SNX3

Description		sorting nexin 3
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Clathrin-coated Vesicle Retromer Complex Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-5-phosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol Phosphate Binding Retromer Complex Binding
	Biological Process	Response To Bacterium Membrane Invagination Positive Regulation Of Neuron Projection Development Protein Transport Protein To Membrane Docking Regulation Of Wnt Signaling Pathway Endocytic Recycling Late Endosome To Golgi Transport Negative Regulation Of Protein Catabolic Process Host-mediated Suppression Of Symbiont Invasion Negative Regulation Of Phagocytosis Negative Regulation Of Protein Transport Intralumenal Vesicle Formation Negative Regulation Of Early Endosome To Late Endosome Transport
Pathways		WNT ligand biogenesis and trafficking Ub-specific processing proteases
Drugs		S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
GWAS
Interacting Genes		10 interacting genes: ARL6IP1 BARD1 BRCA1 LIG4 PAXIP1 RPRM SCNN1A STX11 TSC22D2 USP10
Entrez ID		8724
HPRD ID		09333
Ensembl ID		ENSG00000112335
Uniprot IDs		O60493
PDB IDs		2MXC 2YPS 5F0J 5F0L 5F0M 5F0P 7BLO
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Response To Ionizing Radiation BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex DNA Repair BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Cellular Response To Ionizing Radiation DNA Recombination DNA Strand Resection Involved In Replication Fork Processing DNA Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition DNA Damage Response Regulation Of DNA Damage Checkpoint Response To Radiation Signal Transduction In Response To DNA Damage Protein K6-linked Ubiquitination Cellular Response To Radiation Regulation Of Cell Cycle Condensed Chromosome Postreplication Repair Homologous Recombination DNA Damage Response, Signal Transduction By P53 Class Mediator Chromatin Remodeling Mitotic G2/M Transition Checkpoint Negative Regulation Of MRNA 3'-end Processing Establishment Of Integrated Proviral Latency Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle P53 Binding Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Chromatin Organization Negative Regulation Of Apoptotic Process Cellular Response To Stress Establishment Of Viral Latency Negative Regulation Of Stress Granule Assembly DNA Biosynthetic Process Negative Regulation Of Programmed Cell Death Signal Transduction By P53 Class Mediator Ubiquitin Ligase Complex Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Ligase (ATP) Activity DNA Ligase IV Complex DNA Ligase Activity Chorion Development Pro-B Cell Differentiation
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