ERBIN and ABR

Number of citations of the paper that reports this interaction (PubMedID 15123239)
0

Data Source:
BioGRID (unspecified method)

		ERBIN	ABR
Description		erbb2 interacting protein	ABR activator of RhoGEF and GTPase
Image			No pdb structure
GO Annotations	Cellular Component	Basement Membrane Nucleus Cytoplasm Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Nuclear Speck Cell Junction Hemidesmosome Neuromuscular Junction Nuclear Membrane Anchoring Junction Postsynapse Glutamatergic Synapse Postsynaptic Specialization	Cytosol Membrane Axon Cell Projection Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding ErbB-2 Class Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Protein Targeting Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Gene Expression Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Response To Lipopolysaccharide Intracellular Signal Transduction Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways		Signaling by ERBB2 Downregulation of ERBB2 signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Appendicular lean mass ( 33097823) Heel bone mineral density ( 28869591 30598549) Height ( 28552196) Total cholesterol levels ( 30498476)
Interacting Genes		66 interacting genes: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 MUSK NOD2 NR2E1 PICK1 PKP4 RAF1 RBX1 RNF7 RPS6KA1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9	7 interacting genes: ADRA1A APP ECT2 ERBIN HRAS LNX1 PJA1
Entrez ID		55914	29
HPRD ID		06090	02649
Ensembl ID		ENSG00000112851	ENSG00000159842
Uniprot IDs		A0A8V8TML4 A0A8V8TPC7 Q96RT1	B7Z2X0 B7Z683 B7Z7Z1 I3L4Y1 Q12979 Q6ZT60
PDB IDs		1MFG 1MFL 1N7T 2H3L 2QBW 3CH8 6Q0M 6Q0N 6Q0U 6UBH 7LUL
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane I-SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Heteromeric SMAD Protein Complex Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Basolateral Plasma Membrane Cell Junction Organization Adherens Junction Trophoblast Cell Migration SMAD Protein Complex Regulation Of Signal Transduction Regulation Of System Process Gastrulation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway SMAD Protein Signal Transduction Embryonic Foregut Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anchoring Junction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Cell Junction Assembly Cell Junction Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Protein Kinase Binding Positive Regulation Of RNA Metabolic Process MAPK Cascade Cell-substrate Junction Assembly Response To Growth Factor Metal Ion Transport Transcription Regulator Complex Gastrulation With Mouth Forming Second Cell-substrate Junction Organization Positive Regulation Of Developmental Process Negative Regulation Of Developmental Process Negative Regulation Of Ossification Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Cell Projection Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation	Negative Regulation Of Blood Circulation Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Type II Interferon Production Postsynapse Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Cell Death Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of ERK1 And ERK2 Cascade Intracellular Signaling Cassette Positive Regulation Of Signaling Programmed Cell Death Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Positive Regulation Of Establishment Of Protein Localization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Type II Interferon Production Regulation Of Cytokine Production Glial Cell Development Adrenergic Receptor Binding Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Cellular Response To Ionizing Radiation Regulation Of Immune Response Regulation Of Cell Communication Cytoplasm Regulation Of Signal Transduction Developmental Cell Growth Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Pilomotor Reflex Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of MAPK Cascade Alpha1-adrenergic Receptor Activity Phospholipase C-activating Adrenergic Receptor Signaling Pathway Regulation Of Signaling Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Multicellular Organismal Process Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Modulation Of Chemical Synaptic Transmission Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury
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