ATXN3 and RAD23B

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
HPRD (two hybrid, in vivo)

		ATXN3	RAD23B
Gene Name		ataxin 3	RAD23 homolog B (S. cerevisiae)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Nuclear Matrix Mitochondrial Membrane Nuclear Inclusion Body	Proteasome Complex Nucleus Nucleoplasm Cytoplasm XPC Complex
	Molecular Function	Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding ATPase Binding Lys63-specific Deubiquitinase Activity Lys48-specific Deubiquitinase Activity	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Polyubiquitin Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleotide-excision Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Misfolded Or Incompletely Synthesized Protein Catabolic Process Synaptic Transmission Nervous System Development Regulation Of Cell-substrate Adhesion Actin Cytoskeleton Organization Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Misfolded Protein	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Spermatogenesis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER DNA Damage Recognition in GG-NER Dual incision reaction in GG-NER
Drugs
Diseases
GWAS		Height ( 18391950 18391951) Orofacial clefts ( 22419666)	Body mass index ( 20966902) Breast cancer ( 21263130) Prostate cancer ( 23023329)
Protein-Protein Interactions		43 interactors: ANXA7 APP ARHGAP19 ARHGDIA ASIC1 C16orf70 CASP1 CDKN1A CSNK2B DNM2 EWSR1 GSK3B HDAC6 KAT2B MKNK1 NCOR1 PARK2 PICK1 PJA1 PSMD7 RAD23A RAD23B RFFL RPS6KA1 SQSTM1 STUB1 SUMO1 TEX11 TK1 TRAF6 TRIM54 TRIM55 TRIM63 TUBA1A TUBB UBB UBC UBE2L3 UBE2S UBE4B UBQLN1 USP21 VCP	20 interactors: ADRM1 ATXN3 CALM1 DBI DEAF1 HMGB1 MLH1 MPG NGLY1 PAX3 PNMA5 PSMD4 PUF60 RPA1 TDG UBA2 UBB UBE3A XPC ZFAND5
Entrez ID		4287	5887
HPRD ID		06131	06772
Ensembl ID		ENSG00000066427	ENSG00000119318
Uniprot IDs		P54252	B7Z4W4 P54727
PDB IDs		1YZB 2AGA 2DOS 2JRI 2KLZ	1P1A 1PVE 1UEL
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Proteolysis Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Macromolecule Catabolic Process Protein Ubiquitination Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Regulation Of Catalytic Activity Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Metabolic Process Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Abiotic Stimulus Cellular Response To Stress Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Cell Death Catabolic Process Response To Growth Factor Protein Metabolic Process Regulation Of Metabolic Process Apoptotic Process Programmed Cell Death Regulation Of Apoptotic Process Cell Death Death Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process	Cellular Macromolecule Catabolic Process Catabolic Process Cellular Response To DNA Damage Stimulus DNA Repair DNA Catabolic Process Base-excision Repair DNA Metabolic Process Nitrogen Compound Metabolic Process Aromatic Compound Catabolic Process Cellular Response To Stress Response To Stress Cellular Nitrogen Compound Metabolic Process Protein Catabolic Process Mismatch Repair Cellular Metabolic Process Base-excision Repair, AP Site Formation Modification-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Nucleotide-excision Repair Mitotic DNA Damage Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Mitotic DNA Integrity Checkpoint Multicellular Organismal Development Positive Regulation Of Proteolysis Heterocycle Metabolic Process Deoxyribose Phosphate Catabolic Process Cellular Aromatic Compound Metabolic Process Apoptotic Process Nucleotide-excision Repair, DNA Damage Removal Anatomical Structure Development Programmed Cell Death System Development Cell Death Death Negative Regulation Of Cellular Metabolic Process Regulation Of Proteolysis Response To Abiotic Stimulus Deoxyribonucleotide Catabolic Process DNA Damage Checkpoint Nervous System Development G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Protein Polyubiquitination Developmental Process Behavioral Fear Response Fear Response Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle Process
Tagcloud ?		14q32 amplifies ataxia atm atnx3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless pnkp polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable	a3 adoptive bioinformatic blunting dige diploid disulfide excision galactosidase hnrnpa3 hnrnpq imr90 isomerase lesser mir mirrored pdia3 permanent perturbation proteome ribonucleoprotein senescence senescent slowed synaptotagmin syncrip untranslated utrs
Tagcloud (Difference) ?		14q32 amplifies ataxia atm atnx3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless pnkp polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable	a3 adoptive bioinformatic blunting dige diploid disulfide excision galactosidase hnrnpa3 hnrnpq imr90 isomerase lesser mir mirrored pdia3 permanent perturbation proteome ribonucleoprotein senescence senescent slowed synaptotagmin syncrip untranslated utrs
Tagcloud (Intersection) ?