MIP and CRYBB2

Number of citations of the paper that reports this interaction (PubMedID 18004741)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MIP	CRYBB2
Description		major intrinsic protein of lens fiber	crystallin beta B2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Anchoring Junction
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Calmodulin Binding Water Channel Activity Channel Activity Cell Adhesion Mediator Activity	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding
	Biological Process	Lens Development In Camera-type Eye Water Transport Visual Perception Homotypic Cell-cell Adhesion Maintenance Of Lens Transparency Transmembrane Transport Gap Junction-mediated Intercellular Transport	Lens Development In Camera-type Eye Visual Perception Camera-type Eye Development
Pathways		Passive transport by Aquaporins
Drugs		B-nonylglucoside
Diseases
GWAS		Axial length ( 24144296) Lipoprotein (a) levels ( 33730874) Serum metabolite levels ( 33031748)	Adverse response to drug ( 30420678)
Interacting Genes		48 interacting genes: AQP6 AQP9 ATP6V0B CALM1 CD40 CISD2 CLDN5 CRYAA CRYAB CRYBB2 CRYGC ERGIC3 ERVFRD-1 FAM209A FCGR2A FOXA2 GJA3 GJA8 GJB5 GOLM1 GPX8 KCNJ6 LHFPL5 LMNA LRRC4C MFF MGST3 MRM3 MRPS18B MUC1 PDZK1IP1 PRKACA RELL2 SAR1A SGPL1 SLC14A1 SLC18A1 SSMEM1 STX1A STX2 SYAP1 SYT1 SYT2 TMEM139 TMEM154 TMEM52B TMX2 ZFPL1	9 interacting genes: CRYAA CRYAB CRYBA1 CRYBA2 CRYBA4 CRYGC HSPB1 LMO4 MIP
Entrez ID		4284	1415
HPRD ID		01098	00430
Ensembl ID		ENSG00000135517	ENSG00000244752
Uniprot IDs		P30301	P43320 R4UMM2
PDB IDs			1YTQ 7K7U
Enriched GO Terms of Interacting Partners?		Membrane Lens Development In Camera-type Eye Structural Constituent Of Eye Lens Structural Molecule Activity Urea Channel Activity Gap Junction Channel Activity Connexin Complex SNARE Binding Synaptic Vesicle Membrane One-carbon Compound Transport Water Transport Gap Junction Calcium-dependent Protein Binding Organelle Localization By Membrane Tethering Clathrin-sculpted Monoamine Transport Vesicle Membrane Urea Transmembrane Transporter Activity Membrane Docking Camera-type Eye Development Gap Junction-mediated Intercellular Transport Fluid Transport Plasma Membrane Protein Binding Regulation Of Calcium Ion-dependent Exocytosis Chromaffin Granule Membrane Urea Transmembrane Transport Tubulin Complex Assembly Intercellular Transport Amine Transport Urea Transport Modulation Of Chemical Synaptic Transmission Eye Development Positive Regulation Of Catecholamine Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion Water Channel Activity Calcium Channel Inhibitor Activity Vesicle Docking Detection Of Calcium Ion Positive Regulation Of Calcium Ion-dependent Exocytosis Dense Core Granule Calcium Ion Sensor Activity Voltage-gated Potassium Channel Complex Sensory Organ Development Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Dendrite Extension Positive Regulation Of Vesicle Fusion Glutathione Peroxidase Activity	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Visual Perception Sensory Perception Of Light Stimulus Sensory Perception Protein Refolding System Process Nervous System Process Tubulin Complex Assembly Response To Heat Camera-type Eye Development Contractile Muscle Fiber Unfolded Protein Binding Eye Development Response To Temperature Stimulus Apoptotic Process Involved In Morphogenesis Sensory Organ Development Apoptotic Process Involved In Development Protein Folding Negative Regulation Of Intracellular Transport Developmental Process Homotypic Cell-cell Adhesion Negative Regulation Of Protein Kinase C Signaling Identical Protein Binding Response To Hydrogen Peroxide Protein Kinase C Inhibitor Activity Ventral Spinal Cord Interneuron Differentiation Negative Regulation Of Protein-containing Complex Assembly Z Disc Regulation Of Protein Kinase C Signaling Response To Reactive Oxygen Species Gap Junction-mediated Intercellular Transport Structural Molecule Activity Lens Fiber Cell Morphogenesis Cardiac Myofibril Positive Regulation Of Anoikis Spinal Cord Motor Neuron Cell Fate Specification Regulation Of Apoptotic Process Animal Organ Development Maintenance Of Lens Transparency Actin Filament Bundle Anterograde Axonal Protein Transport Regulation Of Programmed Cell Death Intercellular Transport Spinal Cord Association Neuron Differentiation
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