ATXN3 and UBE2S

Number of citations of the paper that reports this interaction (PubMedID 20622874)
50

Data Source:
BioGRID (enzymatic study)

		ATXN3	UBE2S
Description		ataxin 3	ubiquitin conjugating enzyme E2 S
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Matrix Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Nuclear Matrix Mitochondrial Membrane Nuclear Inclusion Body Synapse	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding ATPase Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Anaphase-promoting Complex Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Microtubule Cytoskeleton Organization Cytoplasmic Translation Nucleotide-excision Repair Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Chemical Synaptic Transmission Nervous System Development Cellular Response To Starvation Regulation Of Cell-substrate Adhesion Protein Deubiquitination Actin Cytoskeleton Organization Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Exploration Behavior TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Misfolded Protein Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of ERAD Pathway Protein Localization To Cytosolic Proteasome Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein K29-linked Ubiquitination Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K27-linked Ubiquitination Cell Division Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Josephin domain DUBs FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Amyotrophic lateral sclerosis ( 29566793) Coronary artery calcification ( 23870195) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 18391950 18391951) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Orofacial clefts ( 22419666) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		55 interacting genes: ANXA7 APP ARHGAP19 ARHGDIA ASIC1 CAPN1 CAPN2 CASP1 CDKN1A CHEK1 CSNK2B DNM2 EWSR1 GABARAP GSK3B KAT2B KPNA2 MAP1LC3A MAP1LC3C MAP3K1 MKNK1 NCOR1 NEDD8 PHAF1 PICK1 PRKN PSMD7 RAD23A RAD23B RFFL RPS6KA1 SMURF1 SQSTM1 STUB1 SUMO1 TEX11 TK1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TUBA1A TUBB UBB UBC UBE2D3 UBE2L3 UBE2S UBE2W UBE4B UBQLN1 USP21 VCP WWP2	33 interacting genes: AKT1 ANAPC1 ANAPC11 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CYLD HECTD3 HERC1 LINC00839 MDM2 NFKBIA OTUB1 OTUD7B PRKN RBCK1 STAMBP UBA1 UBA6 UBB UBC UCHL3 USP2 USP21 USP5 USP7
Entrez ID		4287	27338
HPRD ID		06131	15603
Ensembl ID		ENSG00000066427	ENSG00000108106
Uniprot IDs		A0A0A0MS38 C9JQV6 P54252	Q16763
PDB IDs		1YZB 2AGA 2DOS 2JRI 2KLZ 4WTH 4YS9	1ZDN 5BNB 5L9T 6QH3 6QHK 6S96 6S98 7AHF 8TAU
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cytosol Post-translational Protein Modification Cytoplasm Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Catabolic Process Regulation Of Proteolysis Macromolecule Metabolic Process Protein Polyubiquitination Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Autophagy Positive Regulation Of Proteasomal Protein Catabolic Process Enzyme Binding Protein K63-linked Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Response To Stress Ubiquitin Protein Ligase Activity Nucleus Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Mitophagy Macroautophagy Regulation Of Programmed Cell Death Protein Autoubiquitination	Post-translational Protein Modification Proteolysis Protein Modification Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Protein Deubiquitination Proteasomal Protein Catabolic Process Protein Modification By Small Protein Removal Protein Catabolic Process Protein Branched Polyubiquitination Protein Polyubiquitination Macromolecule Metabolic Process Catabolic Process Regulation Of Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Cysteine-type Deubiquitinase Activity Protein K48-linked Ubiquitination Regulation Of Sister Chromatid Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Cytosol Positive Regulation Of Mitotic Sister Chromatid Separation Cysteine-type Peptidase Activity Regulation Of Chromosome Segregation Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Chromosome Organization Positive Regulation Of Chromosome Separation Positive Regulation Of Cell Cycle Phase Transition Regulation Of Reproductive Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Metaphase/anaphase Transition Of Cell Cycle Ubiquitin Binding Ubiquitin-protein Transferase Activity Regulation Of Mitotic Sister Chromatid Separation Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Separation Peptidase Activity Regulation Of Mitotic Cell Cycle Phase Transition
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