SNX3 and RPRM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SNX3	RPRM
Description		sorting nexin 3	reprimo, TP53 dependent G2 arrest mediator homolog
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Clathrin-coated Vesicle Retromer Complex Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Phagocytic Vesicle Extracellular Exosome	Cytoplasm Membrane
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-5-phosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol Phosphate Binding Retromer Complex Binding	Protein Binding
	Biological Process	Response To Bacterium Membrane Invagination Positive Regulation Of Neuron Projection Development Protein Transport Protein To Membrane Docking Regulation Of Wnt Signaling Pathway Endocytic Recycling Late Endosome To Golgi Transport Negative Regulation Of Protein Catabolic Process Host-mediated Suppression Of Symbiont Invasion Negative Regulation Of Phagocytosis Negative Regulation Of Protein Transport Intralumenal Vesicle Formation Negative Regulation Of Early Endosome To Late Endosome Transport	Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle
Pathways		WNT ligand biogenesis and trafficking Ub-specific processing proteases
Drugs		S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
GWAS			Anti-saccade response ( 29064472) Blood trace element (Zn levels) ( 23720494) Heel bone mineral density ( 30598549) Lung cancer ( 28604730) Recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		10 interacting genes: ARL6IP1 BARD1 BRCA1 LIG4 PAXIP1 RPRM SCNN1A STX11 TSC22D2 USP10	80 interacting genes: ADGRG3 AMIGO1 AQP6 ARFIP1 ASGR2 BNIP3 BSCL2 BTNL9 C16orf54 CD33 CD53 CD69 CLDN5 CLDN7 CLDN9 CLEC17A CLEC2D COQ8A CREB3 CXorf66 EHHADH EMP1 FAM209A FAM210B FATE1 FBXL19 FCGR1A FFAR2 FGD2 FKBP7 FNDC9 GAD2 GJA5 GJB3 GJB5 GNG13 GPR37L1 GPR42 GPX8 HHLA2 HIP1 HSD17B13 KCNJ6 LAPTM5 LHFPL5 LMNA LPAR6 MPP1 MS4A4A MTIF3 OPRD1 OPRM1 PBX3 PDZK1IP1 PLEKHF2 PNKP SCAND1 SDCBP SENP2 SLC18A1 SLC38A1 SMIM3 SNX11 SNX12 SNX3 SPACA1 SPCS1 STOM SUSD3 SYT16 TM4SF18 TMEM106C TMEM237 TMEM79 TMEM80 TMEM86B TSPO2 TTPA WDFY2 ZDHHC22
Entrez ID		8724	56475
HPRD ID		09333	18002
Ensembl ID		ENSG00000112335	ENSG00000177519
Uniprot IDs		O60493	Q9NS64
PDB IDs		2MXC 2YPS 5F0J 5F0L 5F0M 5F0P 7BLO
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Response To Ionizing Radiation BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex DNA Repair BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Cellular Response To Ionizing Radiation DNA Recombination DNA Strand Resection Involved In Replication Fork Processing DNA Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition DNA Damage Response Regulation Of DNA Damage Checkpoint Response To Radiation Signal Transduction In Response To DNA Damage Protein K6-linked Ubiquitination Cellular Response To Radiation Regulation Of Cell Cycle Condensed Chromosome Postreplication Repair Homologous Recombination DNA Damage Response, Signal Transduction By P53 Class Mediator Chromatin Remodeling Mitotic G2/M Transition Checkpoint Negative Regulation Of MRNA 3'-end Processing Establishment Of Integrated Proviral Latency Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle P53 Binding Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Chromatin Organization Negative Regulation Of Apoptotic Process Cellular Response To Stress Establishment Of Viral Latency Negative Regulation Of Stress Granule Assembly DNA Biosynthetic Process Negative Regulation Of Programmed Cell Death Signal Transduction By P53 Class Mediator Ubiquitin Ligase Complex Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Ligase (ATP) Activity DNA Ligase IV Complex DNA Ligase Activity Chorion Development Pro-B Cell Differentiation	Membrane Protein Binding Plasma Membrane Negative Regulation Of Early Endosome To Late Endosome Transport Connexin Complex Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Gap Junction Channel Activity Endoplasmic Reticulum Phosphatidylinositol Binding External Side Of Plasma Membrane Gap Junction Gamma-aminobutyric Acid Biosynthetic Process Phosphatidylinositol Phosphate Binding Late Endosome To Golgi Transport
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