MIP and CRYAA

Number of citations of the paper that reports this interaction (PMID 8910261)
2

Data Source:
HPRD (in vitro)

		MIP	CRYAA
Gene Name		major intrinsic protein of lens fiber	crystallin, alpha A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Gap Junction Apical Plasma Membrane Intracellular Membrane-bounded Organelle Intracellular Canaliculus	Nucleus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Eye Lens Transporter Activity Calmodulin Binding Water Channel Activity Glycerol Channel Activity	Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Lens Development In Camera-type Eye Water Transport Visual Perception Cellular Water Homeostasis Canalicular Bile Acid Transport Glycerol Transport Ion Transmembrane Transport Response To Stimulus Transmembrane Transport	Visual Perception Negative Regulation Of Intracellular Transport Protein Refolding Negative Regulation Of Apoptotic Process Response To Stimulus Protein Homooligomerization
Pathways		Passive transport by Aquaporins Aquaporin-mediated transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CALM1 CRYAA CRYAB CRYBB2 CRYGC FOXA2 GJA3 GJA8 PRKACA	17 interactors: ALB BCL2L1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS GORASP2 HSPB1 HSPB2 LALBA MIP SDCBP SPG21 WDYHV1
Entrez ID		4284	1409
HPRD ID		01098	00427
Ensembl ID		ENSG00000135517	ENSG00000160202
Uniprot IDs		P30301	E9PHE4 P02489
PDB IDs
Enriched GO Terms of Interacting Partners?		Visual Perception Sensory Perception Of Light Stimulus Sensory Perception Camera-type Eye Development Negative Regulation Of Transport Eye Development Regulation Of Intracellular Transport Organ Development Cellular Response To Radiation Regulation Of Cellular Localization Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Neurological System Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Sensory Organ Development Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Protein Homooligomerization Positive Regulation Of Lyase Activity System Development Activation Of Phospholipase C Activity Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of CAMP Biosynthetic Process Cell-cell Signaling Regulation Of Cyclase Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of CAMP Metabolic Process Multicellular Organismal Development Positive Regulation Of Phospholipase Activity Regulation Of Heart Rate Negative Regulation Of Phosphorylation Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Phototransduction, Visible Light Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Detection Of Glucose Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Phospholipase Activity Protein Oligomerization Regulation Of Striated Muscle Contraction Regulation Of CAMP Biosynthetic Process	Visual Perception Sensory Perception Of Light Stimulus Camera-type Eye Development Eye Development Lens Development In Camera-type Eye Sensory Organ Development Sensory Perception Cellular Response To Gamma Radiation Neurological System Process Bile Acid And Bile Salt Transport Response To Gamma Radiation Cellular Response To Ionizing Radiation Apoptotic Process In Bone Marrow Retina Homeostasis Maintenance Of Mitochondrion Location Lactose Biosynthetic Process Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Stimulus Interaction With Host Organ Development Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Suppression By Virus Of Host Apoptotic Process Anatomical Structure Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Disaccharide Metabolic Process Canalicular Bile Acid Transport Positive Regulation Of Behavior Monocarboxylic Acid Transport Response To Unfolded Protein Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Cell Death Cellular Response To Radiation System Development Response To Ionizing Radiation Protein Processing Involved In Protein Targeting To Mitochondrion Response To Cycloheximide Cellular Process Regulating Host Cell Cycle In Response To Virus Mitochondrial Transport Regulation Of Intrinsic Apoptotic Signaling Pathway Tubulin Complex Assembly Positive Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Stress
Tagcloud ?		7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2	aiims beaded bfsp1 cataract congenital cryab cryba1 cryba4 crybb1 crybb2 crybb3 crygs crystallin cx d85n delhi e155k e75k expands filament fourteen gja3 gja8 m1v ophthalmic sciences studio transparency y67n
Tagcloud (Difference) ?		7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2	aiims beaded bfsp1 cataract congenital cryab cryba1 cryba4 crybb1 crybb2 crybb3 crygs crystallin cx d85n delhi e155k e75k expands filament fourteen gja3 gja8 m1v ophthalmic sciences studio transparency y67n
Tagcloud (Intersection) ?