SNX3 and SCNN1A

Number of citations of the paper that reports this interaction (PubMedID 18632802)
0

Data Source:
HPRD (in vivo)

		SNX3	SCNN1A
Description		sorting nexin 3	sodium channel epithelial 1 subunit alpha
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Clathrin-coated Vesicle Retromer Complex Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Phagocytic Vesicle Extracellular Exosome	Acrosomal Vesicle Cytoplasm Cytosol Plasma Membrane Cilium External Side Of Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Motile Cilium Sodium Channel Complex Cell Projection Ciliary Membrane Extracellular Exosome Sperm Principal Piece
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-5-phosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol Phosphate Binding Retromer Complex Binding	Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process	Response To Bacterium Membrane Invagination Positive Regulation Of Neuron Projection Development Protein Transport Protein To Membrane Docking Regulation Of Wnt Signaling Pathway Endocytic Recycling Late Endosome To Golgi Transport Negative Regulation Of Protein Catabolic Process Host-mediated Suppression Of Symbiont Invasion Negative Regulation Of Phagocytosis Negative Regulation Of Protein Transport Intralumenal Vesicle Formation Negative Regulation Of Early Endosome To Late Endosome Transport	Monoatomic Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of Blood Pressure Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Sensory Perception Of Sour Taste Sodium Ion Homeostasis Cellular Response To Acidic PH Sodium Ion Import Across Plasma Membrane Cellular Response To Aldosterone Cellular Response To Vasopressin
Pathways		WNT ligand biogenesis and trafficking Ub-specific processing proteases	Stimuli-sensing channels Sensory perception of salty taste
Drugs		S,S-(2-Hydroxyethyl)Thiocysteine	Triamterene Amiloride
Diseases			Bronchiectasis with or without elevated sweat chloride Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS			Adverse response to drug ( 30420678) Alopecia areata ( 25608926) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity (early onset extreme) ( 23563609) Primary biliary cirrhosis ( 22961000) Spleen volume ( 34128465)
Interacting Genes		10 interacting genes: ARL6IP1 BARD1 BRCA1 LIG4 PAXIP1 RPRM SCNN1A STX11 TSC22D2 USP10	17 interacting genes: COMMD10 CSNK2A1 EPN1 HECW1 ITCH NEDD4 NEDD4L SCNN1B SCNN1G SERP1 SNX3 STX1A TSG101 UBE2I USP10 WWP1 WWP2
Entrez ID		8724	6337
HPRD ID		09333	02575
Ensembl ID		ENSG00000112335	ENSG00000111319
Uniprot IDs		O60493	P37088
PDB IDs		2MXC 2YPS 5F0J 5F0L 5F0M 5F0P 7BLO	2M3O 6BQN 6WTH
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Response To Ionizing Radiation BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex DNA Repair BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Cellular Response To Ionizing Radiation DNA Recombination DNA Strand Resection Involved In Replication Fork Processing DNA Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition DNA Damage Response Regulation Of DNA Damage Checkpoint Response To Radiation Signal Transduction In Response To DNA Damage Protein K6-linked Ubiquitination Cellular Response To Radiation Regulation Of Cell Cycle Condensed Chromosome Postreplication Repair Homologous Recombination DNA Damage Response, Signal Transduction By P53 Class Mediator Chromatin Remodeling Mitotic G2/M Transition Checkpoint Negative Regulation Of MRNA 3'-end Processing Establishment Of Integrated Proviral Latency Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle P53 Binding Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Chromatin Organization Negative Regulation Of Apoptotic Process Cellular Response To Stress Establishment Of Viral Latency Negative Regulation Of Stress Granule Assembly DNA Biosynthetic Process Negative Regulation Of Programmed Cell Death Signal Transduction By P53 Class Mediator Ubiquitin Ligase Complex Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Ligase (ATP) Activity DNA Ligase IV Complex DNA Ligase Activity Chorion Development Pro-B Cell Differentiation	Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Macromolecule Catabolic Process Negative Regulation Of Potassium Ion Export Across Plasma Membrane Post-translational Protein Modification Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Regulation Of Potassium Ion Export Across Plasma Membrane Transmembrane Transporter Binding Protein Monoubiquitination Proteolysis Ubiquitin Protein Ligase Activity Protein Modification Process Negative Regulation Of Potassium Ion Transmembrane Transport Protein Ubiquitination Import Into Cell Sodium Ion Import Across Plasma Membrane Protein Metabolic Process Negative Regulation Of Potassium Ion Transport Catabolic Process Sensory Perception Of Salty Taste Extracellular Exosome Macromolecule Metabolic Process Biological Process Involved In Interaction With Host Cellular Response To Aldosterone Sodium Channel Complex Protein Catabolic Process Sodium Channel Inhibitor Activity Sensory Perception Of Sour Taste Cellular Response To Vasopressin Regulation Of Protein Catabolic Process Sodium Ion Transport Establishment Of Protein Localization To Vacuole Regulation Of Dendrite Morphogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Receptor Internalization Positive Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Negative Regulation Of Monoatomic Ion Transmembrane Transport Cytosol Cellular Response To Mineralocorticoid Stimulus Ligand-gated Sodium Channel Activity Regulation Of Protein Transport Endocytosis Endosome Negative Regulation Of Sodium Ion Transport
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