SNX3 and STX11

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SNX3	STX11
Gene Name		sorting nexin 3	syntaxin 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Endosome Membrane Extrinsic Component Of Membrane Clathrin-coated Vesicle Retromer Complex Early Endosome Membrane Early Phagosome Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Golgi Apparatus Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane SNARE Complex
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Response To Bacterium Membrane Invagination Positive Regulation Of Neuron Projection Development Vesicle Organization Protein To Membrane Docking Regulation Of Wnt Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Protein Transport Transferrin Transport Negative Regulation Of Protein Catabolic Process Hemoglobin Biosynthetic Process Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Phagocytosis Negative Regulation Of Protein Transport Intralumenal Vesicle Formation Negative Regulation Of Early Endosome To Late Endosome Transport	Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Membrane Neutrophil Degranulation Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Vesicle Docking Membrane Fusion
Pathways		WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ARL6IP1 BARD1 BRCA1 LIG4 PAXIP1 SCNN1A STX11 USP10 VPS35	62 interactors: AES APP BLOC1S6 BYSL C1orf109 CARD9 CCBE1 CCDC184 CCDC33 CCNK CDCA7L CTBP2 CWF19L2 EIF1AD FAM110A FAM161A FAM74A4 FAM90A1 FARS2 FHL5 GOLGA8EP GOLGA8F HAUS1 IKBKG IKZF3 KAT5 KCTD9 KDM1A KLC3 KXD1 LENG1 LONRF1 MBIP MEOX2 MFAP1 MID2 NDC80 PPP1R18 PRKAB2 PRPF31 PSMA3 PSMC3 RUNX1T1 SH2D4A SLC38A2 SMARCE1 SNAP23 SNAP25 SNX3 STXBP1 SUV39H1 TAF6L TBK1 TCF4 TNFRSF21 USHBP1 VAMP2 VPS52 WDYHV1 ZCCHC10 ZNF417 ZNF587
Entrez ID		8724	8676
HPRD ID		09333	09231
Ensembl ID		ENSG00000112335
Uniprot IDs		O60493	O75558
PDB IDs		2YPS
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Protein K6-linked Ubiquitination Signal Transduction In Response To DNA Damage Cellular Response To DNA Damage Stimulus Signal Transduction By P53 Class Mediator Positive Regulation Of Histone H3-K4 Methylation DNA Metabolic Process Response To Ionizing Radiation Positive Regulation Of Histone Acetylation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Positive Regulation Of Histone Methylation DNA Recombination Cellular Response To Stress Regulation Of Histone Acetylation Regulation Of Histone Methylation Positive Regulation Of Histone Modification Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation DNA Ligation Involved In DNA Recombination Positive Regulation Of Histone H4-K16 Acetylation Response To Stress Response To Radiation Negative Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone H3-K9 Acetylation Negative Regulation Of Late Endosome To Lysosome Transport Negative Regulation Of Intracellular Transport Regulation Of Histone Modification Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Leukocyte Activation Involved In Immune Response Protein Polyubiquitination Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Lagging Strand Elongation Pro-B Cell Differentiation Negative Regulation Of Protein Export From Nucleus Dosage Compensation By Inactivation Of X Chromosome Neutrophil Degranulation Cytotoxic T Cell Degranulation Regulation Of Chromosome Organization Regulation Of Protein Ubiquitination Establishment Of Integrated Proviral Latency Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation	Neurotransmitter Secretion Glutamate Secretion Vesicle Localization Regulation Of Neurotransmitter Levels Neurotransmitter Transport Gene Expression Organelle Localization Synaptic Vesicle Transport Establishment Of Vesicle Localization Establishment Of Organelle Localization Vesicle Organization Synaptic Vesicle Exocytosis Acid Secretion Energy Reserve Metabolic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Binding Dicarboxylic Acid Transport Organelle Organization Membrane Docking Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Exocytosis RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Secretion By Cell Regulation Of RNA Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of RNA Metabolic Process Viral Process Synaptic Vesicle Docking Membrane Fusion Axon Cargo Transport Synaptic Vesicle Priming Regulation Of Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Vesicle Fusion Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Generation Of Precursor Metabolites And Energy Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Protein Binding Negative Regulation Of Canonical Wnt Signaling Pathway Macromolecule Biosynthetic Process Cellular Localization
Tagcloud ?		altogether biogenesis degradative depends detachment endocytic endocytosis endosomal endosomes find homology intralumenal knockdown lysosomes maturation multivesicular nexin phosphoinositides prevents px recycling redundant restores retrograde shares snx12 sorting turn vesicles	autosomal characterised defect done dysregulation familial families fhl haemophagocytic harbour harbouring killer leukaemia lymphohistiocytosis milder mutational myelogenous nonsense perforin periods prf1 psychomotor recessive retardation segregation syntaxin uncommon undertaken unrelated
Tagcloud (Difference) ?		altogether biogenesis degradative depends detachment endocytic endocytosis endosomal endosomes find homology intralumenal knockdown lysosomes maturation multivesicular nexin phosphoinositides prevents px recycling redundant restores retrograde shares snx12 sorting turn vesicles	autosomal characterised defect done dysregulation familial families fhl haemophagocytic harbour harbouring killer leukaemia lymphohistiocytosis milder mutational myelogenous nonsense perforin periods prf1 psychomotor recessive retardation segregation syntaxin uncommon undertaken unrelated
Tagcloud (Intersection) ?