MAPK8IP2 and SCLT1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		MAPK8IP2	SCLT1
Description		mitogen-activated protein kinase 8 interacting protein 2	sodium channel and clathrin linker 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Protein-containing Complex Neuronal Cell Body	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Microtubule Cytoskeleton Ciliary Basal Body Clathrin Complex Ciliary Transition Fiber
	Molecular Function	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding JUN Kinase Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein-containing Complex Binding	Protein Binding Sodium Channel Regulator Activity Clathrin Binding
	Biological Process	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Apoptotic Signaling Pathway	Clustering Of Voltage-gated Sodium Channels Cilium Assembly
Pathways			Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		Cutaneous leishmaniasis ( 32830257) Gut microbiota relative abundance (Prevotella) ( 33208821) Hip circumference ( 28552196)	Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Metabolite levels ( 23823483) Problematic alcohol use in trauma-exposed individuals ( 29082582) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		86 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C HOXC8 IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 POLR1H PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RSPH1 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784	5 interacting genes: CALM1 IKBKG LNX1 MAPK8IP2 SCN10A
Entrez ID		23542	132320
HPRD ID		09674	08700
Ensembl ID		ENSG00000008735	ENSG00000151466
Uniprot IDs		Q13387	A0A494C0G8 D6RBA6 Q96NL6
PDB IDs		8RPP
Enriched GO Terms of Interacting Partners?		MAPK Cascade JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process JUN Kinase Activity Regulation Of Apoptotic Process Growth Cone Regulation Of Programmed Cell Death Cellular Senescence MAP Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Response To Light Stimulus MAP Kinase Kinase Kinase Activity Fc-epsilon Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Protein Serine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity JUN Kinase Binding Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphate Metabolic Process Clathrin-coated Pit Hippocampus Development Positive Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Low-density Lipoprotein Particle Receptor Activity MAP Kinase Kinase Activity Receptor Complex Kinase Activity Kinesin Binding Regulation Of Signaling Response To Radiation Positive Regulation Of Kinase Activity Regulation Of Voltage-gated Sodium Channel Activity Positive Regulation Of Apoptotic Process Apolipoprotein Binding Regulation Of Protein Modification Process Regulation Of JNK Cascade	Regulation Of Heart Contraction Transmembrane Transporter Binding Regulation Of Muscle Contraction Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Intracellular Signaling Cassette Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Membrane Potential Autophagosome Membrane Docking Protein-containing Complex Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Muscle System Process Regulation Of Cardiac Muscle Contraction Regulation Of System Process Spindle Pole Regulation Of Heart Rate Regulation Of Striated Muscle Contraction AV Node Cell Action Potential Bundle Of His Cell Action Potential Negative Regulation Of Apoptotic Signaling Pathway Linear Polyubiquitin Binding IkappaB Kinase Complex Nonassociative Learning Regulation Of Blood Circulation Negative Regulation Of Voltage-gated Calcium Channel Activity Clathrin Complex Signal Complex Assembly Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Transferrin Receptor Binding JUN Kinase Binding Voltage-gated Sodium Channel Complex Anoikis MAP-kinase Scaffold Activity Titin Binding Calcium Channel Inhibitor Activity Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Protein Phosphatase Activator Activity Regulation Of Cell Communication By Electrical Coupling Calyx Of Held Regulation Of Monoatomic Ion Transport
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