MAPK8IP2 and C1QTNF3

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		MAPK8IP2	C1QTNF3
Description		mitogen-activated protein kinase 8 interacting protein 2	C1q and TNF related 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Protein-containing Complex Neuronal Cell Body	Extracellular Region Collagen Trimer Membrane Extracellular Exosome
	Molecular Function	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding JUN Kinase Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein-containing Complex Binding	Protein Binding Identical Protein Binding
	Biological Process	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of Cytokine Production Negative Regulation Of Gene Expression Negative Regulation Of Interleukin-6 Production Intracellular Triglyceride Homeostasis Fat Cell Differentiation Negative Regulation Of Gluconeogenesis Chemical Homeostasis Negative Regulation Of Inflammatory Response Positive Regulation Of Adiponectin Secretion Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS		Cutaneous leishmaniasis ( 32830257) Gut microbiota relative abundance (Prevotella) ( 33208821) Hip circumference ( 28552196)	Blood protein levels ( 30072576) Estimated glomerular filtration rate ( 30604766) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		86 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C HOXC8 IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 POLR1H PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RSPH1 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784	1 interacting genes: MAPK8IP2
Entrez ID		23542	114899
HPRD ID		09674	12716
Ensembl ID		ENSG00000008735	ENSG00000082196
Uniprot IDs		Q13387	Q9BXJ4
PDB IDs		8RPP
Enriched GO Terms of Interacting Partners?		MAPK Cascade JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process JUN Kinase Activity Regulation Of Apoptotic Process Growth Cone Regulation Of Programmed Cell Death Cellular Senescence MAP Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Response To Light Stimulus MAP Kinase Kinase Kinase Activity Fc-epsilon Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Protein Serine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity JUN Kinase Binding Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphate Metabolic Process Clathrin-coated Pit Hippocampus Development Positive Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Low-density Lipoprotein Particle Receptor Activity MAP Kinase Kinase Activity Receptor Complex Kinase Activity Kinesin Binding Regulation Of Signaling Response To Radiation Positive Regulation Of Kinase Activity Regulation Of Voltage-gated Sodium Channel Activity Positive Regulation Of Apoptotic Process Apolipoprotein Binding Regulation Of Protein Modification Process Regulation Of JNK Cascade	MAP-kinase Scaffold Activity Signal Complex Assembly Kinesin Binding Fear Response Positive Regulation Of Stress-activated MAPK Cascade Mating Behavior JUN Kinase Binding Behavioral Fear Response Behavioral Defense Response Regulation Of Stress-activated Protein Kinase Signaling Cascade Reproductive Behavior Protein Kinase Activator Activity Nonassociative Learning Regulation Of Stress-activated MAPK Cascade Dendrite Morphogenesis Modulation Of Excitatory Postsynaptic Potential Social Behavior JNK Cascade Multicellular Organismal Response To Stress Regulation Of Synaptic Transmission, Glutamatergic Amyloid-beta Binding Regulation Of Nervous System Process Regulation Of JNK Cascade Learning Structural Molecule Activity Negative Regulation Of Apoptotic Signaling Pathway MAPK Cascade Learning Or Memory Cell Projection Morphogenesis Postsynaptic Density Neuron Projection Morphogenesis
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