ERBIN and ARVCF

Number of citations of the paper that reports this interaction (PubMedID 11821434)
0

Data Source:
HPRD (in vitro, in vivo)

		ERBIN	ARVCF
Description		erbb2 interacting protein	ARVCF delta catenin family member
Image			No pdb structure
GO Annotations	Cellular Component	Basement Membrane Nucleus Cytoplasm Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Nuclear Speck Cell Junction Hemidesmosome Neuromuscular Junction Nuclear Membrane Anchoring Junction Postsynapse Glutamatergic Synapse Postsynaptic Specialization	Nucleus Cytoplasm Plasma Membrane Adherens Junction Anchoring Junction
	Molecular Function	Signaling Receptor Binding ErbB-2 Class Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding	Protein Binding Cadherin Binding
	Biological Process	Protein Targeting Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Gene Expression Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Response To Lipopolysaccharide Intracellular Signal Transduction Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	MRNA Processing Cell Adhesion RNA Splicing Cell-cell Adhesion
Pathways		Signaling by ERBB2 Downregulation of ERBB2 signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs
Diseases			Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Appendicular lean mass ( 33097823) Central corneal thickness ( 29760442 32528159) Lymphocyte count ( 27863252 32888494) Medication use (antihypertensives) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Monocyte count ( 27863252 32888494) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494 22139419) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418 30487518 28739976 28135244 27841878) Systolic blood pressure ( 30578418 30487518 27841878) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) White blood cell count ( 27863252 32888494)
Interacting Genes		66 interacting genes: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 MUSK NOD2 NR2E1 PICK1 PKP4 RAF1 RBX1 RNF7 RPS6KA1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9	6 interacting genes: CDH1 CDH15 CDH2 ERBIN LNX1 TJP1
Entrez ID		55914	421
HPRD ID		06090	03778
Ensembl ID		ENSG00000112851	ENSG00000099889
Uniprot IDs		A0A8V8TML4 A0A8V8TPC7 Q96RT1	C9JJX6 E9PDC3 O00192
PDB IDs		1MFG 1MFL 1N7T 2H3L 2QBW 3CH8 6Q0M 6Q0N 6Q0U 6UBH 7LUL
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane I-SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Heteromeric SMAD Protein Complex Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Basolateral Plasma Membrane Cell Junction Organization Adherens Junction Trophoblast Cell Migration SMAD Protein Complex Regulation Of Signal Transduction Regulation Of System Process Gastrulation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway SMAD Protein Signal Transduction Embryonic Foregut Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anchoring Junction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Cell Junction Assembly Cell Junction Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Protein Kinase Binding Positive Regulation Of RNA Metabolic Process MAPK Cascade Cell-substrate Junction Assembly Response To Growth Factor Metal Ion Transport Transcription Regulator Complex Gastrulation With Mouth Forming Second Cell-substrate Junction Organization Positive Regulation Of Developmental Process Negative Regulation Of Developmental Process Negative Regulation Of Ossification Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Cell Projection Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation	Adherens Junction Organization Cell-cell Junction Assembly Catenin Complex Cell Junction Organization Cell-cell Junction Organization Adherens Junction Cell-cell Adhesion Mediated By Cadherin Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Junction Cell Junction Assembly Cadherin Binding Cell Adhesion Beta-catenin Binding Anchoring Junction Gamma-catenin Binding Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Adhesion Cell Morphogenesis Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Apical Junction Complex Desmosome Postsynapse Basolateral Plasma Membrane Synapse Organization Cortical Actin Cytoskeleton Neuromuscular Junction Apical Part Of Cell Cell Adhesion Molecule Binding Synapse Assembly Positive Regulation Of Synaptic Vesicle Clustering Basal Protein Localization Calcium Ion Binding Epithelial Cell Development Neuroligin Clustering Involved In Postsynaptic Membrane Assembly ErbB-2 Class Receptor Binding Intracellular Protein Localization Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Regulation Of Postsynaptic Density Protein 95 Clustering Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Localization To Plasma Membrane Response To Heparin Cellular Response To Indole-3-methanol Lamellipodium Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Response To Indole-3-methanol Response To Gram-positive Bacterium Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Synaptic Vesicle Clustering Protein Localization To Bicellular Tight Junction
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