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ATXN3 and TRIM63
Number of citations of the paper that reports this interaction (PubMedID
22626734
)
34
Data Source:
BioGRID
(enzymatic study)
ATXN3
TRIM63
Description
ataxin 3
tripartite motif containing 63
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrial Matrix
Lysosome
Lysosomal Membrane
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Membrane
Nuclear Matrix
Mitochondrial Membrane
Nuclear Inclusion Body
Synapse
Nucleus
Cytoplasm
Microtubule
Z Disc
M Band
Contractile Muscle Fiber
Molecular Function
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
ATPase Binding
K63-linked Deubiquitinase Activity
K48-linked Deubiquitinase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Titin Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Microtubule Cytoskeleton Organization
Cytoplasmic Translation
Nucleotide-excision Repair
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Chemical Synaptic Transmission
Nervous System Development
Cellular Response To Starvation
Regulation Of Cell-substrate Adhesion
Protein Deubiquitination
Actin Cytoskeleton Organization
Cellular Response To Nutrient Levels
Cellular Response To Amino Acid Starvation
Cellular Response To Heat
Monoubiquitinated Protein Deubiquitination
Exploration Behavior
TORC1 Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Intermediate Filament Cytoskeleton Organization
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Cellular Response To Misfolded Protein
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Positive Regulation Of ERAD Pathway
Protein Localization To Cytosolic Proteasome Complex
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Muscle Contraction
Signal Transduction
Negative Regulation Of Cardiac Muscle Hypertrophy
Skeletal Muscle Atrophy
Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Protein Ubiquitination
Innate Immune Response
Negative Regulation Of Glycolytic Process
Response To Glucocorticoid
Response To Interleukin-1
Pathways
Josephin domain DUBs
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS
Amyotrophic lateral sclerosis (
29566793
)
Coronary artery calcification (
23870195
)
HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction (
31806883
)
Height (
18391950
18391951
)
Hip circumference adjusted for BMI (
34021172
)
LDL cholesterol levels x loop diuretics use interaction (
31806883
)
Orofacial clefts (
22419666
)
Refractive error (
32231278
)
Waist circumference adjusted for body mass index (
34021172
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Interacting Genes
55 interacting genes:
ANXA7
APP
ARHGAP19
ARHGDIA
ASIC1
CAPN1
CAPN2
CASP1
CDKN1A
CHEK1
CSNK2B
DNM2
EWSR1
GABARAP
GSK3B
KAT2B
KPNA2
MAP1LC3A
MAP1LC3C
MAP3K1
MKNK1
NCOR1
NEDD8
PHAF1
PICK1
PRKN
PSMD7
RAD23A
RAD23B
RFFL
RPS6KA1
SMURF1
SQSTM1
STUB1
SUMO1
TEX11
TK1
TP53
TRAF6
TRIM54
TRIM55
TRIM63
TUBA1A
TUBB
UBB
UBC
UBE2D3
UBE2L3
UBE2S
UBE2W
UBE4B
UBQLN1
USP21
VCP
WWP2
331 interacting genes:
ACBD4
ACD
ACTA1
ADAMTSL4
AEBP2
AGO2
AK1
AKR7A2
ALDOA
ALKBH3
ANKRD1
ANKRD39
APLN
APOBEC4
APP
ARL6IP4
ATP5F1B
ATP5F1D
ATXN3
ATXN3L
ATXN7L1
BAP1
BCAT1
BCHE
BRD4
BRWD1
BTBD9
C10orf88
C1orf35
C3orf36
C8orf74
CADPS
CAMK2A
CAPN3
CARS1
CBX2
CCDC120
CCDC28B
CDK3
CDS2
CENPK
CHMP7
CKB
CKM
COA7
COX4I1
CRCT1
CTAG1A
CTAG1B
CTNNB1
CYB5R2
CYP46A1
CYTOR
DAPL1
DCAF11
DCAF6
DECR2
DEF8
DEK
DES
DMD
DNTTIP1
DOCK7
DYNLT2B
EED
EEF1G
EHHADH
EIF3E
ELAPOR1
ENO3
EPS8L2
ESPL1
EZH2
FAM185A
FANK1
FASTKD1
FERRY3
FHL2
FKBP6
FLNC
FRMD6
FYN
GABPB1
GATA3
GFM1
GLI4
GMEB1
GOLGA2P5
GPRIN2
GPS1
GRB10
HIBADH
HID1
HIRA
HOXA1
HROB
HSPB1
HSPD1
ID1
IFI35
IGF2
IK
IL37
ILF3
INCA1
ING4
INKA1
IQUB
IRF2
IRF3
ITGB5
JADE3
JOSD1
KBTBD4
KCTD15
KIAA0087
KIAA0408
KIAA0825
KIF5A
KLHDC4
KLHL36
KMT2B
KYAT1
LAMA2
LAMTOR5
LAPTM4A
LIMS2
LINC00518
LINC00663
LINC00905
LINC01588
LMCD1
LMO2
LRRC56
LYN
LYNX1
MAGEC3
MALSU1
MAP3K14
MBD4
MBIP
MCM7
MIDN
MIIP
MKI67
MLH3
MPP1
MPZL1
MRPL19
MRPL20-AS1
MRPL41
MSRB3
MYBPC1
MYBPC2
MYBPC3
MYBPHL
MYC
MYCT1
MYH6
MYL2
MYOT
MYOZ1
NDUFA1
NDUFA8
NEB
NEBL
NEFL
NGEF
NOMO1
NR1D2
NRAP
NSD3
NSUN7
NUFIP2
ODF2
OGFOD2
OTUB1
OTUB2
P3H3
PACRGL
PAFAH1B2
PCGF3
PCGF6
PDHB
PDK4
PELI3
PELO
PHC2
PHF23
PIAS1
PIAS2
PIAS3
PIP4K2B
PKM
PLEKHG4
PLXNA3
POLR2E
PPA2
PPARA
PPIE
PRKAB2
PRKACA
PRR30
PRRT1
PSMD4
PYGM
RAI2
RBM14
RELA
REX1BD
RGR
RHEB
RHPN1
RING1
RNASEH1
RNF10
RPS4X
RRAS
RUSC1
RUSC1-AS1
SEC23B
SENP2
SENP3
SET
SGCB
SHFL
SLC6A13
SLFN12
SNAPIN
SNW1
SPATS1
SPRYD7
SPSB1
SPSB2
SQSTM1
SRF
STAM
SUMO2
SYMPK
SYNCRIP
TCAP
TCEAL4
TCP10L
TEX19
THAP3
THRA
TIGD5
TIMM17B
TMBIM1
TMEM35A
TNIP3
TNNC1
TNNI1
TNNI2
TNNI3
TNNT1
TNNT3
TOR1AIP2
TPD52L3
TRAF3IP2
TRIB3
TRIM23
TRIM35
TRIM41
TRIM54
TRIM55
TRIM69
TRMT10B
TSC2
TSC22D4
TTN
TUBGCP4
UBA3
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2G1
UBE2I
UBE2J1
UBE2K
UBE2N
UBE2U
UBE2V2
UCHL1
UCHL3
UCHL5
UNKL
UQCRC1
USP13
USP15
USP2
USP21
USP28
USP33
USP4
USP5
USP7
USP8
UXT
VAC14
VPS37A
WT1
XAGE1B
YJU2B
YOD1
YPEL3
ZBTB17
ZC2HC1C
ZC3H12A
ZC3HC1
ZFYVE19
ZNF124
ZNF20
ZNF302
ZNF333
ZNF345
ZNF431
ZNF436
ZNF460
ZNF566
ZNF57
ZNF581
ZNF597
ZNF649
ZNF653
ZNF667-AS1
ZNF767P
ZNF775
ZNF83
ZSCAN16
Entrez ID
4287
84676
HPRD ID
06131
05843
Ensembl ID
ENSG00000066427
ENSG00000158022
Uniprot IDs
A0A0A0MS38
C9JQV6
P54252
Q969Q1
PDB IDs
1YZB
2AGA
2DOS
2JRI
2KLZ
4WTH
4YS9
2D8U
3DDT
4M3L
Enriched GO Terms of Interacting Partners
?
Ubiquitin Protein Ligase Binding
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Protein Modification Process
Protein Metabolic Process
Macromolecule Catabolic Process
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Cytosol
Post-translational Protein Modification
Cytoplasm
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Protein Catabolic Process
Regulation Of Proteolysis
Macromolecule Metabolic Process
Protein Polyubiquitination
Positive Regulation Of Post-translational Protein Modification
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Cellular Response To Stress
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Regulation Of Protein Metabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination
Positive Regulation Of Proteolysis
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
Autophagy
Positive Regulation Of Proteasomal Protein Catabolic Process
Enzyme Binding
Protein K63-linked Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Purine Nucleotide Metabolic Process
Response To Stress
Ubiquitin Protein Ligase Activity
Nucleus
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Mitophagy
Macroautophagy
Regulation Of Programmed Cell Death
Protein Autoubiquitination
Post-translational Protein Modification
Cysteine-type Deubiquitinase Activity
Protein Modification By Small Protein Removal
Protein Deubiquitination
Cysteine-type Peptidase Activity
Protein Binding
Sarcomere Organization
Protein Modification By Small Protein Conjugation
Protein Modification Process
Structural Constituent Of Muscle
Troponin Complex
Nucleus
Actomyosin Structure Organization
Striated Muscle Contraction
Z Disc
Cardiac Muscle Contraction
Ubiquitin Conjugating Enzyme Activity
Protein K48-linked Deubiquitination
Ubiquitin Protein Ligase Binding
Contractile Muscle Fiber
Sarcomere
Protein Ubiquitination
Troponin T Binding
Protein Metabolic Process
Myofibril
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Skeletal Muscle Contraction
Regulation Of DNA-templated Transcription
Negative Regulation Of DNA-templated Transcription
Deubiquitinase Activity
Proteolysis
Negative Regulation Of RNA Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
TORC1 Signaling
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
TOR Signaling
K48-linked Deubiquitinase Activity
Regulation Of Nucleobase-containing Compound Metabolic Process
Myofibril Assembly
Nucleoplasm
Cardiac Muscle Tissue Morphogenesis
Negative Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Muscle Contraction
Cytosol
Titin Binding
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Tagcloud (Intersection)
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