MIP and FOXA2

Number of citations of the paper that reports this interaction (PMID 12642491)
13

Data Source:
HPRD (in vitro)

		MIP	FOXA2
Gene Name		major intrinsic protein of lens fiber	forkhead box A2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Gap Junction Apical Plasma Membrane Intracellular Membrane-bounded Organelle Intracellular Canaliculus	Nucleus Cytoplasm
	Molecular Function	Structural Constituent Of Eye Lens Transporter Activity Calmodulin Binding Water Channel Activity Glycerol Channel Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Domain Specific Binding Transcription Regulatory Region DNA Binding
	Biological Process	Lens Development In Camera-type Eye Water Transport Visual Perception Cellular Water Homeostasis Canalicular Bile Acid Transport Glycerol Transport Ion Transmembrane Transport Response To Stimulus Transmembrane Transport	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Negative Regulation Of Transcription From RNA Polymerase II Promoter By Glucose In Utero Embryonic Development Ectoderm Formation Cell Fate Specification Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Adult Locomotory Behavior Negative Regulation Of Epithelial To Mesenchymal Transition Chromatin Modification Regulation Of Steroid Metabolic Process Cell Differentiation In Hindbrain Dorsal/ventral Neural Tube Patterning Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Blood Coagulation Endocrine Pancreas Development Somite Rostral/caudal Axis Specification Negative Regulation Of Glucokinase Activity Positive Regulation Of Embryonic Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Cell Development Neuron Fate Specification Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Connective Tissue Development Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation Negative Regulation Of Detection Of Glucose
Pathways		Passive transport by Aquaporins Aquaporin-mediated transport	Regulation of beta-cell development Regulation of gene expression in beta cells
Drugs
Diseases
GWAS			Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 20152958) Male-pattern baldness ( 22693459)
Protein-Protein Interactions		9 interactors: CALM1 CRYAA CRYAB CRYBB2 CRYGC FOXA2 GJA3 GJA8 PRKACA	9 interactors: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTX2 TLE1
Entrez ID		4284	3170
HPRD ID		01098	02618
Ensembl ID		ENSG00000135517	ENSG00000125798
Uniprot IDs		P30301	B0ZTD4 Q9Y261
PDB IDs
Enriched GO Terms of Interacting Partners?		Visual Perception Sensory Perception Of Light Stimulus Sensory Perception Camera-type Eye Development Negative Regulation Of Transport Eye Development Regulation Of Intracellular Transport Organ Development Cellular Response To Radiation Regulation Of Cellular Localization Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Neurological System Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Sensory Organ Development Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Protein Homooligomerization Positive Regulation Of Lyase Activity System Development Activation Of Phospholipase C Activity Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of CAMP Biosynthetic Process Cell-cell Signaling Regulation Of Cyclase Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of CAMP Metabolic Process Multicellular Organismal Development Positive Regulation Of Phospholipase Activity Regulation Of Heart Rate Negative Regulation Of Phosphorylation Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Phototransduction, Visible Light Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Detection Of Glucose Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Phospholipase Activity Protein Oligomerization Regulation Of Striated Muscle Contraction Regulation Of CAMP Biosynthetic Process	Organ Development Positive Regulation Of Gene Expression System Development Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Hindbrain Development Embryonic Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Embryonic Morphogenesis Developmental Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Endoderm Development Embryonic Organ Morphogenesis Brain Development Chordate Embryonic Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gastrulation Embryo Development Ending In Birth Or Egg Hatching Head Development Positive Regulation Of Cellular Biosynthetic Process Primitive Streak Formation Dorsal/ventral Pattern Formation Embryonic Skeletal System Morphogenesis Metencephalon Development Central Nervous System Development Somite Rostral/caudal Axis Specification Cell Development Forebrain Development Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Pattern Specification Process Epithelium Development RNA Metabolic Process Embryonic Skeletal System Development Embryo Development Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Gastrulation
Tagcloud ?		7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2	acetylated battery brachyury confocal deta differentiating directed disrupting endoderm express flk1 gata4 matter mef2c mesc mesendoderm mesoderm mesodermal nanog occupancy oct4 pluripotency protocols reexpressed reexpression repression resp simultaneously undergoing
Tagcloud (Difference) ?		7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2	acetylated battery brachyury confocal deta differentiating directed disrupting endoderm express flk1 gata4 matter mef2c mesc mesendoderm mesoderm mesodermal nanog occupancy oct4 pluripotency protocols reexpressed reexpression repression resp simultaneously undergoing
Tagcloud (Intersection) ?