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ATXN3 and TUBA1A
Number of citations of the paper that reports this interaction (PubMedID
24685680
)
0
Data Source:
BioGRID
(pull down)
ATXN3
TUBA1A
Description
ataxin 3
tubulin alpha 1a
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrial Matrix
Lysosome
Lysosomal Membrane
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Membrane
Nuclear Matrix
Mitochondrial Membrane
Nuclear Inclusion Body
Synapse
Condensed Chromosome
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Microtubule
Axonemal Microtubule
Cytoplasmic Microtubule
Plasma Membrane
Cilium
Microtubule Cytoskeleton
Motile Cilium
Neuromuscular Junction
Sperm Flagellum
Cytoplasmic Ribonucleoprotein Granule
Cell Projection
Synapse
Recycling Endosome
Extracellular Exosome
Molecular Function
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
ATPase Binding
K63-linked Deubiquitinase Activity
K48-linked Deubiquitinase Activity
Nucleotide Binding
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
GTP Binding
Hydrolase Activity
Identical Protein Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
Biological Process
Microtubule Cytoskeleton Organization
Cytoplasmic Translation
Nucleotide-excision Repair
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Chemical Synaptic Transmission
Nervous System Development
Cellular Response To Starvation
Regulation Of Cell-substrate Adhesion
Protein Deubiquitination
Actin Cytoskeleton Organization
Cellular Response To Nutrient Levels
Cellular Response To Amino Acid Starvation
Cellular Response To Heat
Monoubiquitinated Protein Deubiquitination
Exploration Behavior
TORC1 Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Intermediate Filament Cytoskeleton Organization
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Cellular Response To Misfolded Protein
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Positive Regulation Of ERAD Pathway
Protein Localization To Cytosolic Proteasome Complex
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Neuron Migration
Startle Response
Intracellular Protein Transport
Microtubule-based Process
Centrosome Cycle
Smoothened Signaling Pathway
Memory
Locomotory Behavior
Adult Locomotory Behavior
Visual Learning
Response To Mechanical Stimulus
Glial Cell Differentiation
Gene Expression
Dentate Gyrus Development
Cerebellar Cortex Morphogenesis
Hippocampus Development
Pyramidal Neuron Differentiation
Cerebral Cortex Development
Neurogenesis
Neuron Differentiation
Flagellated Sperm Motility
Adult Behavior
Cytoskeleton-dependent Intracellular Transport
Response To Tumor Necrosis Factor
Locomotory Exploration Behavior
Microtubule Polymerization
Forebrain Morphogenesis
Homeostasis Of Number Of Cells Within A Tissue
Regulation Of Synapse Organization
Synapse Organization
Cell Division
Neuron Apoptotic Process
Motor Behavior
Cellular Response To Calcium Ion
Organelle Transport Along Microtubule
Neuron Projection Arborization
Response To L-glutamate
Pathways
Josephin domain DUBs
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Recycling pathway of L1
Hedgehog 'off' state
Anchoring of the basal body to the plasma membrane
Cargo trafficking to the periciliary membrane
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Carboxyterminal post-translational modifications of tubulin
Carboxyterminal post-translational modifications of tubulin
HCMV Early Events
Assembly and cell surface presentation of NMDA receptors
Activation of AMPK downstream of NMDARs
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Sealing of the nuclear envelope (NE) by ESCRT-III
Kinesins
PKR-mediated signaling
Drugs
Albendazole
Vinblastine
Mebendazole
Epothilone D
Patupilone
CYT997
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Artenimol
Phenethyl Isothiocyanate
Colchiceine
Diseases
Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS
Amyotrophic lateral sclerosis (
29566793
)
Coronary artery calcification (
23870195
)
HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction (
31806883
)
Height (
18391950
18391951
)
Hip circumference adjusted for BMI (
34021172
)
LDL cholesterol levels x loop diuretics use interaction (
31806883
)
Orofacial clefts (
22419666
)
Refractive error (
32231278
)
Waist circumference adjusted for body mass index (
34021172
)
Brain morphology (MOSTest) (
32665545
)
Composite immunoglobulin trait (IgG/IgM) (
28628107
)
Interacting Genes
55 interacting genes:
ANXA7
APP
ARHGAP19
ARHGDIA
ASIC1
CAPN1
CAPN2
CASP1
CDKN1A
CHEK1
CSNK2B
DNM2
EWSR1
GABARAP
GSK3B
KAT2B
KPNA2
MAP1LC3A
MAP1LC3C
MAP3K1
MKNK1
NCOR1
NEDD8
PHAF1
PICK1
PRKN
PSMD7
RAD23A
RAD23B
RFFL
RPS6KA1
SMURF1
SQSTM1
STUB1
SUMO1
TEX11
TK1
TP53
TRAF6
TRIM54
TRIM55
TRIM63
TUBA1A
TUBB
UBB
UBC
UBE2D3
UBE2L3
UBE2S
UBE2W
UBE4B
UBQLN1
USP21
VCP
WWP2
66 interacting genes:
ANXA7
ARL3
ATXN3
B4GALT1
BTG1
C8orf33
CDKN1A
CDKN2A
CEP20
CLIP1
CNP
CPEB2
CXCR1
CYLD
DAG1
DUSP23
EGFR
EIF4ENIF1
EML1
ENO1
GEMIN7
GRM7
GSK3B
GZMB
HTRA2
KEL
KPNB1
LINC01554
LRRK2
MAP7D3
MAPK6
MAPRE1
MAX
MX1
MYC
NFATC1
NUDT3
OGT
PAFAH1B1
PGK1
PLA2G7
PLK2
S100A8
S100A9
SDC3
SIAH1
SMN1
SNCA
SOCS6
SOCS7
SPART
STARD13
STK11
SYK
SYTL4
TAOK2
TIMM17A
TK1
TLN1
TTR
TUBB
UBE2D3
VAV1
VCL
YWHAQ
ZAP70
Entrez ID
4287
7846
HPRD ID
06131
03959
Ensembl ID
ENSG00000066427
ENSG00000167552
Uniprot IDs
A0A0A0MS38
C9JQV6
P54252
Q71U36
PDB IDs
1YZB
2AGA
2DOS
2JRI
2KLZ
4WTH
4YS9
5JCO
6J8F
6WSL
7C1M
7UN1
7UNG
8J07
8SH7
Enriched GO Terms of Interacting Partners
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Ubiquitin Protein Ligase Binding
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Protein Modification Process
Protein Metabolic Process
Macromolecule Catabolic Process
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Cytosol
Post-translational Protein Modification
Cytoplasm
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Protein Catabolic Process
Regulation Of Proteolysis
Macromolecule Metabolic Process
Protein Polyubiquitination
Positive Regulation Of Post-translational Protein Modification
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Cellular Response To Stress
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Regulation Of Protein Metabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Ubiquitination
Positive Regulation Of Proteolysis
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
Autophagy
Positive Regulation Of Proteasomal Protein Catabolic Process
Enzyme Binding
Protein K63-linked Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Purine Nucleotide Metabolic Process
Response To Stress
Ubiquitin Protein Ligase Activity
Nucleus
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Mitophagy
Macroautophagy
Regulation Of Programmed Cell Death
Protein Autoubiquitination
Cytoplasm
Cytosol
Regulation Of Cell Growth
Intracellular Signaling Cassette
Microtubule Binding
Regulation Of Growth
Microtubule Cytoskeleton Organization
Intracellular Signal Transduction
Regulation Of Cellular Component Organization
Organelle Organization
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Programmed Cell Death
Protein-containing Complex
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Cytoskeleton
Positive Regulation Of Cell Communication
Regulation Of Cell Communication
Kinase Activity
Positive Regulation Of Signaling
Regulation Of Signaling
Protein Metabolic Process
Regulation Of Developmental Process
Regulation Of Intrinsic Apoptotic Signaling Pathway
Myeloid Leukocyte Migration
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Cell Migration
Neutrophil Chemotaxis
Developmental Process
Cytoplasmic Microtubule
Microtubule-based Process
Ubiquitin Protein Ligase Binding
Catabolic Process
Leukocyte Migration
Protein Serine/threonine Kinase Activity
Protein Kinase Activity
Tubulin Binding
Negative Regulation Of Cell Growth
Cytoskeleton Organization
Neutrophil Migration
Protein Localization To Nucleus
Cellular Developmental Process
Microtubule Cytoskeleton
Microtubule
Positive Regulation Of Apoptotic Process
Leukocyte Aggregation
Regulation Of Microtubule-based Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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