GSTP1 and CARD10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GSTP1	CARD10
Description		glutathione S-transferase pi 1	caspase recruitment domain family member 10
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Cytosol Vesicle Secretory Granule Lumen Extracellular Exosome TRAF2-GSTP1 Complex Ficolin-1-rich Granule Lumen	Immunological Synapse Cytoplasm CBM Complex
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Fatty Acid Binding Protein Binding JUN Kinase Binding Toxic Substance Binding Transferase Activity Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity S-nitrosoglutathione Binding Dinitrosyl-iron Complex Binding Nitric Oxide Binding	Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Reactive Oxygen Species Negative Regulation Of Acute Inflammatory Response Lipid Metabolic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Central Nervous System Development Response To Toxic Substance Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Oligodendrocyte Development Animal Organ Regeneration Response To Nutrient Levels Response To Estradiol Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Superoxide Anion Generation Response To L-ascorbic Acid Common Myeloid Progenitor Cell Proliferation Nitric Oxide Storage Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Response To Amino Acid Negative Regulation Of MAPK Cascade Linoleic Acid Metabolic Process Response To Ethanol Negative Regulation Of JNK Cascade Negative Regulation Of Fibroblast Proliferation Hepoxilin Biosynthetic Process Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Cell-matrix Adhesion Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Smooth Muscle Cell Chemotaxis Cellular Oxidant Detoxification Glutathione Derivative Biosynthetic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Protein-containing Complex Assembly Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Localization To Nucleus
Pathways		Glutathione conjugation Detoxification of Reactive Oxygen Species Neutrophil degranulation Paracetamol ADME
Drugs		Glutathione Troglitazone Clozapine Etacrynic acid Clomipramine (9R,10R)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene S-Hydroxycysteine Cibacron Blue Glutathione sulfonic acid Glutathione disulfide Deoxycholic acid Deoxycholic acid S-(4-nitrobenzyl)glutathione 2-(N-morpholino)ethanesulfonic acid S-Hexylglutathione Canfosfamide Ezatiostat Exisulind S-NONYL-CYSTEINE S-(4-BROMOBENZYL)CYSTEINE Curcumin Dinitrochlorobenzene Hypericin Curcumin sulfate
Diseases		Prostate cancer
GWAS		A body shape index ( 34021172) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)	Autoimmune hepatitis type-1 ( 24768677) Low vWF levels ( 26486471) Optic disc area ( 21307088 25631615 28073927 31798171) Optic disc size ( 31809533) Refractive error ( 32231278) Vertical cup-disc ratio ( 25241763 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		39 interacting genes: ADAMTSL4 APPBP2 CARD10 CEBPA CYSRT1 FANCC FBXO8 FHL5 HOXA1 KRT31 KRT33B KRT34 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP3-1 KRTAP3-3 KRTAP6-2 LRP2BP MAPK8 MLH1 MTUS2 NBPF19 NOTCH2NLA OGT PNO1 PRDX6 PTN RNF26 SCAF1 SH3GLB1 SUMO4 TGM1 TGM2 TRAF2 ZNF655	105 interacting genes: ATXN7 BAHD1 BCL10 BCL6B C8orf48 CARD9 CATSPER1 CBX8 CCDC116 CCDC187 CDC37 CEP95 CHIC2 CNNM3 CWF19L2 CXCL16 CYSRT1 DHX57 DOCK2 DRC4 DUSP26 FAM47B FOXD4L3 GADD45GIP1 GFAP GIPC1 GPATCH2L GSE1 GSTP1 HBZ HOXB9 IKBKG IL16 JOSD1 KANK2 KDM1A KEAP1 KLHL12 KRT75 KRTAP10-8 KRTAP12-3 KRTAP26-1 KRTAP9-2 KRTAP9-3 LENG1 MAGOHB METTL17 MITD1 MYPOP NME7 OLIG3 PIBF1 PKP1 PNKP PRDM14 PRPF18 PRPF3 PRR35 PTCD1 PTGDS RIN1 SCNM1 SEMA3B SPATA18 SPMIP2 TBC1D22B TBC1D26 TFAP2D TMEM43 TRIM27 TRIM41 USP54 UTP14C ZBTB26 ZFP1 ZNF10 ZNF12 ZNF165 ZNF180 ZNF202 ZNF223 ZNF239 ZNF250 ZNF285 ZNF286A ZNF32 ZNF329 ZNF366 ZNF414 ZNF415 ZNF439 ZNF440 ZNF524 ZNF552 ZNF559 ZNF564 ZNF575 ZNF581 ZNF587 ZNF613 ZNF670 ZNF775 ZNF80 ZNF837 ZSCAN25
Entrez ID		2950	29775
HPRD ID		00614	06233
Ensembl ID		ENSG00000084207	ENSG00000100065
Uniprot IDs		P09211 V9HWE9	Q9BWT7
PDB IDs		10GS 11GS 12GS 13GS 14GS 16GS 17GS 18GS 19GS 1AQV 1AQW 1AQX 1EOG 1EOH 1GSS 1KBN 1LBK 1MD3 1MD4 1PGT 1PX6 1PX7 1ZGN 20GS 22GS 2A2R 2A2S 2GSS 2J9H 2PGT 3CSH 3CSI 3CSJ 3DD3 3DGQ 3GSS 3GUS 3HJM 3HJO 3HKR 3IE3 3KM6 3KMN 3KMO 3N9J 3PGT 4GSS 4PGT 5DAK 5DAL 5DCG 5DDL 5DJL 5DJM 5GSS 5J41 5JCW 5L6X 5X79 6AP9 6GSS 6LLX 6Y1E 7BIA 7GSS 7XBA 8GSS 9GSS
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Protein-glutamine Gamma-glutamyltransferase Activity	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process DNA Binding Zinc Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Protein Binding Regulation Of Metabolic Process Nucleus Intermediate Filament Metal Ion Binding DNA-binding Transcription Factor Activity Keratin Filament RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Identical Protein Binding CBM Complex
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