GSTP1 and PNO1

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		GSTP1	PNO1
Name		glutathione S-transferase pi 1	partner of NOB1 homolog
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Cytosol Vesicle Secretory Granule Lumen Extracellular Exosome TRAF2-GSTP1 Complex Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Nucleolus Cytosol Small-subunit Processome
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Fatty Acid Binding Protein Binding JUN Kinase Binding Toxic Substance Binding Transferase Activity Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity S-nitrosoglutathione Binding Dinitrosyl-iron Complex Binding Nitric Oxide Binding	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Reactive Oxygen Species Negative Regulation Of Acute Inflammatory Response Lipid Metabolic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Central Nervous System Development Response To Toxic Substance Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Oligodendrocyte Development Animal Organ Regeneration Response To Nutrient Levels Response To Estradiol Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Superoxide Anion Generation Response To L-ascorbic Acid Common Myeloid Progenitor Cell Proliferation Nitric Oxide Storage Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Amino Acid Negative Regulation Of MAPK Cascade Linoleic Acid Metabolic Process Response To Ethanol Negative Regulation Of JNK Cascade Negative Regulation Of Fibroblast Proliferation Hepoxilin Biosynthetic Process Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Cell-matrix Adhesion Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Smooth Muscle Cell Chemotaxis Cellular Oxidant Detoxification Glutathione Derivative Biosynthetic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Ribosomal Small Subunit Biogenesis
Pathways		Glutathione conjugation Detoxification of Reactive Oxygen Species Neutrophil degranulation Paracetamol ADME	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Glutathione Troglitazone Clozapine Etacrynic acid Clomipramine (9R,10R)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene S-Hydroxycysteine Cibacron Blue Glutathione sulfonic acid Glutathione disulfide Deoxycholic acid Deoxycholic acid S-(4-nitrobenzyl)glutathione 2-(N-morpholino)ethanesulfonic acid S-Hexylglutathione Canfosfamide Ezatiostat Exisulind S-NONYL-CYSTEINE S-(4-BROMOBENZYL)CYSTEINE Curcumin Dinitrochlorobenzene Hypericin Curcumin sulfate	None
Diseases		Prostate cancer	None
GWAS		A body shape index ( 34021172 ) Hip circumference adjusted for BMI ( 34021172 ) Refractive error ( 32231278 ) Waist circumference adjusted for body mass index ( 34021172 )	No GWAS studies recorded
Interacting Genes		39 interacting genes: ADAMTSL4 APPBP2 CARD10 CEBPA CYSRT1 FANCC FBXO8 FHL5 HOXA1 KRT31 KRT33B KRT34 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP3-1 KRTAP3-3 KRTAP6-2 LRP2BP MAPK8 MLH1 MTUS2 NBPF19 NOTCH2NLA OGT PNO1 PRDX6 PTN RNF26 SCAF1 SH3GLB1 SUMO4 TGM1 TGM2 TRAF2 ZNF655	10 interacting genes: ATP5F1C FRZB GSTP1 IGFBP5 KLF6 PDPK1 PICK1 RXRG SGSM2 SUPT5H
Entrez ID		2950	56902
HPRD ID		00614	14250
Ensembl ID		ENSG00000084207	ENSG00000115946
Uniprot IDs		P09211 V9HWE9	Q9NRX1
PDB IDs		10GS 11GS 12GS 13GS 14GS 16GS 17GS 18GS 19GS 1AQV 1AQW 1AQX 1EOG 1EOH 1GSS 1KBN 1LBK 1MD3 1MD4 1PGT 1PX6 1PX7 1ZGN 20GS 22GS 2A2R 2A2S 2GSS 2J9H 2PGT 3CSH 3CSI 3CSJ 3DD3 3DGQ 3GSS 3GUS 3HJM 3HJO 3HKR 3IE3 3KM6 3KMN 3KMO 3N9J 3PGT 4GSS 4PGT 5DAK 5DAL 5DCG 5DDL 5DJL 5DJM 5GSS 5J41 5JCW 5L6X 5X79 6AP9 6GSS 6LLX 6Y1E 7BIA 7GSS 7XBA 8GSS 9GSS	6G18 6G4S 6G4W 6G51 6G53 6G5I 6ZUO 6ZXD 6ZXE 7MQ8 7MQ9 7MQA 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 8ZDC 8ZDD
GO Terms Enriched among Interactors		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Protein-glutamine Gamma-glutamyltransferase Activity	Cellular Developmental Process Negative Regulation Of Hepatocyte Differentiation Negative Regulation Of Growth Cell Development Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Proliferation Dinitrosyl-iron Complex Binding S-nitrosoglutathione Binding Response To Epidermal Growth Factor Nitric Oxide Storage Negative Regulation Of Muscle Hypertrophy Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Skeletal Muscle Hypertrophy 3-phosphoinositide-dependent Protein Kinase Activity Glial Cell Development Regulation Of Cartilage Development Regulation Of Smooth Muscle Cell Migration Response To Peptide Hormone Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion TRAF2-GSTP1 Complex DSIF Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cellular Response To Insulin Stimulus Regulation Of Cell Growth Insulin-like Growth Factor Binding Protein Complex Regulation Of Cell Population Proliferation Regulation Of Cell Migration Glutathione Derivative Biosynthetic Process Cellular Response To Cell-matrix Adhesion Insulin-like Growth Factor Ternary Complex Membrane Curvature Sensor Activity Epithelial Cell Development Convergent Extension Involved In Organogenesis Regulation Of Cell Motility Negative Regulation Of Smooth Muscle Cell Chemotaxis Nitric Oxide Binding Response To L-ascorbic Acid Mammary Gland Involution Positive Regulation Of Sarcomere Organization