MAPK8IP2 and BBS10

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAPK8IP2	BBS10
Description		mitogen-activated protein kinase 8 interacting protein 2	Bardet-Biedl syndrome 10
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Protein-containing Complex Neuronal Cell Body	Cilium Cell Projection
	Molecular Function	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding JUN Kinase Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein-containing Complex Binding	Nucleotide Binding Protein Binding ATP Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Apoptotic Signaling Pathway	Visual Perception Intracellular Protein Localization Response To Light Stimulus Neuronal Action Potential Response To Endoplasmic Reticulum Stress Retinal Cone Cell Differentiation Regulation Of Protein-containing Complex Assembly Negative Regulation Of Neuron Apoptotic Process Photoreceptor Cell Maintenance Photoreceptor Cell Differentiation Chaperone-mediated Protein Complex Assembly Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Cone Retinal Bipolar Cell Differentiation Non-motile Cilium Assembly
Pathways			BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Cutaneous leishmaniasis ( 32830257) Gut microbiota relative abundance (Prevotella) ( 33208821) Hip circumference ( 28552196)
Interacting Genes		86 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C HOXC8 IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 POLR1H PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RSPH1 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784	12 interacting genes: CSNK1E FRZB HDAC6 MAP3K7 MAPK6 MAPK8IP2 NR4A1 PTK2 RASA1 RGS2 TNFSF11 YAE1
Entrez ID		23542	79738
HPRD ID		09674	08036
Ensembl ID		ENSG00000008735	ENSG00000179941
Uniprot IDs		Q13387	Q8TAM1
PDB IDs		8RPP
Enriched GO Terms of Interacting Partners?		MAPK Cascade JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process JUN Kinase Activity Regulation Of Apoptotic Process Growth Cone Regulation Of Programmed Cell Death Cellular Senescence MAP Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Response To Light Stimulus MAP Kinase Kinase Kinase Activity Fc-epsilon Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Protein Serine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity JUN Kinase Binding Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphate Metabolic Process Clathrin-coated Pit Hippocampus Development Positive Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Low-density Lipoprotein Particle Receptor Activity MAP Kinase Kinase Activity Receptor Complex Kinase Activity Kinesin Binding Regulation Of Signaling Response To Radiation Positive Regulation Of Kinase Activity Regulation Of Voltage-gated Sodium Channel Activity Positive Regulation Of Apoptotic Process Apolipoprotein Binding Regulation Of Protein Modification Process Regulation Of JNK Cascade	Signal Complex Assembly JNK Cascade MAPK Cascade JUN Kinase Binding Signal Transduction Regulation Of Intracellular Signal Transduction MAP Kinase Activity Positive Regulation Of Signal Transduction Protein Phosphorylation Phosphorylation Positive Regulation Of Cell Communication Cytoplasm Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Cell Growth Response To Amphetamine Regulation Of JNK Cascade Regulation Of Cell Communication Protein Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Signaling Non-canonical Wnt Signaling Pathway Negative Regulation Of Hepatocyte Differentiation Regulation Of Apoptotic Process Negative Regulation Of Growth Protein Kinase Binding Positive Regulation Of Epithelial Cell Migration Ephrin Receptor Signaling Pathway Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Beta-tubulin Binding Response To Amine Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Fc Receptor Signaling Pathway Positive Regulation Of Catabolic Process Regulation Of Cell Morphogenesis Cellular Response To Growth Factor Stimulus Kinase Activity Septin Cytoskeleton Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Glycine Import Across Plasma Membrane Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation
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