ERBIN and KCNA4

Number of citations of the paper that reports this interaction (PubMedID 15123239)
0

Data Source:
BioGRID (unspecified method)

		ERBIN	KCNA4
Description		erbb2 interacting protein	potassium voltage-gated channel subfamily A member 4
Image			No pdb structure
GO Annotations	Cellular Component	Basement Membrane Nucleus Cytoplasm Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Nuclear Speck Cell Junction Hemidesmosome Neuromuscular Junction Nuclear Membrane Anchoring Junction Postsynapse Glutamatergic Synapse Postsynaptic Specialization	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Monoatomic Ion Channel Complex Cell Projection Axon Initial Segment Dendritic Spine
	Molecular Function	Signaling Receptor Binding ErbB-2 Class Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Ion Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
	Biological Process	Protein Targeting Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Gene Expression Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Response To Lipopolysaccharide Intracellular Signal Transduction Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport Regulation Of Presynaptic Membrane Potential
Pathways		Signaling by ERBB2 Downregulation of ERBB2 signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants	Voltage gated Potassium channels
Drugs			Enflurane Promethazine Miconazole Arginineamide Dalfampridine
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Adult body size ( 32376654) Diastolic blood pressure ( 27841878) Luteinizing hormone levels in polycystic ovary syndrome ( 26284813) Menarche (age at onset) ( 27182965) Polycystic ovary syndrome ( 26284813) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878)
Interacting Genes		66 interacting genes: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 MUSK NOD2 NR2E1 PICK1 PKP4 RAF1 RBX1 RNF7 RPS6KA1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9	16 interacting genes: ACTN2 CASK COXFA4L2 DLG1 DLG2 DLG3 DLG4 DLGAP1 ERBIN KCNA2 LNX1 NEU1 PATJ SAT1 SNTA1 SNTG1
Entrez ID		55914	3739
HPRD ID		06090	01444
Ensembl ID		ENSG00000112851	ENSG00000182255
Uniprot IDs		A0A8V8TML4 A0A8V8TPC7 Q96RT1	P22459
PDB IDs		1MFG 1MFL 1N7T 2H3L 2QBW 3CH8 6Q0M 6Q0N 6Q0U 6UBH 7LUL
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane I-SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Heteromeric SMAD Protein Complex Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Basolateral Plasma Membrane Cell Junction Organization Adherens Junction Trophoblast Cell Migration SMAD Protein Complex Regulation Of Signal Transduction Regulation Of System Process Gastrulation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway SMAD Protein Signal Transduction Embryonic Foregut Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anchoring Junction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Cell Junction Assembly Cell Junction Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Protein Kinase Binding Positive Regulation Of RNA Metabolic Process MAPK Cascade Cell-substrate Junction Assembly Response To Growth Factor Metal Ion Transport Transcription Regulator Complex Gastrulation With Mouth Forming Second Cell-substrate Junction Organization Positive Regulation Of Developmental Process Negative Regulation Of Developmental Process Negative Regulation Of Ossification Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Cell Projection Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuromuscular Junction Cell Junction Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Establishment Or Maintenance Of Cell Polarity Ionotropic Glutamate Receptor Binding Postsynaptic Density Membrane GMP Kinase Activity Receptor Localization To Synapse GDP Metabolic Process Receptor Clustering Juxtaparanode Region Of Axon Protein Localization To Synapse Glutamatergic Synapse Protein Localization To Cell Junction Kinase Binding GMP Metabolic Process Basolateral Plasma Membrane Syntrophin Complex Cell Adhesion Protein Localization To Membrane Chemical Synaptic Transmission Neuron Projection Trans-synaptic Signaling Synapse Synaptic Signaling Plasma Membrane Cell Communication Adherens Junction Anchoring Junction Regulation Of Membrane Potential Nucleoside Monophosphate Metabolic Process Postsynaptic Specialization Ribonucleoside Diphosphate Metabolic Process Voltage-gated Potassium Channel Complex PDZ Domain Binding Nucleoside Diphosphate Metabolic Process Cellular Response To Potassium Ion Postsynaptic Density Basement Membrane Dystrophin-associated Glycoprotein Complex Localization Within Membrane Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Nervous System Development Response To Potassium Ion Cell-cell Signaling Bicellular Tight Junction Signaling Transmembrane Transporter Binding
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