ERBIN and NR2E1

Number of citations of the paper that reports this interaction (PubMedID 15123239)
0

Data Source:
BioGRID (unspecified method)

		ERBIN	NR2E1
Description		erbb2 interacting protein	nuclear receptor subfamily 2 group E member 1
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GO Annotations	Cellular Component	Basement Membrane Nucleus Cytoplasm Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Nuclear Speck Cell Junction Hemidesmosome Neuromuscular Junction Nuclear Membrane Anchoring Junction Postsynapse Glutamatergic Synapse Postsynaptic Specialization	Chromatin Nucleus Nucleoplasm
	Molecular Function	Signaling Receptor Binding ErbB-2 Class Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Targeting Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Gene Expression Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Response To Lipopolysaccharide Intracellular Signal Transduction Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Behavioral Fear Response Positive Regulation Of Neuroblast Proliferation Aggressive Behavior Regulation Of DNA-templated Transcription Apoptotic Process Nervous System Development Neuroblast Proliferation Brain Development Visual Perception Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Dentate Gyrus Development Amygdala Development Olfactory Bulb Development Layer Formation In Cerebral Cortex Forebrain Generation Of Neurons Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Differentiation Anterior Commissure Morphogenesis Cerebral Cortex Development Cell Differentiation Extracellular Matrix Organization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Social Behavior Camera-type Eye Development Negative Regulation Of Apoptotic Process Astrocyte Cell Migration Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Regulation Of Dendrite Morphogenesis Regulation Of Cellular Component Organization Retina Development In Camera-type Eye Regulation Of Timing Of Neuron Differentiation Long-term Synaptic Potentiation Neural Precursor Cell Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation
Pathways		Signaling by ERBB2 Downregulation of ERBB2 signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants	Nuclear Receptor transcription pathway Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		66 interacting genes: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 MUSK NOD2 NR2E1 PICK1 PKP4 RAF1 RBX1 RNF7 RPS6KA1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9	6 interacting genes: ATN1 DNMT3L ERBIN KDM1A NSD1 RERE
Entrez ID		55914	7101
HPRD ID		06090	07230
Ensembl ID		ENSG00000112851	ENSG00000112333
Uniprot IDs		A0A8V8TML4 A0A8V8TPC7 Q96RT1	B6ZGT9 Q9Y466
PDB IDs		1MFG 1MFL 1N7T 2H3L 2QBW 3CH8 6Q0M 6Q0N 6Q0U 6UBH 7LUL	4XAJ
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane I-SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Heteromeric SMAD Protein Complex Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Basolateral Plasma Membrane Cell Junction Organization Adherens Junction Trophoblast Cell Migration SMAD Protein Complex Regulation Of Signal Transduction Regulation Of System Process Gastrulation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway SMAD Protein Signal Transduction Embryonic Foregut Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anchoring Junction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Cell Junction Assembly Cell Junction Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Protein Kinase Binding Positive Regulation Of RNA Metabolic Process MAPK Cascade Cell-substrate Junction Assembly Response To Growth Factor Metal Ion Transport Transcription Regulator Complex Gastrulation With Mouth Forming Second Cell-substrate Junction Organization Positive Regulation Of Developmental Process Negative Regulation Of Developmental Process Negative Regulation Of Ossification Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Cell Projection Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation	Transcription Corepressor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Nuclear Androgen Receptor Binding Regulation Of Chromatin Organization Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Transcription Coactivator Activity Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Post-embryonic Development Regulation Of Nucleobase-containing Compound Metabolic Process Cerebellar Purkinje Cell Layer Maturation Chromatin Binding Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Basal Protein Localization Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Radial Glia Guided Migration Of Purkinje Cell Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Epigenetic Programing Of Female Pronucleus ErbB-2 Class Receptor Binding Positive Regulation Of Biosynthetic Process Protein Demethylase Activity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Histone H3K36 Dimethyltransferase Activity Establishment Or Maintenance Of Cell Polarity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Branching Morphogenesis Of A Nerve Platelet Dense Granule Membrane Response To Fungicide MRF Binding Guanine Metabolic Process Chorionic Trophoblast Cell Differentiation Autosome Genomic Imprinting Negative Regulation Of Heterochromatin Formation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Macromolecule Biosynthetic Process Methylation
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