GSTP1 and NOTCH2NL

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GSTP1	NOTCH2NL
Gene Name		glutathione S-transferase pi 1	notch 2 N-terminal like
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Intracellular Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Vesicle Extracellular Vesicular Exosome TRAF2-GSTP1 Complex	Extracellular Region Cytoplasm
	Molecular Function	Glutathione Transferase Activity Protein Binding JUN Kinase Binding Kinase Regulator Activity S-nitrosoglutathione Binding Dinitrosyl-iron Complex Binding Nitric Oxide Binding	Calcium Ion Binding
	Biological Process	Response To Reactive Oxygen Species Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Protein Kinase Activity Glutathione Metabolic Process Xenobiotic Metabolic Process Central Nervous System Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Superoxide Anion Generation Common Myeloid Progenitor Cell Proliferation Nitric Oxide Storage Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of JUN Kinase Activity Small Molecule Metabolic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Lipopolysaccharide Negative Regulation Of Monocyte Chemotactic Protein-1 Production Glutathione Derivative Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Notch Signaling Pathway Multicellular Organismal Development Cell Differentiation
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Detoxification of Reactive Oxygen Species Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione Clomipramine (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene S-Hydroxycysteine Cibacron Blue Glutathione Sulfonic Acid S-(P-Nitrobenzyl)Glutathione 2-(N-Morpholino)-Ethanesulfonic Acid Glycerol S-Hexylglutathione Carboxymethylenecysteine S-NONYL-CYSTEINE S-(4-BROMOBENZYL)CYSTEINE
Diseases
GWAS
Protein-Protein Interactions		15 interactors: APPBP2 FANCC KRT31 KRTAP10-3 KRTAP10-7 KRTAP10-9 MAPK8 MLH1 NOTCH2NL PNO1 PTN SCAF1 SUMO4 TGM2 TRAF2	241 interactors: ACY3 ADAMTSL3 ADAMTSL5 ADCK5 AES ALDH3B1 ALPI AQP1 AQP5 ARID3A ASPSCR1 ATG9A BCL6B BLCAP BMP7 C11orf87 C16orf59 C19orf66 C5orf60 CA6 CARHSP1 CARKD CATSPER1 CCDC26 CCDC93 CCER1 CD164 CDK5R1 CERK CHCHD3 CHDH CHIC2 CHRD CHRNG CLDN2 CLEC18A COL8A1 CRACR2A CRCT1 CREB5 CSF1 CST2 CST9L CTSG CTSZ CXCL16 CXCL5 DGCR6 DHRS1 DMRT3 DNAL4 DOCK2 EFNA3 EIF4E2 ELANE EPHB6 ESR2 FAAH FAM124B FAM71C FAM71E2 FAM74A4 FARS2 FASLG FBXL18 FBXW5 FOXB1 FRS3 GABRD GATA2 GEM GFOD1 GIP GLP1R GLRX3 GLYAT GNAI2 GNE GNMT GSTP1 GTF3C5 HBZ HCK HIST1H2AK HOXA1 HPCAL1 HSBP1 HSD3B7 HSPA12B HSPBP1 HSPD1 ICAM4 IFI30 IL2RG INPP5D ITGB2 ITGB5 JOSD1 KCTD15 KIF1A KLHL38 KLK8 KRT20 KRT83 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP13-3 KRTAP26-1 KRTAP3-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LIMS2 LIN7A LINC00526 LINC00656 LMO2 LNX1 LONRF3 LRCH4 LRFN4 MAPKBP1 MARK4 MATN3 MFI2 MRGBP MRPL40 MTA1 MVP MXD3 MXI1 NAB2 NEU2 NMU NMUR2 NPBWR2 NPDC1 NPPB NR1D2 NUBP2 P2RX4 PCED1A PCED1B PCSK5 PDE9A PGLS PID1 PIGS PLSCR4 POLR2G POM121L8P POMGNT2 PPAP2C PRKAA2 PRPF31 PRPS2 PSMA1 PSMG2 PTGER3 PTPMT1 PTPN23 PVR PVRL2 PVRL3 QPRT R3HDM2 RAB3IL1 RAMP3 RCHY1 RECK RET RGL2 RPS28 RTN4RL1 SCNM1 SDCBP SELM SEMA4C SLC22A23 SLC23A1 SLC25A10 SLC25A6 SLC6A20 SMARCD2 SMARCE1 SMCP SMOC1 SNAI1 SPATA8 SPG7 SPINK2 SPRY1 STK16 TBC1D10C TBC1D16 THAP7 THEMIS2 TINAGL1 TMEM150A TMEM231 TMEM41A TNIP3 TNK2 TNP2 TRIM27 TRIM42 TRPV6 TSPAN4 TXNDC5 UBQLN4 UTP23 UXT WDR25 WT1-AS XCL2 YIPF3 ZFYVE21 ZNF124 ZNF32 ZNF417 ZNF439 ZNF440 ZNF446 ZNF581 ZNF587
Entrez ID		2950	388677
HPRD ID		00614	14833
Ensembl ID		ENSG00000084207	ENSG00000213240
Uniprot IDs		P09211	Q7Z3S9
PDB IDs		10GS 11GS 12GS 13GS 14GS 16GS 17GS 18GS 19GS 1AQV 1AQW 1AQX 1EOG 1EOH 1GSS 1KBN 1LBK 1MD3 1MD4 1PGT 1PX6 1PX7 1ZGN 20GS 22GS 2A2R 2A2S 2GSS 2J9H 2PGT 3CSH 3CSI 3CSJ 3DD3 3DGQ 3GSS 3GUS 3HJM 3HJO 3HKR 3IE3 3KM6 3KMN 3KMO 3N9J 3PGT 4GSS 4PGT 5GSS 6GSS 7GSS 8GSS 9GSS
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitric Oxide Cellular Response To Reactive Oxygen Species Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Programmed Necrotic Cell Death Necrotic Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Toll-like Receptor 4 Signaling Pathway Response To Oxidative Stress Protein Complex Assembly Negative Regulation Of Mitotic Recombination Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Response To Inorganic Substance Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Cellular Response To Inorganic Substance Activation Of Innate Immune Response Regulation Of Protein Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death JUN Phosphorylation Positive Regulation Of Cell Death Positive Regulation Of Deacetylase Activity Salivary Gland Cavitation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Innate Immune Response Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity Cellular Response To Stress Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Spindle Midzone Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Positive Regulation Of Protein Homodimerization Activity Resolution Of Meiotic Recombination Intermediates Regulation Of Innate Immune Response Germ Cell Development Peptidyl-lysine Modification Regulation Of Immunoglobulin Secretion Protein Homooligomerization	Developmental Process Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Locomotion Negative Regulation Of Biosynthetic Process Multicellular Organismal Development Response To Lipid Cell Motility Cellular Response To Lipid Movement Of Cell Or Subcellular Component Response To Lipopolysaccharide Positive Regulation Of Immune Response To Tumor Cell RNA Biosynthetic Process Transcription, DNA-templated System Development Response To Molecule Of Bacterial Origin Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To External Stimulus Susceptibility To T Cell Mediated Cytotoxicity Formation Of Primary Germ Layer Cellular Response To Stimulus Cellular Process Negative Regulation Of Transcription, DNA-templated Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Protein Metabolic Process Biosynthetic Process Endodermal Cell Differentiation Cell Migration Regulation Of Metabolic Process Regulation Of Cellular Process Response To Stimulus Gene Expression Nitrogen Compound Metabolic Process Organ Development Keratinization Anatomical Structure Morphogenesis Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Neutrophil Mediated Immunity Extracellular Matrix Organization Extracellular Structure Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Carbon Dioxide Transport Gastrulation Cellular Macromolecule Biosynthetic Process Tissue Development Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Tagcloud ?		abolished acetylcysteine acetyltransferase ap1 boxes chloramphenicol consensus construct detoxication division embryogenesis evolved gggaccctcc h2o2 immediately impairs inducer kappa localizes mad nac proliferating protect redox repression share transfection transferase	a3 a3s a465tmutation anaplastic astrocytoma atrx challenging diffuse distinguish exome gbm gbms glioblastoma gliomas grade idh1 illuminate landscape lethal multiforme oa2 oa3 oligoastrocytoma sequenced signatures
Tagcloud (Difference) ?		abolished acetylcysteine acetyltransferase ap1 boxes chloramphenicol consensus construct detoxication division embryogenesis evolved gggaccctcc h2o2 immediately impairs inducer kappa localizes mad nac proliferating protect redox repression share transfection transferase	a3 a3s a465tmutation anaplastic astrocytoma atrx challenging diffuse distinguish exome gbm gbms glioblastoma gliomas grade idh1 illuminate landscape lethal multiforme oa2 oa3 oligoastrocytoma sequenced signatures
Tagcloud (Intersection) ?