MAPK8IP2 and CTNNBL1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		MAPK8IP2	CTNNBL1
Description		mitogen-activated protein kinase 8 interacting protein 2	catenin beta like 1
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GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Protein-containing Complex Neuronal Cell Body	Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Centrosome Cytosol Membrane
	Molecular Function	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding JUN Kinase Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein-containing Complex Binding	Protein Binding Enzyme Binding
	Biological Process	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Apoptotic Signaling Pathway	MRNA Splicing, Via Spliceosome Adaptive Immune Response Immune System Process MRNA Processing RNA Splicing Gene Expression Somatic Diversification Of Immunoglobulins Positive Regulation Of Apoptotic Process
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Cutaneous leishmaniasis ( 32830257) Gut microbiota relative abundance (Prevotella) ( 33208821) Hip circumference ( 28552196)	Body size at age 10 ( 32376654) Bone mineral density ( 17903296) California verbal learning test score ( 31596458) Falling risk ( 32999390) Fasting glucose ( 34074324)
Interacting Genes		86 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C HOXC8 IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 POLR1H PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RSPH1 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784	26 interacting genes: BEX3 BUD31 CALCOCO1 CATIP CDCA7L CREBZF ERP29 HMGB1 HNRNPK IK LDOC1 LUC7L MAPK8IP2 MED4 MEOX2 NSRP1 PPP1R8 PRDM4 PRPF3 SPP1 SRPK2 STAMBP SUMO2 U2SURP WBP11 ZCCHC10
Entrez ID		23542	56259
HPRD ID		09674	10850
Ensembl ID		ENSG00000008735	ENSG00000132792
Uniprot IDs		Q13387	Q8WYA6
PDB IDs		8RPP	4CB8 4CB9 4CBA 4HM9 4HNM 4MFU 4MFV 7ABI
Enriched GO Terms of Interacting Partners?		MAPK Cascade JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process JUN Kinase Activity Regulation Of Apoptotic Process Growth Cone Regulation Of Programmed Cell Death Cellular Senescence MAP Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Response To Light Stimulus MAP Kinase Kinase Kinase Activity Fc-epsilon Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Protein Serine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity JUN Kinase Binding Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphate Metabolic Process Clathrin-coated Pit Hippocampus Development Positive Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Low-density Lipoprotein Particle Receptor Activity MAP Kinase Kinase Activity Receptor Complex Kinase Activity Kinesin Binding Regulation Of Signaling Response To Radiation Positive Regulation Of Kinase Activity Regulation Of Voltage-gated Sodium Channel Activity Positive Regulation Of Apoptotic Process Apolipoprotein Binding Regulation Of Protein Modification Process Regulation Of JNK Cascade	RNA Splicing MRNA Processing RNA Metabolic Process RNA Processing MRNA Metabolic Process Spliceosomal Complex Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Speck Nucleoplasm Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Positive Regulation Of Macromolecule Metabolic Process Macrophage Activation Involved In Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Transcription Coactivator Activity Regulation Of Toll-like Receptor 4 Signaling Pathway Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Lipopolysaccharide Binding Protein Binding Positive Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Cellular Response To Stress Regulation Of MRNA Processing Ribonuclease E Activity Molecular Function Inhibitor Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Gene Expression
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