MAPK8IP2 and NDUFS6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAPK8IP2	NDUFS6
Description		mitogen-activated protein kinase 8 interacting protein 2	NADH:ubiquinone oxidoreductase subunit S6
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GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Protein-containing Complex Neuronal Cell Body	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I
	Molecular Function	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding JUN Kinase Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein-containing Complex Binding	NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity
	Biological Process	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Apoptotic Signaling Pathway	Kidney Development Mitochondrial Electron Transport, NADH To Ubiquinone Fatty Acid Metabolic Process Muscle Contraction Mitochondrion Organization Aerobic Respiration Gene Expression Stem Cell Division Respiratory Electron Transport Chain DNA Damage Response, Signal Transduction By P53 Class Mediator Mitochondrial Respiratory Chain Complex I Assembly Multicellular Organism Growth Proton Motive Force-driven Mitochondrial ATP Synthesis Regulation Of Mitochondrial Membrane Potential Reproductive System Development Circulatory System Development Mesenchymal Stem Cell Differentiation Reactive Oxygen Species Metabolic Process Cellular Senescence Mesenchymal Stem Cell Proliferation Proton Transmembrane Transport
Pathways			Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Cutaneous leishmaniasis ( 32830257) Gut microbiota relative abundance (Prevotella) ( 33208821) Hip circumference ( 28552196)	Lack of perseverance ( 30718321) Metabolite levels ( 23823483)
Interacting Genes		86 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C HOXC8 IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 POLR1H PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RSPH1 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784	5 interacting genes: FGFR3 KCNH2 MAP3K7 MAPK6 MAPK8IP2
Entrez ID		23542	4726
HPRD ID		09674	10356
Ensembl ID		ENSG00000008735	ENSG00000145494
Uniprot IDs		Q13387	O75380 Q6IBC4
PDB IDs		8RPP	5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		MAPK Cascade JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process JUN Kinase Activity Regulation Of Apoptotic Process Growth Cone Regulation Of Programmed Cell Death Cellular Senescence MAP Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Response To Light Stimulus MAP Kinase Kinase Kinase Activity Fc-epsilon Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Protein Serine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity JUN Kinase Binding Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphate Metabolic Process Clathrin-coated Pit Hippocampus Development Positive Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Low-density Lipoprotein Particle Receptor Activity MAP Kinase Kinase Activity Receptor Complex Kinase Activity Kinesin Binding Regulation Of Signaling Response To Radiation Positive Regulation Of Kinase Activity Regulation Of Voltage-gated Sodium Channel Activity Positive Regulation Of Apoptotic Process Apolipoprotein Binding Regulation Of Protein Modification Process Regulation Of JNK Cascade	MAPK Cascade Protein Kinase Activity MAP Kinase Activity Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Intracellular Signaling Cassette Transferase Activity Positive Regulation Of Signaling Scaffold Protein Binding Protein Serine/threonine Kinase Activity Phosphorylation Protein Phosphorylation Protein Serine Kinase Activity Positive Regulation Of Androgen Receptor Signaling Pathway JNK Cascade Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Smooth Muscle Cell Migration Transcription Coactivator Binding Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Protein Kinase Binding Positive Regulation Of Smooth Muscle Cell Proliferation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Heart Rate By Hormone Septin Cytoskeleton Negative Regulation Of Protein Autoubiquitination Positive Regulation Of Hair Cycle Telomerase Catalytic Core Complex ATP Binding Bone Maturation Regulation Of Biological Quality Negative Regulation Of Signal Transduction Cellular Response To Hypoxia I-kappaB Phosphorylation Linear Polyubiquitin Binding RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA-directed DNA Polymerase Activity Cellular Response To Decreased Oxygen Levels Positive Regulation Of Phospholipase Activity Regulation Of Protein Modification Process
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