MAPK8IP2 and SMS

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAPK8IP2	SMS
Description		mitogen-activated protein kinase 8 interacting protein 2	spermine synthase
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GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Protein-containing Complex Neuronal Cell Body	Cytosol Extracellular Exosome
	Molecular Function	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding JUN Kinase Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein-containing Complex Binding	Transferase Activity Spermine Synthase Activity
	Biological Process	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Apoptotic Signaling Pathway	Methionine Metabolic Process Polyamine Metabolic Process Polyamine Biosynthetic Process Spermine Biosynthetic Process Spermine Metabolic Process
Pathways			Metabolism of polyamines
Drugs			Spermine
Diseases			Snyder-Robinson syndrome
GWAS		Cutaneous leishmaniasis ( 32830257) Gut microbiota relative abundance (Prevotella) ( 33208821) Hip circumference ( 28552196)
Interacting Genes		86 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C HOXC8 IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 POLR1H PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RSPH1 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784	6 interacting genes: CEBPA EZH2 MAPK6 MAPK8IP2 MAPKAPK3 RPS6KA3
Entrez ID		23542	6611
HPRD ID		09674	02115
Ensembl ID		ENSG00000008735	ENSG00000102172
Uniprot IDs		Q13387	P52788
PDB IDs		8RPP	3C6K 3C6M
Enriched GO Terms of Interacting Partners?		MAPK Cascade JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process JUN Kinase Activity Regulation Of Apoptotic Process Growth Cone Regulation Of Programmed Cell Death Cellular Senescence MAP Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Response To Light Stimulus MAP Kinase Kinase Kinase Activity Fc-epsilon Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Protein Serine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity JUN Kinase Binding Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphate Metabolic Process Clathrin-coated Pit Hippocampus Development Positive Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Low-density Lipoprotein Particle Receptor Activity MAP Kinase Kinase Activity Receptor Complex Kinase Activity Kinesin Binding Regulation Of Signaling Response To Radiation Positive Regulation Of Kinase Activity Regulation Of Voltage-gated Sodium Channel Activity Positive Regulation Of Apoptotic Process Apolipoprotein Binding Regulation Of Protein Modification Process Regulation Of JNK Cascade	Negative Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Transcription Elongation By RNA Polymerase II Intracellular Signaling Cassette Response To Lipid Intracellular Signal Transduction Animal Organ Regeneration MAPK Cascade Toll-like Receptor Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Hepatocyte Homeostasis Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity U6 2'-O-snRNA Methylation Nucleoplasm Chromatin DNA Binding Response To Vitamin B2 Positive Regulation Of Defense Response Liver Development C/EBP Complex Cellular Response To Trichostatin A Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Septin Cytoskeleton Protein Kinase Binding Protein Kinase Activity CHOP-C/EBP Complex Positive Regulation Of Developmental Process Regeneration Histone H3K27 Trimethyltransferase Activity Response To Tetrachloromethane Box C/D Sno(s)RNA 3'-end Processing Kinase Activity White Fat Cell Proliferation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Histone H3K27 Methyltransferase Activity Innate Immune Response-activating Signaling Pathway Ribosomal Protein S6 Kinase Activity Calcium-dependent Protein Serine/threonine Kinase Activity SnRNA Modification Response To Phenylpropanoid Protein-containing Complex Pronucleus Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Transferase Activity Methylation
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