MAPK8IP2 and MNDA

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		MAPK8IP2	MNDA
Description		mitogen-activated protein kinase 8 interacting protein 2	myeloid cell nuclear differentiation antigen
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GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Protein-containing Complex Neuronal Cell Body	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Azurophil Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding JUN Kinase Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein-containing Complex Binding	DNA Binding Double-stranded DNA Binding Protein Binding
	Biological Process	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Apoptotic Signaling Pathway	Activation Of Innate Immune Response Cellular Defense Response DNA Damage Response Negative Regulation Of B Cell Proliferation Cellular Response To Interferon-beta Positive Regulation Of Apoptotic Process B Cell Receptor Signaling Pathway
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Cutaneous leishmaniasis ( 32830257) Gut microbiota relative abundance (Prevotella) ( 33208821) Hip circumference ( 28552196)	Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Perceived intensity of aspartame ( 31005972)
Interacting Genes		86 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C HOXC8 IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 POLR1H PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RSPH1 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784	14 interacting genes: CDK1 CDK2 CEBPA CRK FBXO7 HOXB2 MAPK8IP2 NSD3 PRMT6 PRMT7 RB1 RBL2 STAT3 TP53
Entrez ID		23542	4332
HPRD ID		09674	15932
Ensembl ID		ENSG00000008735	ENSG00000163563
Uniprot IDs		Q13387	P41218 Q5VUU6
PDB IDs		8RPP	2DBG 5H7Q 5WPZ 8I6K
Enriched GO Terms of Interacting Partners?		MAPK Cascade JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process JUN Kinase Activity Regulation Of Apoptotic Process Growth Cone Regulation Of Programmed Cell Death Cellular Senescence MAP Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Response To Light Stimulus MAP Kinase Kinase Kinase Activity Fc-epsilon Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Protein Serine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity JUN Kinase Binding Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphate Metabolic Process Clathrin-coated Pit Hippocampus Development Positive Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Low-density Lipoprotein Particle Receptor Activity MAP Kinase Kinase Activity Receptor Complex Kinase Activity Kinesin Binding Regulation Of Signaling Response To Radiation Positive Regulation Of Kinase Activity Regulation Of Voltage-gated Sodium Channel Activity Positive Regulation Of Apoptotic Process Apolipoprotein Binding Regulation Of Protein Modification Process Regulation Of JNK Cascade	Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Transcription Regulator Complex Negative Regulation Of Cell Cycle Process Chromatin Organization Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle G1/S Phase Transition Chromatin Remodeling Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Intracellular Signaling Cassette Histone Methyltransferase Activity Regulation Of Lipid Kinase Activity Nucleoplasm Regulation Of Transcription By RNA Polymerase II Rb-E2F Complex Glial Cell Apoptotic Process Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Nucleus Histone Kinase Activity Chromatin Cell Population Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of MiRNA Processing Regulation Of Cell Cycle Process Cellular Senescence DNA-templated Transcription Cellular Response To Xenobiotic Stimulus Regulation Of Hemopoiesis Protein-arginine N-methyltransferase Activity Mitotic DNA Damage Checkpoint Signaling Protein-containing Complex Mitotic DNA Integrity Checkpoint Signaling Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Ras Protein Signal Transduction Regulation Of Cell Development G1/S Transition Of Mitotic Cell Cycle
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