ERBIN and MPP2

Number of citations of the paper that reports this interaction (PubMedID 15123239)
0

Data Source:
BioGRID (unspecified method)

		ERBIN	MPP2
Description		erbb2 interacting protein	MAGUK p55 scaffold protein 2
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GO Annotations	Cellular Component	Basement Membrane Nucleus Cytoplasm Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Nuclear Speck Cell Junction Hemidesmosome Neuromuscular Junction Nuclear Membrane Anchoring Junction Postsynapse Glutamatergic Synapse Postsynaptic Specialization	Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Postsynaptic Density Membrane Dendrite Dendrite Membrane Cell Projection Dendritic Spine Dendritic Shaft Organelle Synapse
	Molecular Function	Signaling Receptor Binding ErbB-2 Class Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding	Protein Binding
	Biological Process	Protein Targeting Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Gene Expression Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Response To Lipopolysaccharide Intracellular Signal Transduction Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Protein Homooligomerization Excitatory Postsynaptic Potential Long-term Synaptic Potentiation
Pathways		Signaling by ERBB2 Downregulation of ERBB2 signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Cognitive function ( 24684796)
Interacting Genes		66 interacting genes: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 MUSK NOD2 NR2E1 PICK1 PKP4 RAF1 RBX1 RNF7 RPS6KA1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9	6 interacting genes: CSNK2B DLG1 ERBIN LIN7A LIN7C PLK1
Entrez ID		55914	4355
HPRD ID		06090	02837
Ensembl ID		ENSG00000112851	ENSG00000108852
Uniprot IDs		A0A8V8TML4 A0A8V8TPC7 Q96RT1	A0A0A0MRU0 A0A0C4DH75 B4DRL7 B4DZ84 D3DX48 D3DX49 Q14168
PDB IDs		1MFG 1MFL 1N7T 2H3L 2QBW 3CH8 6Q0M 6Q0N 6Q0U 6UBH 7LUL	2E7K
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane I-SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Heteromeric SMAD Protein Complex Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Basolateral Plasma Membrane Cell Junction Organization Adherens Junction Trophoblast Cell Migration SMAD Protein Complex Regulation Of Signal Transduction Regulation Of System Process Gastrulation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway SMAD Protein Signal Transduction Embryonic Foregut Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anchoring Junction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Cell Junction Assembly Cell Junction Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Protein Kinase Binding Positive Regulation Of RNA Metabolic Process MAPK Cascade Cell-substrate Junction Assembly Response To Growth Factor Metal Ion Transport Transcription Regulator Complex Gastrulation With Mouth Forming Second Cell-substrate Junction Organization Positive Regulation Of Developmental Process Negative Regulation Of Developmental Process Negative Regulation Of Ossification Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Cell Projection Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation	L27 Domain Binding MPP7-DLG1-LIN7 Complex Basolateral Plasma Membrane Establishment Of Organelle Localization Anchoring Junction Postsynaptic Density Membrane Regulation Of Synaptic Assembly At Neuromuscular Junction Bicellular Tight Junction Organelle Localization Cell-cell Junction Protein-macromolecule Adaptor Activity Intracellular Protein Localization Synaptic Vesicle Transport Neurotransmitter Secretion Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Morphogenesis Of An Epithelium Establishment Or Maintenance Of Apical/basal Cell Polarity Tissue Morphogenesis Cytoskeletal Protein Binding Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Establishment Of Protein Localization Basement Membrane Neurotransmitter Transport Establishment Of Vesicle Localization Glutamatergic Synapse Synaptonemal Complex Disassembly Golgi Inheritance Basal Protein Localization Vesicle Localization Establishment Of Localization In Cell Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Structural Constituent Of Postsynaptic Density ErbB-2 Class Receptor Binding Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Mitotic Cell Cycle Phase Transition Lateral Loop Spindle Organization Establishment Or Maintenance Of Cell Polarity Signal Release Regulation Of Synapse Assembly Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Release From Viral Latency Maintenance Of Postsynaptic Density Structure Myelin Sheath Abaxonal Region Homologous Chromosome Segregation Female Meiosis Chromosome Segregation
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