ATXN3 and CAPN1

Number of citations of the paper that reports this interaction (PubMedID 28334907)
0

Data Source:
BioGRID (unspecified method)

		ATXN3	CAPN1
Description		ataxin 3	calpain 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Matrix Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Nuclear Matrix Mitochondrial Membrane Nuclear Inclusion Body Synapse	Cornified Envelope Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Calpain Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding ATPase Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Cytoplasmic Translation Nucleotide-excision Repair Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Chemical Synaptic Transmission Nervous System Development Cellular Response To Starvation Regulation Of Cell-substrate Adhesion Protein Deubiquitination Actin Cytoskeleton Organization Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Exploration Behavior TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Misfolded Protein Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of ERAD Pathway Protein Localization To Cytosolic Proteasome Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Receptor Catabolic Process Regulation Of Catalytic Activity Mammary Gland Involution Self Proteolysis NMDA Selective Glutamate Receptor Signaling Pathway
Pathways		Josephin domain DUBs FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Amyotrophic lateral sclerosis ( 29566793) Coronary artery calcification ( 23870195) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 18391950 18391951) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Orofacial clefts ( 22419666) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)	Urate levels ( 31578528)
Interacting Genes		55 interacting genes: ANXA7 APP ARHGAP19 ARHGDIA ASIC1 CAPN1 CAPN2 CASP1 CDKN1A CHEK1 CSNK2B DNM2 EWSR1 GABARAP GSK3B KAT2B KPNA2 MAP1LC3A MAP1LC3C MAP3K1 MKNK1 NCOR1 NEDD8 PHAF1 PICK1 PRKN PSMD7 RAD23A RAD23B RFFL RPS6KA1 SMURF1 SQSTM1 STUB1 SUMO1 TEX11 TK1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TUBA1A TUBB UBB UBC UBE2D3 UBE2L3 UBE2S UBE2W UBE4B UBQLN1 USP21 VCP WWP2	55 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KCTD7 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM
Entrez ID		4287	823
HPRD ID		06131	00253
Ensembl ID		ENSG00000066427	ENSG00000014216
Uniprot IDs		A0A0A0MS38 C9JQV6 P54252	B2RDI5 B4DWH5 P07384
PDB IDs		1YZB 2AGA 2DOS 2JRI 2KLZ 4WTH 4YS9	1ZCM 2ARY 7W7O 7X79 8GX3
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cytosol Post-translational Protein Modification Cytoplasm Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Catabolic Process Regulation Of Proteolysis Macromolecule Metabolic Process Protein Polyubiquitination Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Autophagy Positive Regulation Of Proteasomal Protein Catabolic Process Enzyme Binding Protein K63-linked Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Response To Stress Ubiquitin Protein Ligase Activity Nucleus Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Mitophagy Macroautophagy Regulation Of Programmed Cell Death Protein Autoubiquitination	Organelle Organization Regulation Of Programmed Cell Death Response To Alcohol Regulation Of Organelle Organization Regulation Of Apoptotic Process Identical Protein Binding Positive Regulation Of Organelle Organization Regulation Of Multicellular Organismal Process Protease Binding Cytoplasm Regulation Of Signal Transduction Regulation Of Cellular Component Organization Developmental Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Amino Acid Stimulus Positive Regulation Of Gene Expression Response To Lipid Positive Regulation Of Programmed Cell Death Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Hepatocyte Apoptotic Process Cytosol Regulation Of Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Cell Junction Maintenance Regulation Of Renin Secretion Into Blood Stream Regulation Of Autophagy Sarcomere Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Mitochondrial Membrane Permeability G-protein Beta-subunit Binding Regulation Of Protein Localization Response To Amino Acid Release Of Cytochrome C From Mitochondria Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Fluoride Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Apoptotic Process Cellular Component Maintenance Regulation Of Membrane Permeability Cysteine-type Peptidase Activity Positive Regulation Of Cellular Component Organization Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Protein Localization
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