ERBB2IP and ACTN2

Number of citations of the paper that reports this interaction (PMID 15123239)
9

Data Source:
BioGRID (unspecified method)

		ERBB2IP	ACTN2
Gene Name		erbb2 interacting protein	actinin, alpha 2
Image
Gene Ontology Annotations	Cellular Component	Basement Membrane Nucleus Nucleoplasm Cytoplasm Plasma Membrane Basal Plasma Membrane Cell Junction Hemidesmosome Nuclear Membrane	Extracellular Region Cytosol Cytoskeleton Actin Filament Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	ErbB-2 Class Receptor Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding	Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle LIM Domain Binding Thyroid Hormone Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Protein Dimerization Activity Actin Filament Binding FATZ Binding Titin Z Domain Binding
	Biological Process	Protein Targeting Cell Cycle Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Growth Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity	Platelet Degranulation Cell Adhesion Synaptic Transmission Blood Coagulation Microspike Assembly Muscle Filament Sliding Platelet Activation Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Focal Adhesion Assembly Protein Homotetramerization Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Receptor Activity
Pathways		Signaling by ERBB2	Striated Muscle Contraction Platelet degranulation CREB phosphorylation through the activation of Ras Activation of NMDA receptor upon glutamate binding and postsynaptic events Response to elevated platelet cytosolic Ca2+ CREB phosphorylation through the activation of CaMKII Nephrin interactions Platelet activation, signaling and aggregation Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS
Protein-Protein Interactions		62 interactors: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 NOD2 NR2E1 PICK1 PKP4 RAF1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9	59 interactors: ACTN3 ADAM12 ADORA2A ANG ATXN2 ATXN7 BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 COIL DISC1 DLG1 DLG4 EPS8L1 ERBB2IP FAM154A FBXL22 GRIN1 GRIN2B ITGB3BP KAT2B KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MED14 MICALL2 MOS MYOZ1 MYOZ2 MYOZ3 MYPN NCOA2 NCOR1 NOS3 NR1I2 NRIP1 PALLD PDLIM1 PDLIM3 PKD2 RAVER1 RPL35 RTP5 SELE SNAI1 SNW1 SP100 SSX2IP ST7 SYNPO2 TNN TTN UTRN ZNF446
Entrez ID		55914	88
HPRD ID		06090	00019
Ensembl ID		ENSG00000112851	ENSG00000077522
Uniprot IDs		B4DIP2 Q96RT1	B2RCS5 P35609 Q59FD9
PDB IDs		1MFG 1MFL 1N7T 2H3L 2QBW 3CH8	1H8B 1HCI 1QUU
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Response To Stimulus Response To Organic Substance Signaling Cellular Response To Growth Factor Stimulus Cell Communication Response To Growth Factor Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Response To Stress Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Positive Regulation Of Cellular Biosynthetic Process Cell Junction Assembly Regulation Of Cell Proliferation SMAD Protein Complex Assembly Negative Regulation Of Cell Proliferation Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Movement Signal Transduction Cellular Response To Organic Cyclic Compound Organ Development Anatomical Structure Morphogenesis Cellular Component Assembly Cell-cell Junction Organization Positive Regulation Of Transcription, DNA-templated Renal System Development Negative Regulation Of Signaling Regulation Of Cell Motility Gastrulation Cell-cell Signaling Regulation Of Cell Differentiation Negative Regulation Of Signal Transduction Regulation Of Locomotion Response To Wounding Urogenital System Development Regulation Of Cell Migration System Development Regulation Of Epithelial Cell Proliferation Adherens Junction Organization Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Positive Regulation Of Gene Expression Response To Organic Cyclic Compound Neurotrophin TRK Receptor Signaling Pathway	Cytoskeleton Organization Regulation Of Ion Transport Organelle Organization Cell Communication Actin Filament-based Process Signaling Cellular Component Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Ion Transmembrane Transport Anatomical Structure Development Synaptic Transmission Positive Regulation Of Metabolic Process Cell Development Signal Transduction Movement Of Cell Or Subcellular Component Cell Differentiation Cell-cell Signaling Regulation Of Cellular Process Rhythmic Process Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Actin Cytoskeleton Organization Anatomical Structure Morphogenesis Protein Complex Assembly Regulation Of Potassium Ion Transport Striated Muscle Cell Differentiation Regulation Of Signaling Anatomical Structure Formation Involved In Morphogenesis Response To Organic Substance Regulation Of Sodium Ion Transport Response To Abiotic Stimulus Muscle System Process Negative Regulation Of Transport Striated Muscle Cell Development Positive Regulation Of Cellular Biosynthetic Process Myofibril Assembly Establishment Or Maintenance Of Apical/basal Cell Polarity Transcription Initiation From RNA Polymerase II Promoter Cell Adhesion Muscle Cell Development Cellular Calcium Ion Homeostasis Regulation Of Receptor Internalization Regulation Of Cellular Response To Heat Response To Stimulus Regulation Of Histone Deacetylase Activity Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Locomotion Negative Regulation Of Ion Transport
Tagcloud ?		adoptive cd4 cholangiocarcinoma contained exists exomic experienced harnessed helper humans infiltrating interacting lymphocytes mediate metastatic mount mutated mutation polyfunctional prolonged pure recognizing regression retreated sequencing stabilization til transfer	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Difference) ?		adoptive cd4 cholangiocarcinoma contained exists exomic experienced harnessed helper humans infiltrating interacting lymphocytes mediate metastatic mount mutated mutation polyfunctional prolonged pure recognizing regression retreated sequencing stabilization til transfer	actinin barr cd99 cdk8 dnajb2 e2f e2f2 ebv epstein fatigue hsp40 hybridized indicative infectious infective irritability isg20 malaise microarrays mononucleosis oligonucleotides pbmc persist pilot recovered resolve somnolence spotted uneventfully
Tagcloud (Intersection) ?