ERBB2IP and NR2E1

Number of citations of the paper that reports this interaction (PMID 15123239)
9

Data Source:
BioGRID (unspecified method)

		ERBB2IP	NR2E1
Gene Name		erbb2 interacting protein	nuclear receptor subfamily 2, group E, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Basement Membrane Nucleus Nucleoplasm Cytoplasm Plasma Membrane Basal Plasma Membrane Cell Junction Hemidesmosome Nuclear Membrane	Nucleoplasm
	Molecular Function	ErbB-2 Class Receptor Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Steroid Hormone Receptor Activity Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding
	Biological Process	Protein Targeting Cell Cycle Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Growth Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Behavioral Fear Response Aggressive Behavior Transcription Initiation From RNA Polymerase II Promoter Nervous System Development Visual Perception Glial Cell Migration Gene Expression Dentate Gyrus Development Amygdala Development Olfactory Bulb Development Layer Formation In Cerebral Cortex Forebrain Generation Of Neurons Cerebral Cortex Neuron Differentiation Anterior Commissure Morphogenesis Extracellular Matrix Organization Somatic Stem Cell Maintenance Social Behavior Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Astrocyte Differentiation Regulation Of Dendrite Morphogenesis Retina Development In Camera-type Eye Regulation Of Timing Of Neuron Differentiation Long-term Synaptic Potentiation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation
Pathways		Signaling by ERBB2	Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		62 interactors: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 NOD2 NR2E1 PICK1 PKP4 RAF1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9	6 interactors: ATN1 BCL11A ERBB2IP KDM1A NSD1 RERE
Entrez ID		55914	7101
HPRD ID		06090	07230
Ensembl ID		ENSG00000112851	ENSG00000112333
Uniprot IDs		B4DIP2 Q96RT1	B6ZGT9 Q6ZMP8 Q9Y466
PDB IDs		1MFG 1MFL 1N7T 2H3L 2QBW 3CH8
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Response To Stimulus Response To Organic Substance Signaling Cellular Response To Growth Factor Stimulus Cell Communication Response To Growth Factor Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Response To Stress Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Positive Regulation Of Cellular Biosynthetic Process Cell Junction Assembly Regulation Of Cell Proliferation SMAD Protein Complex Assembly Negative Regulation Of Cell Proliferation Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Movement Signal Transduction Cellular Response To Organic Cyclic Compound Organ Development Anatomical Structure Morphogenesis Cellular Component Assembly Cell-cell Junction Organization Positive Regulation Of Transcription, DNA-templated Renal System Development Negative Regulation Of Signaling Regulation Of Cell Motility Gastrulation Cell-cell Signaling Regulation Of Cell Differentiation Negative Regulation Of Signal Transduction Regulation Of Locomotion Response To Wounding Urogenital System Development Regulation Of Cell Migration System Development Regulation Of Epithelial Cell Proliferation Adherens Junction Organization Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Positive Regulation Of Gene Expression Response To Organic Cyclic Compound Neurotrophin TRK Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of Primitive Erythrocyte Differentiation Chromatin Modification Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Basal Protein Localization Chromatin Organization Negative Regulation Of Cellular Metabolic Process Establishment Or Maintenance Of Cell Polarity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Homooligomerization Chromosome Organization Multicellular Organismal Development Negative Regulation Of Collateral Sprouting Peptidyl-lysine Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Protein Oligomerization Positive Regulation Of Megakaryocyte Differentiation Histone H3-K36 Methylation Leukocyte Differentiation Positive Regulation Of Collateral Sprouting Positive Regulation Of Hormone Biosynthetic Process Maintenance Of Cell Polarity Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Developmental Process
Tagcloud ?		adoptive cd4 cholangiocarcinoma contained exists exomic experienced harnessed helper humans infiltrating interacting lymphocytes mediate metastatic mount mutated mutation polyfunctional prolonged pure recognizing regression retreated sequencing stabilization til transfer	carcinogenesis cdkn1a doxorubicin druggable ectopic enhancement escape exact oncogene orphan overcoming perform potently premalignant prevent promoted prostate prostatic pten rasg12v repression senescence sirt1 suppressing tlx transactivation triggered tumour tumourigenesis
Tagcloud (Difference) ?		adoptive cd4 cholangiocarcinoma contained exists exomic experienced harnessed helper humans infiltrating interacting lymphocytes mediate metastatic mount mutated mutation polyfunctional prolonged pure recognizing regression retreated sequencing stabilization til transfer	carcinogenesis cdkn1a doxorubicin druggable ectopic enhancement escape exact oncogene orphan overcoming perform potently premalignant prevent promoted prostate prostatic pten rasg12v repression senescence sirt1 suppressing tlx transactivation triggered tumour tumourigenesis
Tagcloud (Intersection) ?