GSTP1 and SCAF1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GSTP1	SCAF1
Gene Name		glutathione S-transferase pi 1	SR-related CTD-associated factor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Intracellular Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Vesicle Extracellular Vesicular Exosome TRAF2-GSTP1 Complex	Nucleus
	Molecular Function	Glutathione Transferase Activity Protein Binding JUN Kinase Binding Kinase Regulator Activity S-nitrosoglutathione Binding Dinitrosyl-iron Complex Binding Nitric Oxide Binding	RNA Binding Protein Domain Specific Binding
	Biological Process	Response To Reactive Oxygen Species Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Protein Kinase Activity Glutathione Metabolic Process Xenobiotic Metabolic Process Central Nervous System Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Superoxide Anion Generation Common Myeloid Progenitor Cell Proliferation Nitric Oxide Storage Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of JUN Kinase Activity Small Molecule Metabolic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Lipopolysaccharide Negative Regulation Of Monocyte Chemotactic Protein-1 Production Glutathione Derivative Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Transcription From RNA Polymerase II Promoter MRNA Processing RNA Splicing
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Detoxification of Reactive Oxygen Species Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione Clomipramine (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene S-Hydroxycysteine Cibacron Blue Glutathione Sulfonic Acid S-(P-Nitrobenzyl)Glutathione 2-(N-Morpholino)-Ethanesulfonic Acid Glycerol S-Hexylglutathione Carboxymethylenecysteine S-NONYL-CYSTEINE S-(4-BROMOBENZYL)CYSTEINE
Diseases
GWAS
Protein-Protein Interactions		15 interactors: APPBP2 FANCC KRT31 KRTAP10-3 KRTAP10-7 KRTAP10-9 MAPK8 MLH1 NOTCH2NL PNO1 PTN SCAF1 SUMO4 TGM2 TRAF2	2 interactors: GSTP1 UBQLN4
Entrez ID		2950	58506
HPRD ID		00614	11604
Ensembl ID		ENSG00000084207	ENSG00000126461
Uniprot IDs		P09211	Q9H7N4
PDB IDs		10GS 11GS 12GS 13GS 14GS 16GS 17GS 18GS 19GS 1AQV 1AQW 1AQX 1EOG 1EOH 1GSS 1KBN 1LBK 1MD3 1MD4 1PGT 1PX6 1PX7 1ZGN 20GS 22GS 2A2R 2A2S 2GSS 2J9H 2PGT 3CSH 3CSI 3CSJ 3DD3 3DGQ 3GSS 3GUS 3HJM 3HJO 3HKR 3IE3 3KM6 3KMN 3KMO 3N9J 3PGT 4GSS 4PGT 5GSS 6GSS 7GSS 8GSS 9GSS
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitric Oxide Cellular Response To Reactive Oxygen Species Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Programmed Necrotic Cell Death Necrotic Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Toll-like Receptor 4 Signaling Pathway Response To Oxidative Stress Protein Complex Assembly Negative Regulation Of Mitotic Recombination Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Response To Inorganic Substance Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Cellular Response To Inorganic Substance Activation Of Innate Immune Response Regulation Of Protein Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death JUN Phosphorylation Positive Regulation Of Cell Death Positive Regulation Of Deacetylase Activity Salivary Gland Cavitation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Innate Immune Response Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity Cellular Response To Stress Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Spindle Midzone Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Positive Regulation Of Protein Homodimerization Activity Resolution Of Meiotic Recombination Intermediates Regulation Of Innate Immune Response Germ Cell Development Peptidyl-lysine Modification Regulation Of Immunoglobulin Secretion Protein Homooligomerization	Nitric Oxide Storage Negative Regulation Of Monocyte Chemotactic Protein-1 Production Nitric Oxide Homeostasis Common Myeloid Progenitor Cell Proliferation Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of JUN Kinase Activity Negative Regulation Of Acute Inflammatory Response Regulation Of Superoxide Anion Generation Negative Regulation Of Interleukin-1 Beta Production Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Glutathione Derivative Biosynthetic Process Negative Regulation Of JNK Cascade Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Response To Cytokine Stimulus Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Interleukin-1 Beta Production Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Chemokine Production Glutathione Metabolic Process Regulation Of Acute Inflammatory Response Negative Regulation Of Leukocyte Proliferation Regulation Of JUN Kinase Activity Negative Regulation Of MAP Kinase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Tumor Necrosis Factor Production Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Fibroblast Proliferation Regulation Of Protein Metabolic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Xenobiotic Stimulus Peptide Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Lipopolysaccharide Negative Regulation Of MAPK Cascade Cellular Response To Molecule Of Bacterial Origin Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Regulation Of ERK1 And ERK2 Cascade
Tagcloud ?		abolished acetylcysteine acetyltransferase ap1 boxes chloramphenicol consensus construct detoxication division embryogenesis evolved gggaccctcc h2o2 immediately impairs inducer kappa localizes mad nac proliferating protect redox repression share transfection transferase
Tagcloud (Difference) ?		abolished acetylcysteine acetyltransferase ap1 boxes chloramphenicol consensus construct detoxication division embryogenesis evolved gggaccctcc h2o2 immediately impairs inducer kappa localizes mad nac proliferating protect redox repression share transfection transferase
Tagcloud (Intersection) ?