Oxidant Detoxification Glutathione Derivative Biosynthetic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Glutathione conjugation Detoxification of Reactive Oxygen Species Neutrophil degranulation Paracetamol ADME
Drugs		Glutathione Troglitazone Clozapine Etacrynic acid Clomipramine (9R,10R)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene S-Hydroxycysteine Cibacron Blue Glutathione sulfonic acid Glutathione disulfide Deoxycholic acid Deoxycholic acid S-(4-nitrobenzyl)glutathione 2-(N-morpholino)ethanesulfonic acid S-Hexylglutathione Canfosfamide Ezatiostat Exisulind S-NONYL-CYSTEINE S-(4-BROMOBENZYL)CYSTEINE Curcumin Dinitrochlorobenzene Hypericin Curcumin sulfate
Diseases		Prostate cancer
GWAS		A body shape index ( 34021172) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)	Cerebral blood flow ( 28627999) Cluster headache ( 34184781) Coronary artery disease ( 29212778) Coronary heart disease ( 22319020) Headache ( 29397368) Metabolite levels ( 23823483) Migraine ( 27322543 27182965 23793025 22683712) Migraine - clinic-based ( 23793025) Migraine without aura ( 27322543 23793025) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Pulse pressure ( 30578418) Spatial memory ( 31596458)
Interacting Genes		39 interacting genes: ADAMTSL4 APPBP2 CARD10 CEBPA CYSRT1 FANCC FBXO8 FHL5 HOXA1 KRT31 KRT33B KRT34 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP3-1 KRTAP3-3 KRTAP6-2 LRP2BP MAPK8 MLH1 MTUS2 NBPF19 NOTCH2NLA OGT PNO1 PRDX6 PTN RNF26 SCAF1 SH3GLB1 SUMO4 TGM1 TGM2 TRAF2 ZNF655	89 interacting genes: ABI2 ADAM12 ADAMTSL5 AGXT ANKRD55 ANKS1A ATOSB BANP BBC3 BCL6B CATSPER1 CDC20B CFP CNNM3 COIL CREB1 CREM CRYBA2 CRYBA4 CTSZ DCDC2B DLGAP4 DMRT3 DNAL4 DTX2 FARS2 FEZF1 FHL2 GARIN6 GPS2 GSTP1 HAPLN2 HCK HDX HEY2 HOXA1 HOXB9 IL16 IP6K3 KIF17 KIR2DL4 LMO2 LRRC41 MAGOHB MISP MYOZ3 NEK6 NPDC1 NUFIP2 OTX1 PIN1 PLEKHA2 PLEKHN1 PPP1R18 QRICH1 RAB26 RAB3IL1 RPS21 SAXO1 SAXO4 SCNM1 SDCBP SEC31A SHFL SLIT1 SMAD1 SPRY1 SRF TUSC2 TXN2 YPEL3 ZBTB16 ZNF124 ZNF23 ZNF250 ZNF251 ZNF408 ZNF417 ZNF440 ZNF446 ZNF564 ZNF581 ZNF587 ZNF613 ZNF688 ZNF764 ZNF766 ZNF792 ZNHIT1
Entrez ID		2950	9457
HPRD ID		00614	05497
Ensembl ID		ENSG00000084207	ENSG00000112214
Uniprot IDs		P09211 V9HWE9	Q5TD97
PDB IDs		10GS 11GS 12GS 13GS 14GS 16GS 17GS 18GS 19GS 1AQV 1AQW 1AQX 1EOG 1EOH 1GSS 1KBN 1LBK 1MD3 1MD4 1PGT 1PX6 1PX7 1ZGN 20GS 22GS 2A2R 2A2S 2GSS 2J9H 2PGT 3CSH 3CSI 3CSJ 3DD3 3DGQ 3GSS 3GUS 3HJM 3HJO 3HKR 3IE3 3KM6 3KMN 3KMO 3N9J 3PGT 4GSS 4PGT 5DAK 5DAL 5DCG 5DDL 5DJL 5DJM 5GSS 5J41 5JCW 5L6X 5X79 6AP9 6GSS 6LLX 6Y1E 7BIA 7GSS 7XBA 8GSS 9GSS	1X68
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Protein-glutamine Gamma-glutamyltransferase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Nucleus Heart Trabecula Formation Regulation Of Primary Metabolic Process Identical Protein Binding Regulation Of Macromolecule Metabolic Process Zinc Ion Binding ATF4-CREB1 Transcription Factor Complex Regulation Of Metabolic Process Tangential Migration From The Subventricular Zone To The Olfactory Bulb
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